[1]汪晶晶,孙礼宾.NLR、PLR与LMR在儿童过敏性紫癜肾损害中的相关性[J].医学信息,2022,35(05):111-113.[doi:10.3969/j.issn.1006-1959.2022.05.028]
　WANG Jing-jing,SUN Li-bin.Correlation of NLR, PLR and LMR in Renal Damage of Children with Henoch-Schonlein Purpura[J].Medical Information,2022,35(05):111-113.[doi:10.3969/j.issn.1006-1959.2022.05.028]
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NLR、PLR与LMR在儿童过敏性紫癜肾损害中的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
111-113
栏目:
论著
出版日期:
2022-03-01

文章信息/Info

Title:
Correlation of NLR, PLR and LMR in Renal Damage of Children with Henoch-Schonlein Purpura
文章编号:
1006-1959（2022）05-0111-03
作者:
汪晶晶; 孙礼宾
（安徽医科大学附属巢湖医院儿科，安徽 合肥 238000）
Author(s):
WANG Jing-jing; SUN Li-bin
(Department of Pediatrics,Chaohu Hospital of Anhui Medical University,Anhui 238000,Hefei,China)
关键词:
过敏性紫癜; 肾损害; 中性粒细胞/淋巴细胞比值; 血小板/淋巴细胞比值; 淋巴细胞/单核细胞比值
Keywords:
Henoch-Sch?觟nlein purpura; Renal damage; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio; Lymphocyte-monocyte ratio
分类号:
R725.5
DOI:
10.3969/j.issn.1006-1959.2022.05.028
文献标志码:
A
摘要:
目的 探讨中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）与淋巴细胞/单核细胞比值（LMR）在儿童过敏性紫癜（HSP）肾损害的预测价值。方法 选取2016年6月-2021年6月安徽医科大学附属巢湖医院儿科初次诊断为HSP的180例患儿为研究对象，根据是否发生肾损害分为肾损害组（n=30）和非肾损害组（n=150），比较两组血常规指标，采用二元Logistic回归分析及ROC曲线分析各指标对儿童HSP肾损害中的预测价值。结果 肾损害组WBC、NEU、MONO、PLT、NLR、PLR高于非肾损害组，LYM、LMR低于非肾损害组，差异有统计学意义（P＜0.05）；二元Logistic回归分析显示，NLR、PLR、LMR是HSP肾损害的影响因素（P＜0.05）；ROC曲线分析显示，NLR、PLR、LMR及三者联合检测的AUC分别为0.831、0.809、0.785、0.846，其中NLR为HSP肾损害的单个最佳预测因子，其特异度为72.70%，敏感度为80.00%，最佳临界值为2.48。结论 NLR、PLR、LMR与HSP肾损害相关，是发生肾损害的危险因素，三者联合检测对临床诊断HSP肾损害有一定的价值。
Abstract:
Objective To investigate the predictive value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) in renal damage in children with Henoch-Sch?觟nlein purpura (HSP).Methods A total of 180 children with HSP initially diagnosed in Department of Pediatrics of Chaohu Hospital Affiliated to Anhui Medical University from June 2016 to June 2021 were selected as the research objects. They were divided into renal damage group (n=30) and non-renal damage group (n=150) according to whether renal damage occurred. The blood routine indexes of the two groups were compared. Binary logistic regression analysis and ROC curve were used to analyze the predictive value of each index in children with HSP renal damage.Results WBC, NEU, MONO, PLT, NLR and PLR in renal damage group were higher than those in non-renal damage group, LYM and LMR were lower than those in non-renal damage group, the differences were statistically significant (P<0.05). Binary Logistic regression analysis showed that NLR, PLR and LMR were the influencing factors of renal damage in HSP (P<0.05). ROC curve analysis showed that the AUC of NLR, PLR, LMR and their combined detection were 0.831, 0.809, 0.785 and 0.846, respectively. NLR was the single best predictor of renal damage in HSP, and its specificity was 72.70%, sensitivity was 80.00%, and the optimal critical value was 2.48.Conclusion NLR, PLR and LMR are related to renal damage of HSP, and they are risk factors for renal damage. The combined detection of NLR, PLR and LMR has certain value in clinical diagnosis of renal damage of HSP.

参考文献/References:

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更新日期/Last Update: 1900-01-01