[1]李元庆,付亚宁,张丽娟,等.TGF-β1、IL-5、IL-10在过敏性鼻炎中的意义[J].医学信息,2023,36(22):128-131.[doi:10.3969/j.issn.1006-1959.2023.22.029]
　LI Yuan-qing,FU Ya-ning,ZHANG Li-juan,et al.Significance of TGF-β1, IL-5 and IL-10 in Allergic Rhinitis[J].Journal of Medical Information,2023,36(22):128-131.[doi:10.3969/j.issn.1006-1959.2023.22.029]
点击复制

TGF-β1、IL-5、IL-10在过敏性鼻炎中的意义()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年22期
页码:
128-131
栏目:
论著
出版日期:
2023-11-15

文章信息/Info

Title:
Significance of TGF-β1, IL-5 and IL-10 in Allergic Rhinitis
文章编号:
1006-1959（2023）22-0128-04
作者:
李元庆; 付亚宁; 张丽娟; 等
（1.昌邑市人民医院耳鼻喉科，山东 昌邑 261300；2.昌邑市人民医院口腔修复科，山东 昌邑 261300；3.昌邑市人民医院查体中心，山东 昌邑 261300；4.陆军第八十集团军医院神经内科，山东 潍坊 261041）
Author(s):
LI Yuan-qing; FU Ya-ning; ZHANG Li-juan; et al.
(1.Department of Otorhinolaryngology,Changyi People’s Hospital,Changyi 261300,Shandong,China;2.Department of Prosthodontics,Changyi People’s Hospital,Changyi 261300,Shandong,China;3.Department of Regular Physical Examination Centre,Changyi People’s Hospital,Changyi 261300,Shandong,China; 4.Department of Internal Medicine-Neurology,Eightieth Group Army Hospital of PLA,Weifang 261041,Shandong,China)
关键词:
过敏性鼻炎; TGF-β1; IL-5; IL-10
Keywords:
Allergic rhinitis; TGF-β1; IL-5; IL-10
分类号:
R765
DOI:
10.3969/j.issn.1006-1959.2023.22.029
文献标志码:
A
摘要:
目的 观察过敏性鼻炎患者血清中TGF-β1、IL-5和IL-10的表达水平，并探讨在过敏性鼻炎中的作用。方法 选取2019年1月-2022年4月在昌邑市人民医院就诊的30例过敏性鼻炎患者作为观察组，并选取30例同期正常健康查体人群作为对照组，比较两组血清TGF-β1、IL-5、IL-10水平，探讨观察组TGF-β1、IL-5、IL-10与病情持续时间、是否有睡眠障碍及是否伴打鼾的关系以及TGF-β1与IL-5、IL-10的相关性。结果 观察组血清TGF-β1、IL-5、IL-10表达水平高于对照组（P＜0.05）；观察组血清TGF-β1、IL-5、IL-10与病情持续时间、是否有睡眠障碍及是否伴打鼾均无关（P＞0.05）；TGF-β1与IL-5（r=0.349，P=0.029）、IL-10（r=0.388，P=0.017）均呈正相关。结论 过敏性鼻炎患者血清中TGF-β1、IL-5、IL-10的表达高于健康人群，且其TGF-β1的表达与IL-5、IL-10的表达呈正相关。TGF-β1、IL-5、IL-10参与了过敏性鼻炎的发生发展。
Abstract:
Objective To observe the expression levels of serum TGF-β1, IL-5 and IL-10 of patients with allergic rhinitis, and to explore the role of TGF-β1, IL-5 and IL-10 in allergic rhinitis.Methods Thirty patients with allergic rhinitis who were treated in Changyi People’s Hospital from January 2019 to April 2022 were selected as the observation group, and 30 normal healthy people in the same period were selected as the control group. The levels of serum TGF-β1, IL-5 and IL-10 were compared between the two groups. The relationship between TGF-β1, IL-5, IL-10 and the duration of the disease, whether there is sleep disorder and whether there was snoring, and the correlation between TGF-β1 and IL-5, IL-10 in the observation group were discussed.Results The expression levels of serum TGF-β1, IL-5 and IL-10 in the observation group were higher than those in the control group (P<0.05). The serum levels of TGF-β1, IL-5 and IL-10 in the observation group were not related to the duration of the disease, whether there was sleep disorder and whether there was snoring (P>0.05). TGF-β1 was positively correlated with IL-5 (r=0.349, P=0.029) and IL-10 (r=0.388, P=0.017).Conclusion The expression of serum TGF-β1, IL-5 and IL-10 of patients with allergic rhinitis is higher than that of healthy people, and the expression of TGF-β1 is positively correlated with the expression of IL-5 and IL-10. TGF-β1, IL-5 and IL-10 are involved in the occurrence and development of allergic rhinitis.

参考文献/References:

[1]李满群,许清河.儿童过敏性鼻炎患儿外周血Th1/Th2表达及临床意义[J].中国妇幼保健,2022,37(3):473-475. [2]梁希仁,张天蕊.氯雷他定与布地奈德鼻喷剂对过敏性鼻炎的应用及IL-6,IL-8水平影响分析[J].中国医学文摘(耳鼻咽喉科学),2021,36(6):148-151. [3]朱开彬,贺长军,陈澜涛,等.TAM通过PLGF/Flt-1和TGF-β1通路促进非小细胞肺癌生长和肿瘤血管异生的研究[J].实用肿瘤学杂志,2022,36(5):391-397.[4]张超,李永帅,章晓联,等.屋尘螨过敏原对人支气管上皮细胞IL-32和相关炎症因子的影响[J].中华临床免疫和变态反应杂志,2021,15(3):257-263. [5]朱久龙,谢青,黄雅珍,等.鳖甲-莪术药对对TGF-β1诱导的MDA-MB-231细胞侵袭转移能力及其上皮间质转化的作用及机制[J].贵州医科大学学报,2022,47(11):1264-1273. [6]Wang YX,Gu ZW,Cao ZW.Difference between CD25+Tregs and Helios+Tregs in a murine model of allergic rhinitis[J].Braz J Otorhinolaryngol,2021,87(5):550-556. [7]祖木热提古丽·阿不来提,陈镭雨,马琰迪,等.TRPV4和TGF-β1在口腔鳞状细胞癌中的表达及临床意义[J].实用口腔医学杂志,2022,38(6):743-747.[8]Chong DLW,Trinder S,Labelle M,et al.Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing[J].J Tissue Eng Regen Med,2020,14(4):645-649.[9]Zhang M,Wang H,Wang X,et al.MG53/CAV1 regulates transforming growth factor-β1 signaling-induced atrial fibrosis in atrial fibrillation[J].Cell Cycle,2020,19(20):2734-2744.[10]高刘炯,李小磊,宁文慧,等.脓毒症合并急性肺损伤患儿Th1/Th2比值及细胞因子临床意义分析[J].检验医学与临床,2022,19(21):2922-2925. [11]刘晓莉,王克芳.围绝经期抑郁症患者血清Th1/Th2型细胞因子水平的变化及其意义[J].现代免疫学,2022,42(6):505-510. [12]范慧,索涛,苏梦茹,等.感染源性急性呼吸窘迫综合征患者血Th1和Th2细胞及相关细胞因子检测的临床意义[J].临床肺科杂志,2021,26(8):1189-1192,1197.[13]黄莹,郑秀琴,陈岚.特步他林并布地奈德治疗对急性支气管哮喘患者IL-5、IL-10及TNF-α的影响[J].分子诊断与治疗杂志,2022,14(1):161-164.[14]韩佳琦.慢性鼻窦炎伴鼻息肉患者血清25-（OH）D3水平与组织中TGF-β1的表达及相关性研究[D].沈阳:中国医科大学,2021.[15]闫京京,张京荣,于乔,等.过敏性紫癜患儿肠道菌群B/E值变化与血清Gd-IgA1、TGF-β1及IGF-1的相关性分析[J].徐州医科大学学报,2021,41(11):823-826. [16]苏航.血清VEGF、TGF-β1水平与支气管哮喘患儿丙酸氟替卡松治疗疗效的关系[J].江西医药,2021,56(9):1456-1458,1472.[17]田亮,张伟.白三烯受体拮抗剂对过敏性鼻炎模型大鼠血清IL-6、IL-10及TNF-α表达的影响[J].河北医药,2019,41(19):2889-2893. [18]李颖,李玉杰,于敏,等.IL-10基因多态性与过敏性鼻炎遗传易感性的相关性研究[J].热带医学杂志,2021,21(10):1290-1293.[19]何玮,胡敏,梁兴明,等.外周血辅助性T细胞9细胞因子与过敏性鼻炎患者疾病严重程度的相关性[J].广西医学,2021,43(14):1691-1694. [20]Zhou F,Liu P,Lv H,et al.miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses[J].Mol Med Rep,2021,23(1):42.

相似文献/References:

[1]王超群,柴茂山.小青龙汤加减治疗过敏性鼻炎的疗效分析[J].医学信息,2018,31(04):141.[doi:10.3969/j.issn.1006-1959.2018.04.051]
　WANG Chao-qun,CHAI Mao-shan.Therapeutic Effect of Xiao Qing Long Decoction on Allergic Rhinitis[J].Journal of Medical Information,2018,31(22):141.[doi:10.3969/j.issn.1006-1959.2018.04.051]
[2]黄 花,徐冬冬,章丽霞.TGF-β1在宫颈癌中的研究进展[J].医学信息,2018,31(12):31.[doi:10.3969/j.issn.1006-1959.2018.12.011]
　HUANG Hua,XU Dong-dong,ZHANG Li-xia.Research Progress of TGF-β1 in Cervical Cancer[J].Journal of Medical Information,2018,31(22):31.[doi:10.3969/j.issn.1006-1959.2018.12.011]
[3]李 莹,杨 宇,王 迪,等.Ang-2对肝再生作用机制的研究进展[J].医学信息,2019,32(03):31.[doi:10.3969/j.issn.1006-1959.2019.03.011]
　LI Ying,YANG Yu,WANG Di,et al.Progress in Research on the Mechanism of Ang-2 on Liver Regeneration[J].Journal of Medical Information,2019,32(22):31.[doi:10.3969/j.issn.1006-1959.2019.03.011]
[4]魏 巍.地氯雷他定联合盐酸氮卓斯汀鼻喷剂治疗过敏性鼻炎疗效分析[J].医学信息,2019,32(04):145.[doi:10.3969/j.issn.1006-1959.2019.04.047]
　WEI Wei.Therapeutic Effect of Desloratadine Combined with Azelastine Hydrochloride Nasal Spray on Allergic Rhinitis[J].Journal of Medical Information,2019,32(22):145.[doi:10.3969/j.issn.1006-1959.2019.04.047]
[5]韩玉丽,刘琪琪,李 真,等.增生性瘢痕分子信号通路研究[J].医学信息,2019,32(22):31.[doi:10.3969/j.issn.1006-1959.2019.22.011]
　HAN Yu-li,LIU Qi-qi,LI Zhen,et al.Study on Molecular Signaling Pathway of Hypertrophic Scar[J].Journal of Medical Information,2019,32(22):31.[doi:10.3969/j.issn.1006-1959.2019.22.011]
[6]苏梦可,杨一民.nFeNO检测在儿童过敏性鼻炎中的应用[J].医学信息,2020,33(12):40.[doi:10.3969/j.issn.1006-1959.2020.12.013]
　SU Meng-ke,YANG Yi-min.Application of nFeNO Detection in Children with Allergic Rhinitis[J].Journal of Medical Information,2020,33(22):40.[doi:10.3969/j.issn.1006-1959.2020.12.013]
[7]牛春生.孟鲁司特钠联合糠酸莫米松治疗过敏性鼻炎致轻中度腺样体肥大的效果[J].医学信息,2020,33(22):153.[doi:10.3969/j.issn.1006-1959.2020.22.044]
　NIU Chun-sheng.The Effect of Montelukast Sodium Combined with Mometasone Furoate in the Treatment of Mild to Moderate Adenoid Hypertrophy Caused by Allergic Rhinitis[J].Journal of Medical Information,2020,33(22):153.[doi:10.3969/j.issn.1006-1959.2020.22.044]
[8]许海英.家庭干预对过敏性鼻炎患者自我护理能力、临床症状改善的影响[J].医学信息,2021,34(12):182.[doi:10.3969/j.issn.1006-1959.2021.12.050]
　XU Hai-ying.Influence of Family Intervention on Self-care Ability and Improvement of Clinical Symptoms in Patients with Allergic Rhinitis[J].Journal of Medical Information,2021,34(22):182.[doi:10.3969/j.issn.1006-1959.2021.12.050]
[9]金力荣,杨麦青,徐洪波,等.TGF-β1、HIF-1α在输卵管妊娠中的表达和意义[J].医学信息,2022,35(08):85.[doi:10.3969/j.issn.1006-1959.2022.08.020]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.The Expression and Significance of TGF-β1, HIF-1α in Tubal Pregnancy[J].Journal of Medical Information,2022,35(22):85.[doi:10.3969/j.issn.1006-1959.2022.08.020]
[10]金力荣,杨麦青,徐洪波,等.TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义[J].医学信息,2022,35(11):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest[J].Journal of Medical Information,2022,35(22):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]

更新日期/Last Update: 1900-01-01