[1]廖锋生.硫酸羟氯喹治疗类风湿性关节炎的疗效及对患者炎症因子、自身抗体水平的影响[J].医学信息,2023,36(08):151-154.[doi:10.3969/j.issn.1006-1959.2023.08.033]
　LIAO Feng-sheng.Efficacy of Hydroxychloroquine Sulfate in the Treatment of Rheumatoid Arthritis and its Effect on the Levels of Inflammatory Factors and Autoantibodies[J].Journal of Medical Information,2023,36(08):151-154.[doi:10.3969/j.issn.1006-1959.2023.08.033]
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硫酸羟氯喹治疗类风湿性关节炎的疗效及对患者炎症因子、自身抗体水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年08期
页码:
151-154
栏目:
论著
出版日期:
2023-04-15

文章信息/Info

Title:
Efficacy of Hydroxychloroquine Sulfate in the Treatment of Rheumatoid Arthritis and its Effect on the Levels of Inflammatory Factors and Autoantibodies
文章编号:
1006-1959（2023）08-0151-04
作者:
廖锋生
（遂川县人民医院中医康复科，江西 遂川 343900）
Author(s):
LIAO Feng-sheng
(Rehabilitation Department of Traditional Chinese Medicine,Suichuan People’s Hospital,Suichuan 343900,Jiangxi,China)
关键词:
类风湿性关节炎; 硫酸羟氯喹; 甲氨蝶呤; 炎症因子; 自身抗体
Keywords:
Rheumatoid arthritis; Hydroxychloroquine sulfate; Methotrexate; Inflammatory factors; Autoantibodies
分类号:
R593.22
DOI:
10.3969/j.issn.1006-1959.2023.08.033
文献标志码:
A
摘要:
目的 研究硫酸羟氯喹治疗类风湿性关节炎（RA）的临床疗效及对患者炎症因子、自身抗体水平的影响。方法 选取2018年10月-2020年10月遂川县人民医院收治的60例RA患者，按照随机数字表法分为对照组（30例）与观察组（30例），对照组应用甲氨蝶呤治疗，观察组在其基础上联合硫酸羟氯喹治疗，比较两组临床疗效、症状改善情况（关节疼痛程度、晨僵时间、压痛关节数目、肿胀关节数目）、肌骨超声表现（软骨厚度、积液厚度、滑膜厚度及超声评分）、炎症因子[红细胞沉降率（ESR）、C-反应蛋白（CRP）]、自身抗体[类风湿因子（RF）、抗环瓜氨酸肽（CCP）抗体]及不良反应发生情况。结果 观察组总有效率高于对照组（P＜0.05）；观察组关节疼痛程度小于对照组，晨僵时间及压痛、肿胀关节数目少于对照组（P＜0.05）；观察组软骨厚度大于对照组，积液厚度、滑膜厚度、超声评分低于对照组（P＜0.05）；观察组ESR、CRP、RF、抗CCP抗体水平低于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 硫酸羟氯喹治疗RA疗效肯定，可改善患者机体症状及肌骨超声表现，缓解炎症反应，降低患者自身抗体水平，且不增加不良反应，安全性良好。
Abstract:
Objective To study the clinical efficacy of hydroxychloroquine sulfate in the treatment of rheumatoid arthritis (RA) and its effect on the levels of inflammatory factors and autoantibodies.Methods Sixty patients with RA admitted to Suichuan County People’s Hospital from October 2018 to October 2020 were selected and divided into control group (30 cases) and observation group (30 cases) according to the random number table method. The control group was treated with methotrexate, and the observation group was treated with hydroxychloroquine sulfate on the basis of methotrexate. The clinical efficacy, symptom improvement (joint pain degree, morning stiffness time, number of tender joints, number of swollen joints), musculoskeletal ultrasound performance (cartilage thickness, effusion thickness, synovial thickness and ultrasound score), inflammatory factors [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)], autoantibodies [rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody] and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The degree of joint pain in the observation group was less than that in the control group, and the time of morning stiffness and the number of tender and swollen joints were less than those in the control group (P<0.05). The cartilage thickness of the observation group was greater than that of the control group, and the thickness of effusion, synovial thickness and ultrasound score were lower than those of the control group (P<0.05). The levels of ESR, CRP, RF and anti-CCP antibody in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Hydroxychloroquine sulfate is effective in the treatment of RA, which can improve the body symptoms and musculoskeletal ultrasound manifestations of patients, alleviate the inflammatory response, reduce the level of autoantibodies, and do not increase adverse reactions, with good safety.

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更新日期/Last Update: 1900-01-01