[1]牛春生.孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大的效果[J].医学信息,2020,33(22):153-155.[doi:10.3969/j.issn.1006-1959.2020.22.044]
　NIU Chun-sheng.The Effect of Montelukast Sodium Combined with Mometasone Furoate in the Treatment of Mild to Moderate Adenoid Hypertrophy Caused by Allergic Rhinitis[J].Medical Information,2020,33(22):153-155.[doi:10.3969/j.issn.1006-1959.2020.22.044]
点击复制

孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大的效果()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年22期
页码:
153-155
栏目:
药物与临床
出版日期:
2020-11-15

文章信息/Info

Title:
The Effect of Montelukast Sodium Combined with Mometasone Furoate in the Treatment of Mild to Moderate Adenoid Hypertrophy Caused by Allergic Rhinitis
文章编号:
1006-1959（2020）22-0153-03
作者:
牛春生
（天津市宝坻区人民医院耳鼻咽喉科，天津 301800）
Author(s):
NIU Chun-sheng
(Department of Otorhinolaryngology,People’s Hospital of Baodi District,Tianjin 301800,China)
关键词:
过敏性鼻炎; 腺样体肥大; 孟鲁司特钠; 糠酸莫米松
Keywords:
Allergic rhinitis; Adenoid hypertrophy; Montelukast sodium; Momethasone furoate
分类号:
R766
DOI:
10.3969/j.issn.1006-1959.2020.22.044
文献标志码:
A
摘要:
目的 探讨孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大的临床效果，评估其对患者生活质量的影响。方法 选取2017年2月~2019年6月在本院治疗的69例过敏性鼻炎致轻中度腺样体肥大患者作为研究对象，按随机数表方法分为对照组（35例）与观察组（34例）。对照组予以糠酸莫米松治疗，观察组在此基础上加用孟鲁司特钠治疗，比较两组临床疗效、症状指标评分和A/N值、生活质量及血清因子水平（TGF-β1、IL-17）。结果 观察组总有效率为94.12%，高于对照组的74.29%，差异有统计学意义（P＜0.05）；治疗后，两组症状指标评分和A/N值均下降，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组社会、躯体、情绪、角色及认知功能评分均高于对照组，差异有统计学意义（P＜0.05）；治疗后，两组TGF-β1、IL-17水平均下降，且观察组低于对照组，差异有统计学意义（P＜0.05）。结论 孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大疗效可靠，能够改善患者临床症状，降低血清因子水平，提高生活质量，值得临床应用。
Abstract:
Objective To investigate the clinical effect of montelukast sodium combined with mometasone furoate in the treatment of mild to moderate adenoid hypertrophy caused by allergic rhinitis, and to evaluate its impact on the quality of life of patients.Methods 69 patients with mild to moderate adenoid hypertrophy caused by allergic rhinitis who were treated in our hospital from February 2017 to June 2019 were selected as the research objects, and were divided into the control group (35 cases) and the observation group according to the random number table method (34 cases). The control group was treated with mometasone furoate, and the observation group was treated with montelukast sodium on this basis. The clinical efficacy, symptom index scores and A/N values, quality of life and serum factor levels (TGF-β1, IL-17).Results The total effective rate of the observation group was 94.12%, which was higher than 74.29% of the control group,the difference was statistically significant (P<0.05); after treatment, the symptom index scores and A/N values of the two groups decreased, and the observation group was lower than the control group,the difference was statistically significant (P<0.05); the social, physical, emotional, role and cognitive function scores of the observation group were higher than those of the control group,the difference was statistically significant (P<0.05); after treatment, the two groups had TGF -β1, IL-17 levels decreased, and the observation group was lower than the control group, the difference was statistically significant (P<0.05).Conclusion Montelukast sodium combined with mometasone furoate has a reliable effect on the treatment of mild to moderate adenoid hypertrophy caused by allergic rhinitis. It can improve the clinical symptoms of patients, reduce serum factor levels, and improve the quality of life. It is worthy of clinical application.

参考文献/References:

[1]高惠萍,庞敏飞.腺样体肥大儿童合并慢性鼻窦炎的临床调查及相关性分析[J].中国耳鼻咽喉头颈外科,2015,22(2):89-91.[2]高黎,徐洁.白三烯受体拮抗药联合鼻喷激素治疗不同程度腺样体肥大合并变应性鼻炎患儿的临床观察[J].中国药房,2016,27(29):4124-4126.[3]梁昆,田克勇,岳波,等.高渗海水联合孟鲁司特钠治疗鼻-鼻窦炎所致儿童上气道咳嗽综合征的疗效[J].儿科药学杂志,2019,15(9):9-11.[4]李晓霞.儿童腺样体肥大的诊断[J].包头医学院学报,2012,28(5):67-68.[5]徐佩茹,李敏.过敏性鼻炎的诊断与治疗新进展[J].临床儿科杂志,2007,25(1):4-7.[6]石军梅,王晓翔,刘英,等.EORTC QLQ-C30量表应用于胃癌术后化疗患者的信效度检验[J].河北医科大学学报,2015,36(4):448.[7]刘炜,陈仁杰.糠酸莫米松鼻喷剂联合孟鲁司特钠治疗儿童腺样体肥大的疗效观察[J].临床耳鼻咽喉头颈外科杂志,2017,31(5):366-368,373.[8]邱立志,蒲海波,杨传楹.清腺方联合辅舒良鼻喷剂治疗儿童腺样体肥大的效果及对睡眠质量、呼吸功能的影响[J].中华中医药学刊,2019,37(7):1771-1773.[9]崔珑.通窍鼻炎片联合糠酸莫米松鼻喷雾剂对变应性鼻炎患儿的随机对照研究[J].四川中医,2016,34(6):193-195.[10]李娟,程杰,何艳.鼻腔冲洗联合糠酸莫米松鼻喷雾剂治疗变应性鼻炎的疗效观察[J].重庆医学,2016,45(25):3506-3507.[11]熊春华.小儿腺样体肥大糠酸莫米松治疗的效果观察[J].中国妇幼健康研究,2017,28(4):455-456.[12]亓玉丽,林荣军,路玲,等.孟鲁司特钠、氯雷他定联合糠酸莫米松治疗儿童过敏性鼻炎并腺样体肥大疗效观察[J].儿科药学杂志,2016,22(3):23-26.[13]刘原虎,初平,刘悄吟,等.糠酸莫米松治疗儿童腺样体肥大的Meta分析[J].标记免疫分析与临床,2014,21(3):271-275.[14]黎润球,何锦添,叶贝华.孟鲁司特钠联合糠酸莫米松对轻中度腺样体肥大患儿TGFβ1、IL17及Th17/Treg的影响[J].河北医科大学学报,2018,39(4):434-439.

相似文献/References:

[1]杨 磊.等离子射频消融术治疗腺样体肥大对术中创伤程度和术后免疫功能的影响分析[J].医学信息,2018,31(04):98.[doi:10.3969/j.issn.1006-1959.2018.04.032]
　YANG Lei.Effect of Plasma Radiofrequency Ablation on Intraoperative Trauma and Postoperative Immune Function in Patients with Adenoid Hypertrophy[J].Medical Information,2018,31(22):98.[doi:10.3969/j.issn.1006-1959.2018.04.032]
[2]王超群,柴茂山.小青龙汤加减治疗过敏性鼻炎的疗效分析[J].医学信息,2018,31(04):141.[doi:10.3969/j.issn.1006-1959.2018.04.051]
　WANG Chao-qun,CHAI Mao-shan.Therapeutic Effect of Xiao Qing Long Decoction on Allergic Rhinitis[J].Medical Information,2018,31(22):141.[doi:10.3969/j.issn.1006-1959.2018.04.051]
[3]魏 巍.地氯雷他定联合盐酸氮卓斯汀鼻喷剂治疗过敏性鼻炎疗效分析[J].医学信息,2019,32(04):145.[doi:10.3969/j.issn.1006-1959.2019.04.047]
　WEI Wei.Therapeutic Effect of Desloratadine Combined with Azelastine Hydrochloride Nasal Spray on Allergic Rhinitis[J].Medical Information,2019,32(22):145.[doi:10.3969/j.issn.1006-1959.2019.04.047]
[4]苏梦可,杨一民.nFeNO检测在儿童过敏性鼻炎中的应用[J].医学信息,2020,33(12):40.[doi:10.3969/j.issn.1006-1959.2020.12.013]
　SU Meng-ke,YANG Yi-min.Application of nFeNO Detection in Children with Allergic Rhinitis[J].Medical Information,2020,33(22):40.[doi:10.3969/j.issn.1006-1959.2020.12.013]
[5]许海英.家庭干预对过敏性鼻炎患者自我护理能力、临床症状改善的影响[J].医学信息,2021,34(12):182.[doi:10.3969/j.issn.1006-1959.2021.12.050]
　XU Hai-ying.Influence of Family Intervention on Self-care Ability and Improvement of Clinical Symptoms in Patients with Allergic Rhinitis[J].Medical Information,2021,34(22):182.[doi:10.3969/j.issn.1006-1959.2021.12.050]
[6]李元庆,付亚宁,张丽娟,等.TGF-β1、IL-5、IL-10在过敏性鼻炎中的意义[J].医学信息,2023,36(22):128.[doi:10.3969/j.issn.1006-1959.2023.22.029]
　LI Yuan-qing,FU Ya-ning,ZHANG Li-juan,et al.Significance of TGF-β1, IL-5 and IL-10 in Allergic Rhinitis[J].Medical Information,2023,36(22):128.[doi:10.3969/j.issn.1006-1959.2023.22.029]
[7]苏 涛,汤 锋,朱美红.口呼出一氧化氮水平检测在腺样体肥大患儿中的应用价值[J].医学信息,2024,37(02):143.[doi:10.3969/j.issn.1006-1959.2024.02.029]
　SU Tao,TANG Feng,ZHU Mei-hong.Application Value of Fraction of Exhaled Nitric Oxide Detection in Children with Adenoidal Hypertrophy[J].Medical Information,2024,37(22):143.[doi:10.3969/j.issn.1006-1959.2024.02.029]
[8]张 娟,陈立娟,杨华栋,等.过敏性鼻炎中医证型特点分析[J].医学信息,2024,37(03):53.[doi:10.3969/j.issn.1006-1959.2024.03.009]
　ZHANG Juan,CHEN Li-juan,YANG Hua-dong,et al.Analysis of the Characteristics of TCM Syndromes of Allergic Rhinitis[J].Medical Information,2024,37(22):53.[doi:10.3969/j.issn.1006-1959.2024.03.009]

更新日期/Last Update: 1900-01-01