[1]黄 丹,王 璞.肉芽肿性肺疾病的研究现状[J].医学信息,2022,35(05):44-48.[doi:10.3969/j.issn.1006-1959.2022.05.011]
 HUANG Dan,WANG Pu.Research Status of Granulomatous Lung Disease[J].Medical Information,2022,35(05):44-48.[doi:10.3969/j.issn.1006-1959.2022.05.011]
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肉芽肿性肺疾病的研究现状()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
44-48
栏目:
综述
出版日期:
2022-03-01

文章信息/Info

Title:
Research Status of Granulomatous Lung Disease
文章编号:
1006-1959(2022)05-0044-05
作者:
黄 丹王 璞
(重庆医科大学附属第一医院呼吸与危重症医学科,重庆 400016)
Author(s):
HUANG DanWANG Pu
(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
关键词:
肉芽肿性肺疾病结核分枝杆菌真菌感染结节病
Keywords:
Granulomatous lung diseaseMycobacterium tuberculosisFungal infectionSarcoidosis
分类号:
R653.9
DOI:
10.3969/j.issn.1006-1959.2022.05.011
文献标志码:
A
摘要:
肉芽肿性肺疾病(GLD)病因广泛,大致分为感染性疾病、非感染性疾病两类,其诊断困难,且易误诊、误治,给患者、家庭及社会带来沉重负担。临床-影像-病理多学科合作诊疗、相关检查手段的合理应用有助于提高GLD的诊断准确率。本文主要就GLD的病因及诊断作一综述,以期为临床诊疗提供参考。
Abstract:
Granulomatous lung disease (GLD) has a wide range of causes, which can be roughly divided into infectious diseases and non-infectious diseases.The diagnosis of GLD is difficult, and it is easy to be misdiagnosed and mistreated, which brings heavy burden to patients, families and society. The reasonable application of clinical-imaging-pathological multidisciplinary cooperation in diagnosis and treatment and related examination methods helps to improve the diagnostic accuracy of GLD. This article reviews the etiology and diagnosis of GLD in order to provide reference for clinical diagnosis and treatment.

参考文献/References:

[1]de Oliveira CV,Horvat N,Testagrossa LA,et al.Etiological profile and main imaging findings in patients with granulomatous diseases who underwent lung biopsy[J].Eur J Radiol Open,2021(8):100325.[2]Grosu HB,Ost DE,Morice RC,et al.Mediastinal Granulomatous Inflammation and Overall Survival in Patients with a History of Malignancy[J].Ann Am Thorac Soc,2015,12(10):1534-1541. [3]Chopra A,Avadhani V,Tiwari A,et al.Granulomatous lung disease: clinical aspects[J].Expert Rev Respir Med,2020,14(10):1045-1063. [4]Mukhopadhyay S,Farver CF,Vaszar LT,et al.Causes of pulmonary granulomas: a retrospective study of 500 cases from seven countries[J].J Clin Pathol,2012,65(1):51-57. [5]Al-Harbi A,Al-Otaibi S,Abdulrahman A,et al.Lung granuloma: A clinicopathologic study of 158 cases[J].Ann Thorac Med,2017,12(4):278-281.[6]Nazarullah A,Nilson R,Maselli DJ,et al.Incidence and aetiologies of pulmonary granulomatous inflammation: a decade of experience[J].Respirology,2015,20(1):115-121.[7]Lederer DJ,Martinez FJ.Idiopathic Pulmonary Fibrosis[J].N Engl J Med,2018,378(19):1811-1823.[8]Harding E.WHO global progress report on tuberculosis elimination[J].Lancet Respir Med,2020,8(1):19. [9]中华医学会结核病学分会,结核病病理学诊断专家共识编写组.中国结核病病理学诊断专家共识[J].中华结核和呼吸杂志,2017,40(6):419-425. [10]Romdhane E,Rammeh S,Riahi H,et al.The Value of Histology in the Diagnosis of Tuberculous Spondylodiscitis[J].J Clin Rheumatol,2020,26(2):63-66. [11]Narang S,Solanki A,Kashyap S,et al.Utility of fine needle aspiration cytology to comprehend the pathogenesis of extrapulmonary tuberculosis[J].Diagn Cytopathol,2016,44(2):98-102. [12]Krishna M,Gole SG.Comparison of Conventional Ziehl-Neelsen Method of Acid Fast Bacilli with Modified Bleach Method in Tuberculous Lymphadenitis[J].J Cytol,2017,34(4):188-192.[13]娄丽萍,张文迪.石蜡包埋组织实时荧光定量PCR技术在结核病诊断中的应用[J].锦州医科大学学报,2019,40(3):74-76[14]李雪,孟禹彤,周翔,等.结核病病理诊断的新方法研究[J].诊断病理学杂志,2020,27(5):300-305.[15]Donohue MJ.Increasing nontuberculous mycobacteria reporting rates and species diversity identified in clinical laboratory reports[J].BMC Infect Dis,2018,18(1):163.[16]Hermansen TS,Ravn P,Svensson E,et al.Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century[J].Sci Rep,2017,7(1):6696. [17]Yu X,Liu P,Liu G,et al.The prevalence of non-tuberculous mycobacterial infections in mainland China: Systematic review and meta-analysis[J].J Infect,2016,73(6):558-567.[18]Huang HL,Cheng MH,Lu PL,et al.Epidemiology and Predictors of NTM Pulmonary Infection in Taiwan-a Retrospective, Five-Year Multicenter Study[J].Sci Rep,2017,7(1):16300. [19]李多,房坤,王珏,等.非结核分枝杆菌肺病的CT分型及其临床特征分析(附132例报告)[J].中国防痨杂志,2019,41(2):202-209.[20]Ciet P,Serra G,Bertolo S,et al.Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT[J].Eur Radiol,2016,26(3):780-787. [21]Campo M.What is Nontuberculous Mycobacteria(NTM) Disease[J].Am J Respir Crit Care Med,2017(195):17-18.[22]中华医学会结核病学分会.非结核分枝杆菌病诊断与治疗指南(2020年版)[J].中华结核和呼吸杂志,2020,43(11):918-946. [23]王翠萍,邵汇琳,王澎,等.组织病理学诊断的肺真菌病187例菌种分布的回顾性分析[J].中华结核和呼吸杂志,2021,44(1):28-31. [24]林鹏程,叶君如,周颖,等.接受抗真菌药物治疗肺隐球菌病患者胸部CT和隐球菌荚膜抗原滴度的动态观察[J].中华医学杂志,2019,99(26):2036-2041. [25]傅顺金,许攀峰,周华,等.52例肺隐球菌病的临床及影像特点与隐球菌荚膜抗原检测结果的关系[J].中华医院感染学杂志,2018,28(22):3397-3400,3409. [26]徐建平,宋蓉蓉,赵洁婷,等.肺隐球菌病37例临床病理分析[J].临床与实验病理学杂志,2017,33(9):1041-1043.[27]李晓光,谢宗玉,康厚艺,等.原发性肺隐球菌病的CT影像和病理表现[J].蚌埠医学院学报,2019,44(11):1513-1517.[28]邸小青,甘思远,叶瑞芳,等.肺原发性隐球菌病患者临床病理及影像学特征分析[J].中国病原生物学杂志,2019,14(6):639-642.[29]Sun KS,Tsai CF,Chen SC,et al.Correction: Galactomannan Testing and the Incidence of Invasive Pulmonary Aspergillosis: A 10-Year Nationwide Population-Based Study in Taiwan[J].PLoS One,2016,11(6):e0156566.[30]潘玲,卢岳虹,宋策,等.支气管镜下肺泡灌洗液半乳甘露聚糖试验联合(1,3)-β-D葡聚糖检测对肺曲霉菌病的诊断价值[J].中国内镜杂志,2019,25(8):5-9.[31]张健雄,李云霄,王浩彦.66例结节病首发表现与首诊科室回顾分析[J].心肺血管病杂志,2018,37(1):29-32.[32]中华医学会呼吸病学分会间质性肺疾病学组,中国医师协会呼吸医师分会间质性肺疾病工作委员会.中国肺结节病诊断和治疗专家共识[J].中华结核和呼吸杂志,2019,42(9):685-693.[33]Spagnolo P,Rossi G,Trisolini R,et al.Pulmonary sarcoidosis[J].Lancet Respir Med,2018,6(5):389-402.[34]Aleksoniene R,Zeleckiene I,Mataciūnas M,et al.Relationship between radiologic patterns, pulmonary function values and bronchoalveolar lavage fluid cells in newly diagnosed sarcoidosis[J].J Thorac Dis,2017,9(1):88-95.[35]Ramos-Casals M,Retamozo S,Sisó-Almirall A,et al.Clinically-useful serum biomarkers for diagnosis and prognosis of sarcoidosis[J].Expert Rev Clin Immunol,2019,15(4):391-405.[36]Li CW,Tao RJ,Zou DF,et al.Pulmonary sarcoidosis with and without extrapulmonary involvement: a cross-sectional and observational study in China[J].BMJ Open,2018,8(2):e018865. [37]Eurelings LEM,Miedema JR,Dalm VASH,et al.Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis[J].PLoS One,2019,14(10):e0223897. [38]Sun J,Yang H,Teng J,et al.Determining factors in diagnosing pulmonary sarcoidosis by endobronchial ultrasound-guided transbronchial needle aspiration[J].Ann Thorac Surg,2015,99(2):441-445. [39]Batum O,Katgi N,Ozdemir O,et al.Diagnostic efficacy of EBUS-TBNA in benign diseases in a population with a high prevalence of tuberculosis[J].Diagn Cytopathol,2021,49(3):374-380. [40]Li J,Li C,Li J.Thoracic manifestation of Wegener’s granulomatosis: Computed tomography findings and analysis of misdiagnosis[J].Exp Ther Med,2018,16(1):413-419.[41]Solans-Laqué R,Fraile G,Rodriguez-Carballeira M,et al.Clinical characteristics and outcome of Spanish patients with ANCA-associated vasculitides: Impact of the vasculitis type, ANCA specificity, and treatment on mortality and morbidity[J].Medicine (Baltimore),2017,96(8):e6083. [42]Furuta S,Iwamoto T,Nakajima H.Update on eosinophilic granulomatosis with polyangiitis[J].Allergol Int,2019,68(4):430-436. [43]Trivioli G,Terrier B,Vaglio A.Eosinophilic granulomatosis with polyangiitis: understanding the disease and its management[J].Rheumatology (Oxford),2020,59(Suppl 3):iii84-iii94. [44]张立春,高峰.嗜酸性肉芽肿性多血管炎186例临床荟萃分析[J].中国呼吸与危重监护杂志,2017,16(5):505-508.[45]刘启梁,雷美.首诊误诊为淋巴结核的25例淋巴结恶性肿瘤原因分析[J].临床误诊误治,2020,33(1):8-11.[46]杨春蓉,郑晓丹,胡余昌,等.肺淋巴瘤样肉芽肿5例临床病理分析[J].临床与实验病理学杂志,2016,32(8):924-926,930.[47]Kovacs A,Baksay B,Cserenyecz A,et al.Occurrence of pulmonary rheumatoid nodules following biological therapies[J].Clin Rheumatol,2015(34):1639-1642.[48]何善智,丁菱,王敏,等.类风湿关节炎合并肺部类风湿结节的危险因素分析[J].实用医学杂志,2017,33(10):1665-1668.[49]Chopra A,Avadhani V,Tiwari A,et al.Granulomatous lung disease: clinical aspects[J].Expert Rev Respir Med,2020,14(10):1045-1063. [50]Aubry MC.Necrotizing granulomatous inflammation: what does it mean if your special stains are negative?[J].Mod Pathol,2012(25 Suppl 1):S31-S38. [51]Miao Q,Ma Y,Wang Q,et al.Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice[J].Clin Infect Dis,2018,67(suppl_2):S231-S240.[52]Chen P,Sun W,He Y.Comparison of the next-generation sequencing (NGS) technology with culture methods in the diagnosis of bacterial and fungal infections[J].J Thorac Dis,2020,12(9):4924-4929.

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更新日期/Last Update: 1900-01-01