[1]张 彤.利拉鲁肽联合胰岛素治疗新诊断肥胖2型糖尿病的临床疗效及安全性[J].医学信息,2022,35(05):159-161.[doi:10.3969/j.issn.1006-1959.2022.05.042]
 ZHANG Tong.Clinical Efficacy and Safety of Liraglutide Combined with Insulin in the Treatment of Newly Diagnosed Obese Type 2 Diabetes Mellitus[J].Medical Information,2022,35(05):159-161.[doi:10.3969/j.issn.1006-1959.2022.05.042]
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利拉鲁肽联合胰岛素治疗新诊断肥胖2型糖尿病的临床疗效及安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
159-161
栏目:
药物与临床
出版日期:
2022-03-01

文章信息/Info

Title:
Clinical Efficacy and Safety of Liraglutide Combined with Insulin in the Treatment of Newly Diagnosed Obese Type 2 Diabetes Mellitus
文章编号:
1006-1959(2022)05-0159-03
作者:
张 彤
(天津市东丽区中医医院药剂科,天津 300300)
Author(s):
ZHANG Tong
(Department of Pharmacy,Dongli District Hospital of Traditional Chinese Medicine,Tianjin 300300,China)
关键词:
利拉鲁肽胰岛素肥胖2型糖尿病血糖血脂
Keywords:
LiraglutideInsulinObesityType 2 diabetes mellitusBlood glucoseBlood lipids
分类号:
R587.1;R977.1+5
DOI:
10.3969/j.issn.1006-1959.2022.05.042
文献标志码:
A
摘要:
目的 观察利拉鲁肽联合胰岛素治疗新诊断肥胖2型糖尿病的临床疗效及安全性。方法 选取2020年5月-2021年5月在我院诊治的64例新诊断肥胖2型糖尿病患者为研究对象,采用随机数字表法分为对照组和观察组,各32例。对照组采用胰岛素治疗,观察组在对照组基础上联合利拉鲁肽治疗,比较两组临床治疗总有效率、空腹血糖(FPG)水平、餐后2h血糖(2hPG)水平、糖化血红蛋白水平(HbA1c)、体质量指数(BMI)、血脂指标,以及临床不良反应发生情况。结果 观察组总有效率为87.50%,高于对照组的78.13%,差异有统计学意义(P<0.05); 两组FPG、2hPG、HbA1c、BMI均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组LDL-C、TG、TC均低于治疗前,HDL-C均高于治疗前,且观察组LDL-C、TG、TC低于对照组,HDL-C高于对照组,差异有统计学意义(P<0.05);观察组临床不良反应发生率为6.25%,低于对照组的15.63%,差异有统计学意义(P<0.05)。结论 利拉鲁肽联合胰岛素治疗新诊断肥胖2型糖尿病效果确切,可降低不良反应,提高治疗总有效率,促进血糖水平控制,改善血脂指标,具有良好的有效性和安全性。
Abstract:
Objective To observe the clinical efficacy and safety of liraglutide combined with insulin in the treatment of newly diagnosed obese type 2 diabetes mellitus.Methods A total of 64 newly diagnosed obese patients with type 2 diabetes mellitus in our hospital from May 2020 to May 2021 were selected and randomly divided into control group and observation group, with 32 cases in each group. The control group was treated with insulin, and the observation group was treated with liraglutide on the basis of the control group. The total effective rate, fasting plasma glucose (FPG) level, postprandial 2h plasma glucose (2hPG) level, glycosylated hemoglobin level (HbA1c), body mass index (BMI), blood lipid indexes and clinical adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 87.50%, which was higher than 78.13% of the control group, and the difference was statistically significant (P<0.05). FPG, 2 hPG, HbA1c and BMI in the two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were statistically significant (P<0.05). LDL-C, TG and TC in the two groups were lower than those before treatment, HDL-C was higher than that before treatment, and LDL-C, TG and TC in the observation group were lower than those in the control group, HDL-C was higher than that in the control group, the difference was statistically significant (P<0.05). The incidence of clinical adverse reactions in the observation group was 6.25%, which was lower than 15.63% in the control group, and the difference was statistically significant (P<0.05).Conclusion Liraglutide combined with insulin is effective in the treatment of newly diagnosed obese type 2 diabetes mellitus, which can reduce adverse reactions, improve the total effective rate of treatment, promote the control of blood glucose level and improve blood lipid indexes. It has good efficacy and safety.

参考文献/References:

[1]崔克勤,王海燕,唐键,等.利拉鲁肽单药治疗新诊超重或肥胖2型糖尿病的效果及安全性观察[J].山东医药,2016,56(30):47-49.[2]王施劭锋,陈根本,柯涓,等.利拉鲁肽联合甘精胰岛素对新诊断2型糖尿病的疗效观察[J].重庆医学,2017,46(20):2770-2773.[3]张雨薇,周广举,童南伟.中国成人糖尿病患者动脉粥样硬化脑心血管疾病分级预防指南解读[J].中国实用内科杂志,2016,36(6):453-457.[4]高会敏,尚勇.利拉鲁肽和格列美脲治疗2型糖尿病的效果及其安全性比较[J].医学综述,2016,22(13):2696-2698.[5]朱剑兰.利拉鲁肽治疗初诊超重或肥胖2型糖尿病的疗效与体质指数、血脂及炎性因子变化[J].菏泽医学专科学校学报,2017,29(4):36-38.[6]郭阳阳,陶晓燕,潘天荣,等.利拉鲁肽对超重及肥胖2型糖尿病患者体质量和胰岛素抵抗的影响[J].安徽医学,2017,38(2):162-165.[7]司敏,廖勇敢,杨华.利拉鲁肽联合二甲双胍治疗初诊肥胖2型糖尿病患者的临床疗效[J].中国老年保健医学,2017,15(3):39-41.[8]陶蕾,张宏江,范中阳.利拉鲁肽联合胰岛素治疗肥胖2型糖尿病的疗效[J].医学信息,2021,34(23):99-101.[9]Yu H,Xie LF,Chen K,et al.Initiating characteristics of early-onset type 2 diabetes mellitus in Chinese patients[J].Chin Med J(Engl),2016,129(7):778-784.[10]杜宣.利拉鲁肽对2型糖尿病合并肥胖患者内脏脂肪代谢中的作用及机制研究[D].苏州:苏州大学,2018.[11]胡跃霜,钟兴,潘天荣.艾塞那肽治疗2型糖尿病合并非酒精性脂肪性肝病患者的疗效观察[J].安徽医科大学学报,2017,52(4):546-549.[12]Garber AJ,Abrahamson MJ,Barzilay JI,et al.AACE/ACE comprehensive diabetes management algorithm 2016[J].Endocr Pract,2016,21(4):438-447.[13]张红敏,吴锦林,张兴渝,等.利拉鲁肽联合二甲双胍对2糖尿病合并肥胖患者胰岛β细胞功能以及内脏脂肪水平的影响[J].中华细胞与干细胞杂志,2019,9(3):144-148.[14]陈彦平.利拉鲁肽与胰岛素治疗2型糖尿病的疗效比较[J].贵阳医学院学报,2017,42(6):741-744.[15]沈艳军,田亚强,李英,等.利拉鲁肽在新诊断2型糖尿病强化治疗后长期临床缓解中的疗效观察[J].中华糖尿病杂志,2017,9(9):550-554.[16]孙晓方,王越,赵文娟,等.利拉鲁肽对肥胖2型糖尿病患者胰高血糖素分泌功能的影响[J].中华内科杂志,2019,58(1):33-38.[17]金康,张力双,董丽娜,等.利拉鲁肽联合甘精胰岛素治疗2型糖尿病合并肥胖患者效果及对胰岛功能的影响[J].河北医科大学学报,2019,40(6):642-645.[18]何慧,张韶君,杨艳兰.利拉鲁肽与胰岛素强化治疗对新发肥胖2型糖尿病患者临床疗效的比较[J].中国药物与临床,2019,19(1):57-59.[19]徐礼五,钟兴,齐晓玲,等.新诊断超重/肥胖2型糖尿病在短期胰岛素强化治疗后转换不同降糖方案的临床疗效和安全性研究[J].安徽医科大学学报,2019,54(2):139-142.[20]徐玉凤.西格列汀联合二甲双胍治疗肥胖型2型糖尿病的临床研究[J].现代诊断与治疗,2015,26(10):2271-2273.

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更新日期/Last Update: 1900-01-01