[1]袁 瑞,余亚莉.吡格列酮二甲双胍片治疗胰岛素抵抗型多囊卵巢综合征患者的疗效[J].医学信息,2021,34(01):158-160.[doi:10.3969/j.issn.1006-1959.2021.01.043]
　YUAN Rui,YU Ya-li.Efficacy of Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets in the Treatment of Patients with Insulin-resistant Polycystic Ovary Syndrome[J].Medical Information,2021,34(01):158-160.[doi:10.3969/j.issn.1006-1959.2021.01.043]
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吡格列酮二甲双胍片治疗胰岛素抵抗型多囊卵巢综合征患者的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年01期
页码:
158-160
栏目:
药物与临床
出版日期:
2021-01-01

文章信息/Info

Title:
Efficacy of Pioglitazone Hydrochloride and Metformin Hydrochloride Tablets in the Treatment of Patients with Insulin-resistant Polycystic Ovary Syndrome
文章编号:
1006-1959（2021）01-0158-03
作者:
袁 瑞; 余亚莉
（1.西安医学院，陕西 西安 710021； 2.西北妇女儿童医院妇四科，陕西 西安 710054)
Author(s):
YUAN Rui; YU Ya-li
(1.Xi’an Medical University,Xi’an 710021,Shaanxi,China; 2.Subject Four,Department of Gynecology,Northwest Women and Children’s Hospital,Xi’an 710054,Shaanxi,China)
关键词:
多囊卵巢综合征; 胰岛素抵抗; 吡格列酮二甲双胍片
Keywords:
Polycystic ovary syndrome; Insulin resistance; Pioglitazone Hydrochloride and Metformin Hydrochloride tablets
分类号:
R711.75
DOI:
10.3969/j.issn.1006-1959.2021.01.043
文献标志码:
A
摘要:
目的 探究吡格列酮二甲双胍片治疗胰岛素抵抗（IR）型多囊卵巢综合征（PCOS）患者的临床疗效。方法 选取2018年6月~2019年12月在西北妇女儿童医院收治的50例IR型PCOS患者作为研究对象，予以同等剂量的吡格列酮二甲双胍片治疗12周后，比较治疗前后性激素水平、血糖、血脂、胰岛素抵抗指数、体重指数、甲状腺功能及肝肾功能指标变化情况。结果 治疗后患者LH、PRL、T低于治疗前，差异有统计学意义（P＜0.05）；而治疗前后患者FSH、E2、P比较，差异无统计学意义（P＞0.05）。治疗后患者FPG、FINS、PBG、PINS、TC、LDL-C及HOMA-IR低于治疗前，HDL-C高于治疗前，差异有统计学意义（P＜0.05）；而治疗前后患者TG比较，差异无统计学意义（P＞0.05）。治疗后患者TSH、ALT、AST、SCr、BUN及BMI低于治疗前，差异有统计学意义（P＜0.05）。结论 吡格列酮二甲双胍片能改善IR型PCOS患者的胰岛素抵抗，增加胰岛素的敏感性，调节患者体内性激素水平，纠正糖脂代谢紊乱，同时也能改善患者的甲状腺功能，并且对患者的肝肾功能无明显影响。
Abstract:
Objective To explore the clinical efficacy of Pioglitazone Hydrochloride and Metformin Hydrochloride tablets in the treatment of patients with insulin resistance(IR) type polycystic ovary syndrome(PCOS) and basis for the treatment of IR type PCOS patients.Methods 50 patients with IR type PCOS treated in gynecological endocrine clinic from June 2018 to December 2019 in Northwest Women and Children’s Hospital are selected as the research subjects. After 12 weeks of treatment with the same dose of Pioglitazone Hydrochloride and Metformin Hydrochloride tablets, we observe the changes of sex hormone level, blood glucose, blood lipid, insulin resistance index, body mass index, thyroid function and liver and kidney function index before and after treatment.Results After treatment, the LH, PRL, and T of the patients were lower than before treatment, the difference was statistically significant (P<0.05); while the comparison of FSH, E2, P before and after treatment, the difference was not statistically significant (P>0.05). After treatment, the FPG, FINS, PBG, PINS, TC, LDL-C and HOMA-IR of the patients were lower than before treatment, and HDL-C was higher than before treatment, the difference was statistically significant (P＜0.05); and the comparison of TG before and after treatment,the difference was not statistically significant (P>0.05). The TSH, ALT, AST, SCr, BUN and BMI of the patients after treatment were lower than those before treatment,the difference was statistically significant (P<0.05).Conclusion Pioglitazone Hydrochloride and Metformin Hydrochloride tablets can improve insulin resistance, increase insulin sensitivity, regulate the level of sex hormones in patients，correct the disorder of glycolipid metabolism with IR type PCOS, but also improve the thyroid function of patients, and have no obvious effect on the liver and kidney function of patients.

参考文献/References:

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更新日期/Last Update: 1900-01-01