[1]马 磊,张民旺.解郁丸联合草酸艾司西酞普兰治疗卒中后抑郁的临床观察[J].医学信息,2021,34(17):163-165.[doi:10.3969/j.issn.1006-1959.2021.17.044]
　MA Lei,ZHANG Min-wang.Clinical Observation of Jieyu Pills Combined with Escitalopram Oxalate in the Treatment of Post-stroke Depression[J].Medical Information,2021,34(17):163-165.[doi:10.3969/j.issn.1006-1959.2021.17.044]
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解郁丸联合草酸艾司西酞普兰治疗卒中后抑郁的临床观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年17期
页码:
163-165
栏目:
中医中药
出版日期:
2021-09-01

文章信息/Info

Title:
Clinical Observation of Jieyu Pills Combined with Escitalopram Oxalate in the Treatment of Post-stroke Depression
文章编号:
1006-1959（2021）17-0163-03
作者:
马 磊; 张民旺
（1.河南推拿职业学院中医系，河南 洛阳 471023； 2.郑州市中医院脑病二科，河南 郑州 450007）
Author(s):
MA Lei; ZHANG Min-wang
(1.Department of Traditional Chinese Medicine,Henan Vocational College of Tuina,Luoyang 471023,Henan,China; 2.The Second Department of Brain Disease,Zhengzhou TCM Hospital,Zhengzhou 450007,Henan,China)
关键词:
解郁丸; 卒中后抑郁; 生活能力; 5-羟色胺; 去甲肾上腺素; 脑源性神经营养因子
Keywords:
Jieyu pills; Post-stroke depression; Living ability; 5-hydroxytryptamine; Norepinephrine; Brain-derived neurotrophic factor
分类号:
R794.1+3
DOI:
10.3969/j.issn.1006-1959.2021.17.044
文献标志码:
A
摘要:
目的 探讨解郁丸联合草酸艾司西酞普兰治疗卒中后抑郁的临床疗效。方法 选取2019年1月-2020年6月在郑州市中医院治疗的80例卒中后抑郁患者，随机分为治疗组（40例）与对照组（40例）。两组均予基础治疗，对照组口服草酸艾司西酞普兰，治疗组在对照组基础上加服解郁丸，比较两组治疗前后汉密尔顿抑郁量表（HAMD）、美国国立卫生研究院卒中量表（NIHSS）、日常生活能力量表（ADL）评分, 血清5-羟色胺（5-HT）、去甲肾上腺素（NE）、脑源性神经营养因子（BDNF）水平。结果 治疗组总有效率为92.50%，高于对照组的77.50%，差异有统计学意义（P＜0.05）；两组HAMD-24、NIHSS评分较治疗前降低，ADL评分较治疗前升高，且治疗组HAMD-24、NIHSS、ADL评分改善情况优于对照组，差异有统计学意义（P＜0.05）；两组血清5-HT、NE、BDNF水平均较治疗前升高，且治疗组改善情况优于对照组，差异有统计学意义（P＜0.05）。结论 解郁丸联合草酸艾司西酞普兰治疗卒中后抑郁临床疗效确切，能够降低抑郁程度，促进神经功恢复，改善日常生活能力，调节神经递质水平。
Abstract:
Objective To explore the clinical efficacy of Jieyu Pills combined with escitalopram oxalate in the treatment of post-stroke depression. Methods A total of 80 patients with post-stroke depression who were treated in Zhengzhou Hospital of Traditional Chinese Medicine from January 2019 to June 2020 were selected and randomly divided into treatment group (40 cases) and control group (40 cases).Both groups were given basic treatment. The control group was given oral escitalopram oxalate, and the treatment group was given Jieyu pills on the basis of the control group.Compare the Hamilton Depression Scale (HAMD), the National Institutes of Health Stroke Scale (NIHSS), the ability of daily living (ADL) scores, serum serotonin (5-HT), and norepinephrine (NE), brain-derived neurotrophic factor (BDNF) levels.Results The total effective rate in the treatment group was 92.50%, which was higher than 77.50% in the control group,the difference was statistically significant(P＜0.05);The HAMD-24 and NIHSS scores of the two groups were lower than before treatment, and the ADL score was higher than before treatment. The improvement of HAMD-24, NIHSS and ADL scores of the treatment group was better than that of the control group,the difference was statistically significant(P＜0.05);The levels of serum 5-HT, NE and BDNF in the two groups were higher than before treatment, and the improvement of the treatment group was better than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Jieyu pill combined with escitalopram oxalate has a definite clinical effect in the treatment of post-stroke depression, which can reduce the degree of depression, promote the recovery of nerve function, improve the ability of daily living, and regulate the level of neurotransmitters.

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更新日期/Last Update: 1900-01-01