[1]刘 倩,夏海龙.硼替佐米对多发性骨髓瘤患者认知功能的影响及与血清脑源性神经营养因子的相关性[J].医学信息,2023,36(07):105-109.[doi:10.3969/j.issn.1006-1959.2023.07.019]
　LIU Qian,XIA Hai-long.Effect of Bortezomib on Cognitive Function in Patients with Multiple Myeloma and its Correlation with Serum Brain-derived Neurotrophic Factor[J].Journal of Medical Information,2023,36(07):105-109.[doi:10.3969/j.issn.1006-1959.2023.07.019]
点击复制

硼替佐米对多发性骨髓瘤患者认知功能的影响及与血清脑源性神经营养因子的相关性()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年07期
页码:
105-109
栏目:
论著
出版日期:
2023-04-01

文章信息/Info

Title:
Effect of Bortezomib on Cognitive Function in Patients with Multiple Myeloma and its Correlation with Serum Brain-derived Neurotrophic Factor
文章编号:
1006-1959（2023）07-0105-05
作者:
刘 倩; 夏海龙
（1.安徽医科大学附属巢湖医院血液内科，安徽 巢湖 238001；2.安徽医科大学第一附属医院血液内科，安徽 合肥 230022）
Author(s):
LIU Qian; XIA Hai-long
(1.Department of Hematology,Chaohu Hospital of Anhui Medical University,Chaohu 238001,Anhui,China;2.Department of Hematology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
关键词:
硼替佐米; 认知功能; 多发性骨髓瘤; 脑源性神经营养因子
Keywords:
Bortezomib; Cognitive function; Multiple myeloma; Brain-derived neurotrophic factor
分类号:
R733.3
DOI:
10.3969/j.issn.1006-1959.2023.07.019
文献标志码:
A
摘要:
目的 探索硼替佐米对多发性骨髓瘤（MM）患者认知功能的影响及与血清脑源性神经营养因子（BDNF）水平变化的相关性。方法 选择2021年8月-2022年8月收治的MM患者90例作为观察组，另选同期健康体检者30名作为健康对照组。观察组根据是否采用硼替佐米化疗以及化疗疗程分为初诊MM组（30例）、化疗疗程≤4组（30例）和化疗疗程＞4组（30例）。比较健康对照组、初诊MM组、化疗疗程≤4组和化疗疗程＞4组蒙特利尔认知评估量表（MoCA）评分和血清BDNF水平，分析观察组患者的MoCA评分与血清BDNF水平的相关性。结果 观察组MoCA评分和血清BDNF水平均低于健康对照组（P＜0.05）；而初诊MM组MoCA评分与血清BDNF水平均高于化疗疗程≤4组和化疗疗程＞4组（P＜0.05），且化疗疗程＞4组MoCA评分和血清BDNF水平低于化疗疗程≤4组（P＜0.05）；Pearson相关性分析显示，观察组MoCA评分与血清BDNF水平呈正相关（r=0.588）。结论 MM患者在化疗前存在一定程度的认知功能损害。硼替佐米化疗以及化疗时间的延长可使患者的认知障碍进一步加重。硼替佐米化疗加重MM患者认知障碍与其血清BDNF水平下降具有一定的相关性。
Abstract:
Objective To explore the effect of bortezomib on cognitive function in patients with multiple myeloma (MM) and its correlation with serum brain-derived neurotrophic factor (BDNF) levels.Methods A total of 90 patients with MM from August 2021 to August 2022 were selected as the observation group, and 30 healthy people in the same period were selected as the healthy control group. The observation group was divided into newly diagnosed MM group (30 cases), chemotherapy course≤4 group (30 cases) and chemotherapy course>4 group (30 cases) according to whether bortezomib chemotherapy was used and the course of chemotherapy. The Montreal Cognitive Assessment (MoCA) score and serum BDNF level were compared among the healthy control group, newly diagnosed MM group, chemotherapy course≤4 group and chemotherapy course>4 group. The correlation between MoCA score and serum BDNF level in the observation group was analyzed.Results The MoCA score and serum BDNF level in the observation group were lower than those in the healthy control group (P<0.05). MoCA score and serum BDNF level in newly diagnosed MM group were higher than those in chemotherapy course≤4 group and chemotherapy course>4 group (P<0.05), and the MoCA score and serum BDNF level in the chemotherapy course>4 group were lower than those in the chemotherapy course≤4 group (P<0.05). Pearson correlation analysis showed that MoCA score was positively correlated with serum BDNF level in the observation group (r=0.588).Conclusion MM patients have a certain degree of cognitive impairment before chemotherapy. Bortezomib chemotherapy and the prolongation of chemotherapy time can further aggravate the cognitive impairment of patients. Bortezomib chemotherapy aggravates cognitive impairment in MM patients and has a certain correlation with the decrease of serum BDNF level.

参考文献/References:

[1]Siegel RL,Miller KD,Fuchs HE,et al.Cancer Statistics,2021[J].CA Cancer J Clin,2021,71(1):7-33.[2]Wang S,Xu L,Feng J,et al.Prevalence and Incidence of Multiple Myeloma in Urban Area in China: A National Population-Based Analysis[J].Front Oncol,2020,9:1513.[3]Cowan AJ,Allen C,Barac A,et al.Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016[J].JAMA Oncol,2018,4(9):1221-1227.[4]Callander NS,Baljevic M,Adekola K,et al.NCCN Guidelines Insights:Multiple Myeloma, Version 3.2022[J].J Natl Compr Canc Netw,2022,20(1):8-19.[5]Juan Z,Chen J,Ding B,et al.Probiotic supplement attenuates chemotherapy-related cognitive impairment in patients with breast cancer: a randomised, double-blind, and placebo-controlled trial[J].Eur J Cancer,2022,161:10-22.[6]Sales MVC,Suemoto CK,Apolinario D,et al.Effects of Adjuvant Chemotherapy on Cognitive Function of Patients With Early-stage Colorectal Cancer[J].Clin Colorectal Cancer,2019,18(1):19-27.[7]Meregalli C,Canta A,Carozzi VA,et al.Bortezomib-induced painful neuropathy in rats: a behavioral, neurophysiological and pathological study in rats[J].Eur J Pain,2010,14(4):343-350.[8]刘佳慧,樊慧守,邓书会,等.硼替佐米中枢神经系统毒性五例报告并文献复习[J].中华血液学杂志,2021,42(1):63-69.[9]刘晗,方洁,孙丽霞,等.硼替佐米联合地塞米松治疗多发性骨髓瘤出现严重精神障碍一例[J].新医学,2015,46(1):64-66.[10]Wei C,Sun Y,Chen N,et al.Interaction of oxidative stress and BDNF on executive dysfunction in patients with chronic schizophrenia[J].Psychoneuroendocrinology,2020,111:104473. [11]Yap NY,Tan NYT,Tan CJ,et al.Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in survivors of breast cancer[J].Breast Cancer Res Treat,2020,183(3):683-696. [12]Pugh EA,Kemp EC,van Dyck CH,et al.Alzheimer’s Disease Neuroimaging Initiative.Effects of Normative Adjustments to the Montreal Cognitive Assessment[J].Am J GeriatrPsychiatry,2018,26(12):1258-1267.[13]González-Santos á,Lopez-Garzon M,Sánchez-Salado C,et al.A Telehealth-Based Cognitive-Adaptive Training (e-OTCAT) to Prevent Cancer and Chemotherapy-Related Cognitive Impairment in Women with Breast Cancer: Protocol for a Randomized Controlled Trial[J].Int J Environ Res Public Health,2022,19(12):7147.[14]Dhillon HM,Tannock IF,Pond GR,et al.Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy[J].J Cancer Surviv,2018,12(2):178-185.[15]Lycke M,Pottel L,Pottel H,et al.Predictors of baseline cancer-related cognitive impairment in cancer patients scheduled for a curative treatment[J].Psychooncology,2017,26(5):632-639. [16]Beksac M,Seval GC,Kanellias N,et al.A real world multicenter retrospective study on extramedullary disease from Balkan Myeloma Study Group and Barcelona University: analysis of parameters that improve outcome[J].Haematologica,2021,106(4):1228.[17]Magyari F,Virga I,Simon Z,et al.Assessment of cognitive function in long-term Hodgkin lymphoma survivors, results based on data from a major treatment center in Hungary[J].Support Care Cancer,2022,30(6):5249-5258. [18]Huehnchen P,Boehmerle W,Springer A,et al.A novel preventive therapy for paclitaxel-induced cognitive deficits: preclinical evidence from C57BL/6 mice[J].Transl Psychiatry,2017,7(8):e1185.[19]Gozzetti A,Cerase A,Lotti F,et al.Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients[J].Cancer,2012,118(6):1574-1584.[20]Hodgson KD,Hutchinson AD,Wilson CJ,et al.A meta-analysis of the effects of chemotherapy on cognition in patients with cancer[J].Cancer Treat Rev,2013,39(3):297-304.[21]Shi DD,Huang YH,Lai CSW,et al.Chemotherapy-Induced Cognitive Impairment Is Associated with Cytokine Dysregulation and Disruptions in Neuroplasticity[J].Mol Neurobiol,2019,56(3):2234-2243.[22]Pan W,Banks WA,Fasold MB,et al.Transport of brain-derived neurotrophic factor across the blood-brain barrier[J].Neuropharmacology,1998,37(12):1553-1561.[23]仝太山,叶智存,宗剑,等.乳腺癌“化疗脑”与脑源性神经营养因子的相关性[J].西南医科大学学报,2017,40(5):472-474.

相似文献/References:

[1]王 丹,谢婷婷,张 莉.七氟醚与丙泊酚静脉麻醉对老年髋关节置换术患者 认知功能的影响[J].医学信息,2018,31(09):133.[doi:10.3969/j.issn.1006-1959.2018.09.041]
　WANG Dan,XIE Ting-ting,ZHANG Li.Effects of Sevoflurane and Propofol Intravenous Anesthesia on Cognitive Function in Elderly Patients Undergoing Hip Replacement[J].Journal of Medical Information,2018,31(07):133.[doi:10.3969/j.issn.1006-1959.2018.09.041]
[2]胡金艳,王 冬.影响老年糖尿病患者发生认知障碍的危险因素分析[J].医学信息,2018,31(16):55.[doi:10.3969/j.issn.1006-1959.2018.16.015]
　HU Jin-yan,WANG Dong.Analysis of Risk Factors Affecting Cognitive Impairment in Elderly Diabetic Patients[J].Journal of Medical Information,2018,31(07):55.[doi:10.3969/j.issn.1006-1959.2018.16.015]
[3]包娜娜,刘 超.太极拳对遗忘型轻度认知功能障碍患者认知功能影响的研究[J].医学信息,2019,32(02):115.[doi:10.3969/j.issn.1006-1959.2019.02.032]
　BAO Na-na,LIU Chao.Study on Taijiquan in Patients with Amnestic Mild Cognitive Dysfunction[J].Journal of Medical Information,2019,32(07):115.[doi:10.3969/j.issn.1006-1959.2019.02.032]
[4]杨彩霞.慢性精神分裂症患者庇护性就业训练的疗效观察[J].医学信息,2019,32(06):120.[doi:10.3969/j.issn.1006-1959.2019.06.037]
　YANG Cai-xia.Therapeutic Effect of Sheltered Employment Training for Patients with Chronic Schizophrenia[J].Journal of Medical Information,2019,32(07):120.[doi:10.3969/j.issn.1006-1959.2019.06.037]
[5]曲艳津.益肾填精法对慢性脑供血不足患者脑动力学的影响[J].医学信息,2019,32(19):160.[doi:10.3969/j.issn.1006-1959.2019.19.053]
　QU Yan-jin.Effect of Yishen Filling Method on Brain Dynamics in Patients with Chronic Cerebral Insufficiency[J].Journal of Medical Information,2019,32(07):160.[doi:10.3969/j.issn.1006-1959.2019.19.053]
[6]冯 睿,刘光维.早期康复护理在提高脑梗死患者治疗效果及改善认知功能、 日常生活能力中的作用分析[J].医学信息,2019,32(14):186.[doi:10.3969/j.issn.1006-1959.2019.14.063]
　FENG Rui,LIU Guang-wei.Analysis of the Role of Early Rehabilitation Nursing in Improving the Therapeutic Effect and Improving Cognitive Function and Daily Living Ability of Patients with Cerebral Infarction[J].Journal of Medical Information,2019,32(07):186.[doi:10.3969/j.issn.1006-1959.2019.14.063]
[7]董淑欣,吴成吉,滕立志,等.中年无症状性脑梗死事件相关电位P300变化及其与 认知功能的相关性研究[J].医学信息,2019,32(16):105.[doi:10.3969/j.issn.1006-1959.2019.16.033]
　DONG Shu-xin,WU Cheng-ji,TENG Li-zhi,et al.Changes of Event-related Potential P300 in Middle-aged Patients with Asymptomatic Cerebral Infarction and Its Correlation with Cognitive Function[J].Journal of Medical Information,2019,32(07):105.[doi:10.3969/j.issn.1006-1959.2019.16.033]
[8]黄庆松,马爱玲,张 瑞,等.合并微出血对脑小血管闭塞性卒中患者认知功能的影响及其与P300的关系[J].医学信息,2019,32(22):66.[doi:10.3969/j.issn.1006-1959.2019.22.021]
　HUANG Qing-song,MA Ai-ling,ZHANG Rui,et al.Effect of Combined Microbleeds on Cognitive Function in Patients with Cerebral Small Vessel Occlusive Stroke and Its Relationship with P300[J].Journal of Medical Information,2019,32(07):66.[doi:10.3969/j.issn.1006-1959.2019.22.021]
[9]王恺知.静脉泵注右美托咪定对颅脑手术患者炎性因子、脑氧代谢及认知功能的影响[J].医学信息,2019,32(23):142.[doi:10.3969/j.issn.1006-1959.2019.23.043]
　WANG Kai-zhi.Effect of Intravenous Dexmedetomidine on Inflammatory Factors,Cerebral Oxygen Metabolism and Cognitive Function in Patients Undergoing Craniocerebral Operation[J].Journal of Medical Information,2019,32(07):142.[doi:10.3969/j.issn.1006-1959.2019.23.043]
[10]郭 青.全麻与腰硬联合麻醉对老年骨科手术患者认知功能及镇痛效果的影响[J].医学信息,2019,32(24):75.[doi:10.3969/j.issn.1006-1959.2019.24.024]
　GUO Qing.Effect of General Anesthesia Combined with Spinal Epidural Anesthesia on Cognitive Function and Analgesic Effect in Elderly Patients Undergoing Orthopedic Surgery[J].Journal of Medical Information,2019,32(07):75.[doi:10.3969/j.issn.1006-1959.2019.24.024]
[11]孙小梅,夏海龙,李丹丹.硼替佐米为基础化疗对多发性骨髓瘤患者认知和情绪的影响[J].医学信息,2022,35(02):136.[doi:10.3969/j.issn.1006-1959.2022.02.034]
　SUN Xiao-mei,XIA Hai-long,LI Dan-dan.Effect of Bortezomib-based Chemotherapy on Cognition and Emotionin Patients with Multiple Myeloma[J].Journal of Medical Information,2022,35(07):136.[doi:10.3969/j.issn.1006-1959.2022.02.034]

更新日期/Last Update: 1900-01-01