[1]何田田,施会敏,甘卫华,等.血清25（OH）VitD3水平对儿童呼吸道感染常见症状和体液免疫的影响[J].医学信息,2022,35(04):89-91,97.[doi:10.3969/j.issn.1006-1959.2022.04.022]
　HE Tian-tian,SHI Hui-min,GAN Wei-hua,et al.Effect of Serum 25(OH)VitD3 Level on Common Symptoms and Humoral Immunity of Childrenwith Respiratory Tract Infection[J].Medical Information,2022,35(04):89-91,97.[doi:10.3969/j.issn.1006-1959.2022.04.022]
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血清25（OH）VitD3水平对儿童呼吸道感染常见症状和体液免疫的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
89-91,97
栏目:
论著
出版日期:
2022-02-15

文章信息/Info

Title:
Effect of Serum 25(OH)VitD3 Level on Common Symptoms and Humoral Immunity of Childrenwith Respiratory Tract Infection
文章编号:
1006-1959（2022）04-0089-04
作者:
何田田; 施会敏; 甘卫华; 张爱青; 李善文
南京医科大学第二附属医院儿科，江苏 南京 210003
Author(s):
HE Tian-tian; SHI Hui-min; GAN Wei-hua; ZHANG Ai-qing; LI Shan-wen
Department of Pediatrics,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210003,Jangsu,China
关键词:
25（OH）VitD3; 呼吸道感染; 体液免疫; C-反应蛋白
Keywords:
25(OH)VitD3; Respiratory tract infection; Humoral immunity; C-reactive protein
分类号:
R725
DOI:
10.3969/j.issn.1006-1959.2022.04.022
文献标志码:
A
摘要:
目的 探讨不同水平血清25（OH）VitD3对儿童呼吸道感染常见症状和体液免疫的影响。方法 选择2018年12月-2019年8月南京医科大学第二附属医院儿科收治67例呼吸道感染儿童作为研究对象，根据患儿血清25（OH）VitD3水平将其分为充足组（36例）和不足组（31例），比较两组血清IgA、IgG、IgM及末梢血C-反应蛋白（CRP）水平，比较不同呼吸道感染症状的儿童血清25（OH）VitD3水平，分析血清25（OH）VitD3水平与免疫指标的相关性。结果 充足组IgA、IgG、IgM水平均高于不足组，血清CRP水平低于不足组，差异有统计学意义（P＜0.05）；有喘息症状的儿童血清25（OH）VitD3水平低于无喘息者，差异有统计学意义（P＜0.05）；有无发热或咳嗽症状患儿血清25（OH）VitD3水平比较，差异无统计学意义（P＞0.05）；血清25（OH）VitD3水平与IgA、IgG呈正相关，与CRP水平呈负相关，与IgM无相关性。结论 血清25（OH）VitD3水平不足可导致儿童体液免疫能力下降，引起患儿呼吸道感染时炎症反应增强，此类患儿更容易出现喘息症状。
Abstract:
Objective To investigate the effect of different levels of serum 25(OH)VitD3 on common symptoms and humoral immunity in children with respiratory tract infection.Methods A total of 67 children with respiratory tract infection admitted to the Department of Pediatrics of the Second Affiliated Hospital of Nanjing Medical University from December 2018 to August 2019 were selected as the research objects. According to the serum 25(OH)VitD3 level of children, they were divided into sufficient group (36 cases) and insufficient group (31 cases). The serum IgA, IgG, IgM and peripheral blood C-reactive protein (CRP) levels of the two groups were compared. The serum 25(OH)VitD3 levels of children with different respiratory tract infection symptoms were compared. The correlation between serum 25(OH)VitD3 level and immune indexes was analyzed.Results The levels of IgA, IgG and IgM in the sufficient group were higher than those in the insufficient group, and the serum CRP level was lower than that in the insufficient group, the difference was statistically significant (P<0.05). The serum 25(OH)VitD3 level in children with wheezing symptoms was lower than that in children without wheezing, and the difference was statistically significant (P<0.05). There was no significant difference in serum 25(OH)VitD3 level between children with or without fever or cough symptoms (P>0.05). Serum 25(OH)VitD3 level was positively correlated with IgA and IgG, negatively correlated with CRP, and had no correlation with IgM.Conclusion The insufficient of serum 25(OH)VitD3 can lead to a decrease in humoral immunity in children, which may lead to an increased inflammatory response in children with respiratory tract infection,and may easy to cause the occurrence of wheezing symptoms.

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更新日期/Last Update: 1900-01-01