[1]甄秀丽,冯国鹏.房颤合并冠心病患者冠脉支架植入术后二联和三联抗凝治疗的效果比较[J].医学信息,2021,34(03):162-164.[doi:10.3969/j.issn.1006-1959.2021.03.046]
　ZHEN Xiu-li,FENG Guo-peng.Comparison of the Effects of Dual and Triple Anticoagulation Therapy in Patients with Atrial Fibrillation and Coronary Heart Disease After Coronary Stent Implantation[J].Medical Information,2021,34(03):162-164.[doi:10.3969/j.issn.1006-1959.2021.03.046]
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房颤合并冠心病患者冠脉支架植入术后二联和三联抗凝治疗的效果比较()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年03期
页码:
162-164
栏目:
药物与临床
出版日期:
2021-02-01

文章信息/Info

Title:
Comparison of the Effects of Dual and Triple Anticoagulation Therapy in Patients with Atrial Fibrillation and Coronary Heart Disease After Coronary Stent Implantation
文章编号:
1006-1959（2021）03-0162-03
作者:
甄秀丽; 冯国鹏
（武清区人民医院心血管内科，天津 301700）
Author(s):
ZHEN Xiu-li; FENG Guo-peng
(Department of Cardiovascular Medicine,People’s Hospital of Wuqing District,Tianjin 301700,China)
关键词:
房颤; 冠心病; 冠脉支架植入术; 三联抗凝
Keywords:
Atrial fibrillation; Coronary heart disease; Coronary stent implantation; Triple anticoagulation
分类号:
R541.7
DOI:
10.3969/j.issn.1006-1959.2021.03.046
文献标志码:
A
摘要:
目的 比较房颤合并冠心病患者冠脉支架植入术后二联和三联抗凝治疗效果。方法 选取2019年10月~2020年10月在我院行冠脉支架植入术的106例房颤合并冠心病患者为研究对象，采用随机数字表法分为对照组和观察组，各53例。对照组术后采用二联抗凝治疗，观察组采用三联抗凝治疗，比较两组再狭窄发生率、炎症指标、凝血功能指标、出血事件发生率、心血管不良事件发生情况。结果 观察组再狭窄率为1.88%，低于对照组的7.54%，差异有统计学意义（P＜0.05）；治疗后两组 hs-CRP、IL-6、PLT、Fg、D-D均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组出血事件发生率为7.54%、血管不良事件发生率为3.77%、缺血性卒中发生率为3.77%，均低于对照组的9.43%、11.32%、9.43%，差异有统计学意（P＜0.05）。结论 房颤合并冠心病患者冠脉支架植入术后三联抗凝效果更优，可降低再狭窄率，促进炎症吸收，改善凝血功能指标，预防心血管不良事件的发生，降低缺血性卒中发生率，且不会增加出血发生率，临床应用安全可靠。
Abstract:
Objective To compare the effects of dual and triple anticoagulation therapy in patients with atrial fibrillation and coronary heart disease after coronary stent implantation.Methods A total of 106 patients with atrial fibrillation and coronary heart disease who underwent coronary stent implantation in our hospital from October 2019 to October 2020 were selected as the research objects. They were divided into control group and observation group by random number table, with 53 cases in each group.The control group was treated with dual anticoagulation therapy after operation, and the observation group was treated with triple anticoagulation therapy. The incidence of restenosis, inflammatory indexes, coagulation function indexes, bleeding events, and adverse cardiovascular events were compared between the two groups.Results The restenosis rate in the observation group was 1.88%, which was lower than 7.54% in the control group,the difference was statistically significant (P＜0.05);After treatment, hs-CRP, IL-6, PLT, Fg, D-D in the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P＜0.05);The incidence of bleeding events in the observation group was 7.54%, the incidence of vascular adverse events was 3.77%, and the incidence of ischemic stroke was 3.77%, which were all lower than those in the control group of 9.43%, 11.32%, and 9.43%,the difference was statistically significant(P＜0.05).Conclusion The triple anticoagulation effect of patients with atrial fibrillation and coronary heart disease after coronary stent implantation is better, which can reduce the rate of restenosis, promote inflammation absorption, improve coagulation function indexes, prevent the occurrence of adverse cardiovascular events, and reduce the occurrence of ischemic stroke without increasing the incidence of bleeding, the clinical application is safe and reliable.

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更新日期/Last Update: 1900-01-01