[1]刘洪玮,陈 蕾.ICAM-1在结直肠癌组织中的表达及意义[J].医学信息,2022,35(16):43-46.[doi:10.3969/j.issn.1006-1959.2022.16.009]
　LIU Hong-wei,CHEN Lei.The Expression and Significance of ICAM-1 in Colorectal Cancer Tissues[J].Journal of Medical Information,2022,35(16):43-46.[doi:10.3969/j.issn.1006-1959.2022.16.009]
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ICAM-1在结直肠癌组织中的表达及意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
43-46
栏目:
论著
出版日期:
2022-08-15

文章信息/Info

Title:
The Expression and Significance of ICAM-1 in Colorectal Cancer Tissues
文章编号:
1006-1959（2022）16-0043-04
作者:
刘洪玮; 陈 蕾
（潍坊医学院附属医院麻醉科1，血液科2，山东 潍坊 261031）
Author(s):
LIU Hong-wei; CHEN Lei
(Department of Anesthesiology1,Department of Hematology2,Affiliated Hospital of Weifang Medical College,Weifang 261031,Shandong,China)
关键词:
结直肠癌; 细胞间黏附分子-1; 淋巴结转移
Keywords:
Colon cancer; Intercellular adhesion molecule-1; Lymphatic metastasis
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2022.16.009
文献标志码:
A
摘要:
目的 探讨细胞间黏附分子-1（ICAM-1）在结直肠癌组织与癌旁组织中表达及意义。方法 选取2020年1月-8月潍坊医学院附属医院病理科保存的手术切除的结直肠癌组织标本30例，每例标本同时取距癌组织边缘2 cm处的癌旁组织做对照，采用免疫组织化学技术检测ICAM-1在结直肠癌组织与癌旁组织中的表达情况，分析其与患者临床病理指标的关系。结果 ICAM-1呈散在分布的淡黄色或棕黄色颗粒，主要定位于细胞膜上，在胞浆和间质中也有表达，阴性对照片中未见黄色颗粒。ICAM-1在结直肠癌组织中的阳性表达率为70.00%（21/30），在癌旁组织中阳性率为33.33%（10/30），差异有统计学意义（P＜0.05），ICAM-1在肿瘤淋巴结转移组织中的表达率高于无淋巴结转移组织，差异有统计学意义（P＜0.05），但不同性别、年龄、组织学类型、病理分级以及TNM分期间ICAM-1表达比较，差异无统计学意义（P＞0.05）。结论 ICAM-1在结直肠癌组织中高表达，且与患者淋巴结转移有关，提示ICAM-1可能在结直肠癌的发生与发展过程中起重要作用。
Abstract:
Objective To investigate the expression and significance of intercellular adhesion molecule-1 (ICAM-1) in colorectal carcinoma and adjacent tissues.Methods Thirty specimens of surgically removed colorectal cancer tissues were selected from the Department of Pathology, Affiliated Hospital of Weifang Medical College from January to August 2020. At the same time, adjacent tissues 2 cm from the edge of the cancer tissues were taken from each specimen as controls. The expression of ICAM-1 in colorectal cancer tissues and adjacent tissues was detected by immunohistochemistry, and its relationship with clinicopathological parameters of patients was analyzed.Results ICAM-1 was scattered in the distribution of light yellow or brown granules, mainly located in the cell membrane, also expressed in the cytoplasm and interstitial. The positive expression rate of ICAM-1 in colorectal cancer tissues was 70.00%, and the positive rate in adjacent tissues was 33.33%, the difference was statistically significant (P<0.05). The expression rate of ICAM-1 in tumor lymph node metastasis tissues was higher than that in non-lymph node metastasis tissues, and the difference was statistically significant (P<0.05). However, there was no significant difference in ICAM-1 expression between different genders, ages, histological types, pathological grades and TNM stages (P>0.05).Conclusion ICAM-1 is highly expressed in colorectal cancer tissues and is related to lymph node metastasis, suggesting that ICAM-1 may play an important role in the occurrence and development of colorectal cancer.

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更新日期/Last Update: 1900-01-01