[1]韦春英,莫颖敏.阿尔茨海默病早期诊断的脑脊液和血液生物标志物研究[J].医学信息,2021,34(14):25-27.[doi:10.3969/j.issn.1006-1959.2021.14.007]
 WEI Chun-ying,MO Ying-min.Study on Cerebrospinal Fluid and Blood Biomarkers for Early Diagnosis of Alzheimer’s Disease[J].Medical Information,2021,34(14):25-27.[doi:10.3969/j.issn.1006-1959.2021.14.007]
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阿尔茨海默病早期诊断的脑脊液和血液生物标志物研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
25-27
栏目:
综述
出版日期:
2021-07-15

文章信息/Info

Title:
Study on Cerebrospinal Fluid and Blood Biomarkers for Early Diagnosis of Alzheimer’s Disease
文章编号:
1006-1959(2021)14-0025-03
作者:
韦春英莫颖敏
(广西壮族自治区人民医院老年神经内科,广西 南宁 530021)
Author(s):
WEI Chun-yingMO Ying-min
(Department of Geriatric Neurology,the People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,Guangxi,China)
关键词:
阿尔茨海默病脑脊液tau蛋白脑脊液神经颗粒蛋白视锥蛋白1
Keywords:
Alzheimer’s diseaseCerebrospinal fluidtau proteinCerebrospinal fluid neurograninTrypsin 1
分类号:
R742
DOI:
10.3969/j.issn.1006-1959.2021.14.007
文献标志码:
A
摘要:
阿尔茨海默病是老年期最常见的痴呆,发病率逐年增加,但其致病机制复杂,缺乏特异性治疗措施,因此早期诊断对于改善预后具有重要意义。目前,基于脑脊液及血液的生物标志物检测已经成为阿尔茨海默病早期诊断及治疗的重点之一。本文就阿尔茨海默病脑脊液及血液中的生物标志物Aβ相关的生物标志物、tau蛋白、脑脊液神经颗粒蛋白、血神经丝蛋白轻链、视锥蛋白1、炎症反应因子TREM2作一综述,以期为该病的临床早期诊断提供参考。
Abstract:
Alzheimer’s disease is the most common dementia in the elderly, and its incidence is increasing year by year. However, its pathogenic mechanism is complex and lacks specific treatment measures. Therefore, early diagnosis is of great significance for improving the prognosis.At present, the detection of biomarkers based on cerebrospinal fluid and blood has become one of the focuses of early diagnosis and treatment of Alzheimer’s disease.This article reviews the biomarkers related to Alzheimer’s disease cerebrospinal fluid and blood biomarkers Aβ, tau protein, cerebrospinal fluid neurogranin, blood neurofilament light chain, trypsin 1, inflammatory response factor TREM2.It hopes to provide a reference for the early clinical diagnosis of the disease.

参考文献/References:

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更新日期/Last Update: 1900-01-01