[1]余 露,胡汉金.乳腺癌MRI影像学特征与病理分子亚型的相关性研究[J].医学信息,2022,35(08):79-84.[doi:10.3969/j.issn.1006-1959.2022.08.019]
　YU Lu,HU Han-jin.Correlation of MRI Features and Molecular Typing of Breast Cancer[J].Medical Information,2022,35(08):79-84.[doi:10.3969/j.issn.1006-1959.2022.08.019]
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乳腺癌MRI影像学特征与病理分子亚型的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年08期
页码:
79-84
栏目:
论著
出版日期:
2022-04-15

文章信息/Info

Title:
Correlation of MRI Features and Molecular Typing of Breast Cancer
文章编号:
1006-1959（2022）08-0079-06
作者:
余 露; 胡汉金
（安徽医科大学附属安庆医院影像科，安徽 安庆 246003）
Author(s):
YU Lu; HU Han-jin
(Department of Imaging,Anqing Hospital Affiliated to Anhui Medical University,Anqing 246003,Anhui,China)
关键词:
乳腺癌; 磁共振成像; 分子分型; 表观扩散系数; 早期强化率
Keywords:
Breast cancer; Magnetic resonance imaging; Molecular typing; Apparent diffusion coefficient; Early enhancement rate
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2022.08.019
文献标志码:
A
摘要:
目的 探讨乳腺癌的MRI影像学特征与其病理分子亚型的相关性。方法 回顾性分析本院2019年1月-2021年4月经手术证实为乳腺癌的160例患者临床资料。根据免疫组化结果分为Luminal A型、Luminal B型、人表皮生长因子受体2（HER-2）过表达型、三阴性型，比较不同分子分型乳腺癌MRI影像特征、表观扩散系数（ADC）值及早期强化率（EER）值，采用ROC曲线评估ADC值及EER值鉴别HER-2过表达型乳腺癌的诊断效能。结果 不同分子分型乳腺癌患者淋巴结情况、病灶大小、病灶类型、肿块样病灶的形态、边缘和内部强化、瘤周水肿、瘤周血管异常比较，差异有统计学意义（P＜0.05）；HER-2过表达型的ADC值及EER值高于Luminal A型、Luminal B型及三阴性型，差异有统计学意义（P＜0.05）；ADC、EER及ADC+EER诊断HER-2过表达型的ROC曲线下面积（AUC）分别为0.785、0.726、0.835，其中ADC+EER联合鉴别效能最佳。结论 不同分子亚型乳腺癌MRI影像表现具有一定特征性，根据MRI影像特征及ADC值、EER值有助于鉴别乳腺癌分子亚型。
Abstract:
Objective To analyze the MRI features of breast cancer, and to explore the relationship between them and indifferent molecular types. Methods The clinical data of 160 patients with breast cancer confirmed by surgery in our hospital from January 2019 to April 2021 were retrospectively analyzed. According to the immunohistochemical results, they were divided into Luminal A type, Luminal B type, human epidermal growth factor receptor 2 (HER-2) overexpression type and triple negative type. The MRI imaging features, apparent diffusion coefficient (ADC) values and early enhancement rate (EER) values of breast cancer with different molecular types were compared. ROC curve was used to evaluate the diagnostic efficacy of ADC values and EER values in distinguishing HER-2 overexpression breast cancer.Results There were significant differences in lymph node status, lesion size, lesion type, the shape, edge and internal enhancement of mass-like lesion, peritumoral edema and peritumoral vascular abnormalities among different molecular subtypes of breast cancer (P<0.05). The ADC value and EER value of HER-2 overexpression type were higher than those of Luminal A type, Luminal B type and triple negative type, and the difference was statistically significant (P<0.05). The area under the ROC curve (AUC) of ADC, EER and ADC+EER in the diagnosis of HER-2 overexpression were 0.785, 0.726 and 0.835, respectively; the combination of ADC and EER was the best.Conclusion Different molecular subtypes of breast cancer have certain characteristics on MRI. According to the MRI features, ADC and EER, the molecular classification can be preliminarily identified.

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更新日期/Last Update: 1900-01-01