[1]李丹丹,刘 伟,张万红,等.局部降眼压药物对青光眼患者后视盘及其周围血流密度变化的影响[J].医学信息,2021,34(04):126-129.[doi:10.3969/j.issn.1006-1959.2021.04.033]
　LI Dan-dan,LIU Wei,ZHANG Wan-hong,et al.Effects of Local Intraocular Pressure-lowering Drugs on the Changes of Posterior Optic Disc and Surrounding Blood Flow Density in Patients with Glaucoma[J].Medical Information,2021,34(04):126-129.[doi:10.3969/j.issn.1006-1959.2021.04.033]
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局部降眼压药物对青光眼患者后视盘及其周围血流密度变化的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
126-129
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
Effects of Local Intraocular Pressure-lowering Drugs on the Changes of Posterior Optic Disc and Surrounding Blood Flow Density in Patients with Glaucoma
文章编号:
1006-1959（2021）04-0126-04
作者:
李丹丹; 刘 伟; 张万红; 等
（1.天津市泰达医院/天津医科大学眼科医院泰达眼科中心青光眼科，天津 300457； 2.天津医科大学眼科医院眼视光学院/天津医科大学眼科研究所青光眼科，天津 300384）
Author(s):
LI Dan-dan; LIU Wei; ZHANG Wan-hong; et al.
(1.Tianjin TEDA Hospital/Department of Glaucoma,TEDA Eye Center,Tianjin Medical University Eye Hospital,Tianjin 300457,China; 2.School of Optometry,Tianjin Medical University Eye Hospital/Glaucoma Department,Institute of Ophthalmology,Tianjin Medical Univ
关键词:
青光眼; 光学相干断层扫描血管成像; 降眼压药物; 视盘整体血流密度; 盘周血流密度
Keywords:
Glaucoma; Optical coherence tomography angiography; Intraocular pressure lowering drugs;  Whole optic disc blood flow density; Peridiscal blood flow density
分类号:
R775
DOI:
10.3969/j.issn.1006-1959.2021.04.033
文献标志码:
A
摘要:
目的 观察青光眼患者局部应用降眼压药物后视盘血流密度的变化。方法 选择2019年2月~9月我院门诊收治的原发性青光眼患者32例（48眼）作为研究对象，局部应用2%盐酸卡替洛尔滴眼液、布林佐胺滴眼液和酒石酸溴莫尼定滴眼液治疗，比较患者治疗前、用药1周、1个月时眼压、视网膜神经纤维层厚度（RNFL）、视网膜神经节细胞复合体（GCC）厚度、C/D 值、视盘整体血流密度及盘周血流密度，分析影响视盘血流密度的相关因素。结果 用药1周、1个月，患者眼压分别为（15.98±2.70）mmHg和（16.47±4.15）mmHg，均低于用药前的（31.65±5.35）mmHg，差异有统计学意义（P＜0.05）；用药前，视盘整体及盘周血流密度分别为（49.64±4.87）%和（37.72±3.25）%，用药1周视盘整体及盘周血流密度为（52.14±5.30）%和（39.91±3.33）%，1个月后为（52.13±5.13）%和（40.03±3.37）%，均较用药前增加，差异有统计学意义（P＜0.05）；用药1周、1个月C/D 值、RNFL厚度、GCC厚度与用药前比较，差异无统计学意义（P＞0.05）；视盘整体血流密度和盘周血流密度的增加量与眼压下降量、C/D值、RNFL厚度、GCC厚度的变化量无相关性（P＞0.05）。结论 青光眼患者局部应用降眼压药物后眼压改善效果较好，视盘整体血流密度及盘周血流密度均增加，视盘血流状态得到改善。
Abstract:
Objective To observe the changes of optic disc blood flow density after local application of intraocular pressure lowering drugs in glaucoma patients.Methods 32 cases (48 eyes) of primary glaucoma patients admitted to our hospital from February to September 2019 were selected as the research objects.Topical application of 2% carteolol hydrochloride eye drops, brinzolamide eye drops and brimonidine tartrate eye drops for treatment,compare patients’ intraocular pressure, retinal nerve fiber layer thickness (RNFL), retinal ganglion cell complex (GCC) thickness, C/D value,the overall optic disc blood flow density and peridiscal blood flow density were analyzed, and the related factors affecting optic disc blood flow density were analyzed.Results The intraocular pressures of the patients were (15.98 ± 2.70) mmHg and (16.47 ± 4.15) mmHg respectively after 1 week and 1 month of medication, which were lower than the (31.65 ± 5.35) mmHg before medication,the difference was statistically significant (P<0.05);Before medication, the blood flow density of the entire optic disc and peridiscal was (49.64±4.87)% and (37.72±3.25)%, respectively.The blood flow density of the entire optic disc and peridiscal was (52.14±5.30)% and (39.91±3.33)% during the first week of medication.One month later, it was (52.13±5.13)% and (40.03±3.37)%, both of which increased compared with before medication,the difference was statistically significant (P<0.05);The C/D value, RNFL thickness and GCC thickness of 1 week and 1 month after medication were compared with those before medication,there was no significant difference (P>0.05);There was no correlation between the increase in the overall optic disc blood flow density and the peridiscal blood flow density and the decrease in intraocular pressure, C/D value, RNFL thickness, and GCC thickness (P>0.05).Conclusion After local application of intraocular pressure lowering drugs in glaucoma patients, the effect of improving intraocular pressure is better. The blood flow density of the whole optic disc and the blood flow density of the disc are increased, and the blood flow status of the optic disc is improved.

参考文献/References:

[1]Lommatzsch C,Rothaus K,Koch JM,et al.Vessel density in glaucoma of different entities as measured with optical coherence tomography angiography[J].Clin Ophthalmol,2019(13):2527-2534. [2]Zhu X,Zeng W,Wu S,et al.Measurement of retinal changes in primary acute angle closure glaucoma under different durations of symptoms[J].J Ophthalmol,2019(2019):5409837. [3]Moghimi S,Zangwill LM,Penteado RC,et al.Macular and Optic Nerve Head Vessel Density and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma[J].Ophthalmology,2018,125(11):1720-1728. [4]Tao SY,Cao GF.Evaluation of the changes in flow density at optic nerve head and peripapillary area after trabeculectomy in glaucoma patients[J].Rec Adv Ophthalmol,2019(5):437-443. [5]Werner AC,Shen LQ.A Review of OCT angiography in glaucoma[J].SeminOphthalmol,2019,34(4):279-286. [6]Jia Y,Morrison JC,Tokayer J,et al.Quantitative OCT angiography of optic nerve head blood flow[J].Biomedical Optics Express,2012,3(12):3127-3137. [7]Verticchio AC,Harris A,Tanga L,et al.Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography[J].Graefes Arch Clin Exp Ophthalmol,2020. [8]中华医学会眼科学分会青光眼组.我国原发性青光眼诊断和治疗专家共（2014）[J].中华眼科杂志,2014(5):382-382. [9]Jeon SJ,Shin DY,Park HL,et al.Association of Retinal Blood Flow with Progression of Visual Field in Glaucoma[J].Sci Rep,2019,9(1):16813. [10]Chansa S,Lin SC.Optical coherence tomography angiography in glaucoma care[J].Curr Eye Res,2018,43(9):1067-1082. [11]Zhong Y,Che HX.Detective values of optical coherence tomography angiography for primary glaucoma[J].Rec Adv Ophthalmol,2018,38(4):352-356． [12]Moghini S,Zangwill M,Penteado RC,et al.Macular and optic nerve head vessel density and progressive retinal nerve fiber layer loss in glaucoma[J].Ophthalmology,2018,125(11):1720-1728. [13]Yarmohammadi A,Zangwill LM,Diniz-Filho A,et al.Relationship between optical coherence tomography angiography vessel density and severity of visual field loss in glaucoma[J].Ophthalmology,2016,123(12):2498-2508． [14]Lommatzsch C,Rothaus K,Koch JM,et al.Vessel density in OCT angiography permits differentiation between normal and glaucomatous optic nerve heads[J].Int J Ophthalmol,2018,11(5):835-843. [15]Yu DY,Cringle SJ,Balaratnasingam C,et al.Retinal ganglion cells:energetics,compartmentation,axonal transport,cytoskeletons and vulnerability[J].Prog Retin Eye Res,2013(36):217-246. [16]Xu H,Kong XM.Study of retinal microvascular perfusion alteration and structural damage at macular region in primary open-angle glaucoma patients[J].Chin J Ophthalmol,2017,53(2):98-103. [17]Holt DG,Young J,Stagg B,et al.Anterior chamber intraocular lens,sutured posterior chamber intraocular lens,or glued intraocular lens:where do we stand[J].Curr Opin Ophthalmol,2012,23(1):62-67. [18]Umit UI,Sitki SE,Aylin Y,et al.The effects of latanoprost and brimonidine on blood flow velocity of the retrobulbar vessels:a 3-month clinical trial[J].Acta Ophthalmologica Scandinavica,2003,81(2):155-160. [19]Liu XH,Zhong YS.Effect of drugs on ocular blood vascular system in glaucoma[J].Rec Adv Ophthalmol,2006(1):67-70. [20] Reber F,Gersch U,Funk RW.Blockers of carbonic anhydrase can cause increase of retinal capillary diameter,decrease of extra-cellular and increase of intracellular pH in rat retinal organ culture[J].Graefes Arch Clin Exp Ophthalmol,2003,241(2):140-148.

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更新日期/Last Update: 1900-01-01