[1]陈平兰.布地奈德混悬液联合异丙托溴铵雾化吸入治疗小儿支气管炎临床疗效与安全性研究[J].医学信息,2023,36(08):147-150.[doi:10.3969/j.issn.1006-1959.2023.08.032]
　CHEN Ping-lan.Study on Clinical Efficacy and Safety of Budesonide Suspension Combined with Ipratropium Bromide Aerosol Inhalation in the Treatment of Bronchitis in Children[J].Journal of Medical Information,2023,36(08):147-150.[doi:10.3969/j.issn.1006-1959.2023.08.032]
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布地奈德混悬液联合异丙托溴铵雾化吸入治疗小儿支气管炎临床疗效与安全性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年08期
页码:
147-150
栏目:
论著
出版日期:
2023-04-15

文章信息/Info

Title:
Study on Clinical Efficacy and Safety of Budesonide Suspension Combined with Ipratropium Bromide Aerosol Inhalation in the Treatment of Bronchitis in Children
文章编号:
1006-1959（2023）08-0147-04
作者:
陈平兰
（分宜县人民医院儿科，江西 分宜 336600）
Author(s):
CHEN Ping-lan
(Department of Pediatrics,People’s Hospital of Fenyi County,Fenyi 336600,Jiangxi,China)
关键词:
小儿支气管炎; 布地奈德; 异丙托溴铵; 雾化吸入; 肺功能
Keywords:
Bronchitis in Children; Budesonide; Ipratropium Bromide; Atomization inhalation; Lung function
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2023.08.032
文献标志码:
A
摘要:
目的 探究布地奈德混悬液联合异丙托溴铵雾化吸入治疗小儿支气管炎的临床疗效与安全性。方法 将2021年1月-2022年1月分宜县人民医院收治的62例小儿支气管炎患者纳入本次研究。采用随机数字表法进行分组。对照组（31例）给予异丙托溴铵雾化吸入治疗，观察组（31例）应用布地奈德混悬液联合异丙托溴铵雾化吸入治疗。比较两组临床疗效、症状改善时间（咳嗽消失时间、气促消失时间、退热时间、肺部啰音消失时间）、肺功能[用力肺活量（FVC）、第1 s末用力呼气容积（FEV1）、FEV1占预计值百分比（FEV1%）]、实验室指标[C反应蛋白（CRP）、降钙素原（PCT）]、不良反应。结果 观察组治疗有效率高于对照组（P＜0.05）；观察组咳嗽消失时间、气促消失时间、退热时间、肺部啰音消失时间短于对照组（P＜0.05）；观察组治疗后FVC、FEV1、FEV1%高于对照组，CRP、PCT水平低于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 布地奈德混悬液联合异丙托溴铵雾化吸入治疗小儿支气管炎疗效确切，可加快症状缓解，改善患儿肺功能，下调炎性表达，且不增加不良反应。
Abstract:
Objective To explore the clinical efficacy and safety of budesonide suspension combined with ipratropium bromide aerosol inhalation in the treatment of bronchitis in children.Methods From January 2021 to January 2022,62 children with bronchitis admitted to People’s Hospital of Fenyi County were included in this study. Grouped by random number table method. The control group (31 cases) was treated with ipratropium bromide inhalation, and the observation group (31 cases) was treated with budesonide suspension combined with ipratropium bromide inhalation. The clinical efficacy, symptom improvement time (cough disappearance time, shortness of breath disappearance time, antipyretic time, lung rale disappearance time), lung function [forced vital capacity (FVC), forced expiratory volume at the end of the first second (FEV1), percentage of FEV1 in predicted value (FEV1%)], laboratory indicators [C-reactive protein (CRP), procalcitonin (PCT)] and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). The disappearance time of cough, shortness of breath, fever and lung rale in the observation group were shorter than those in the control group (P<0.05). After treatment, FVC, FEV1 and FEV1% in the observation group were higher than those in the control group, and CRP and PCT levels were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Budesonide suspension combined with ipratropium bromide atomization inhalation is effective in the treatment of children with bronchitis, which can accelerate the relief of symptoms, improve the lung function of children, down-regulate the expression of inflammation, and do not increase adverse reactions.

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更新日期/Last Update: 1900-01-01