[1]黄 倩,李 涛,谢 艳,等.阿巴西普治疗抗环瓜氨酸肽抗体阳性类风湿关节炎的临床研究进展[J].医学信息,2023,36(09):168-173.[doi:10.3969/j.issn.1006-1959.2023.09.037]
 HUANG Qian,LI Tao,XIE Yan,et al.Clinical Research Progress of Abatacept in the Treatment of Anti-cyclic Citrullinated Peptide Antibody Positive Rheumatoid Arthritis[J].Journal of Medical Information,2023,36(09):168-173.[doi:10.3969/j.issn.1006-1959.2023.09.037]
点击复制

阿巴西普治疗抗环瓜氨酸肽抗体阳性类风湿关节炎的临床研究进展()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年09期
页码:
168-173
栏目:
综述
出版日期:
2023-05-01

文章信息/Info

Title:
Clinical Research Progress of Abatacept in the Treatment of Anti-cyclic Citrullinated Peptide Antibody Positive Rheumatoid Arthritis
文章编号:
1006-1959(2023)09-0168-06
作者:
黄 倩李 涛谢 艳
(川北医学院附属医院老年科1,风湿免疫科2,四川 南充 637000)
Author(s):
HUANG QianLI TaoXIE Yanet al.
(Department of Geriatrics1,Department of Rheumatology and Immunology2,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
关键词:
类风湿关节炎抗环瓜氨酸肽抗体T细胞
Keywords:
Rheumatoid arthritisAnti-cyclic citrullinated peptide antibodyT cell
分类号:
R593.22
DOI:
10.3969/j.issn.1006-1959.2023.09.037
文献标志码:
A
摘要:
类风湿性关节炎(RA),一种以慢性关节炎症和持续性滑膜细胞浸润为特征的自身免疫性疾病,研究表明抗环瓜氨酸肽抗体(ACPA)阳性RA患者的预后更差。阿巴西普是一种通过阻断T细胞激活的生物类抗风湿药物(bDMARD),相较于ACPA阴性患者,对ACPA阳性患者有着更好的缓解作用,其作用机制及其在ACPA阳性患者中的临床疗效与安全性也备受关注。本文通过对阿巴西普作用机制及其对ACPA阳性患者的疗效和安全性进行综述,以期为临床治疗该病以及未来更进一步的研究提供参考。
Abstract:
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic joint inflammation and persistent synovial cell infiltration. Studies have shown that anti-cyclic citrullinated peptide antibody (ACPA) positive RA patients have a worse prognosis. Abbasip is a biological disease modifying antirheumatic drugs (bDMARD) that blocks T cell activation. Compared with ACPA negative patients, it has a better remission effect on ACPA positive patients. Its mechanism of action and its clinical efficacy and safety in ACPA positive patients have also attracted much attention. This article reviews the mechanism of abasip and its efficacy and safety in ACPA-positive patients, in order to provide reference for clinical treatment and further research in the future.

参考文献/References:

[1]Lee DM,Weinblatt ME.Rheumatoid arthritis[J].Lancet,2001,358(9285):903-911.[2]Hernández-Breijo B,Plasencia-Rodríguez C,Navarro-Compán V,et al.Remission Induced by TNF Inhibitors Plus Methotrexate is Associated With Changes in Peripheral Naive B Cells in Patients With Rheumatoid Arthritis[J].ront Med (Lausanne),2021,8:683990.[3]Tono T,Aihara S,Hoshiyama T,et al.Effects of CTLA4-Ig on human monocytes[J].Inflamm Regen,2017,37:24.[4]van der Helm-van Mil AH,Verpoort KN,Breedveld FC,et al.Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis[J].Arthritis Res Ther,2005,7(5):R949-R958.[5]Riedemann JP,Mu?oz S,Kavanaugh A.The use of second generation anti-CCP antibody (anti-CCP2) testing in rheumatoid arthritis--a systematic review[J].Clin Exp Rheumatol,2005,23(5 Suppl 39):S69-S76.[6]Wu X,Liu Y,Jin S,et al.Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis[J].Nat Commun,2021,12(1):4977.[7]McInnes IB,Schett G.Pathogenetic insights from the treatment of rheumatoid arthritis[J].Lancet,2017,389(10086):2328-2337.[8]Pratt AG,Isaacs JD.Seronegative rheumatoid arthritis: pathogenetic and therapeutic aspects[J].Best Pract Res Clin Rheumatol,2014,28(4):651-659.[9]Niewold TB,Harrison MJ,Paget SA.Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis[J].QJM,2007,100(4):193-201.[10]Hecht C,Englbrecht M,Rech J,et al.Additive effect of anti-citrullinated protein antibodies and rheumatoid factor on bone erosions in patients with RA[J].Ann Rheum Dis,2015,74(12):2151-2156.[11]Lin Q,Zhou B,Song X,et al.Genetic variant in SPAG16 is associated with the susceptibility of ACPA-positive rheumatoid arthritis possibly via regulation of MMP-3[J].J Orthop Surg Res,2022,17(1):511.[12]Ajeganova S,Humphreys JH,Verheul MK,et al.Anticitrullinated protein antibodies and rheumatoid factor are associated with increased mortality but with different causes of death in patients with rheumatoid arthritis: a longitudinal study in three European cohorts[J].Ann Rheum Dis,2016,75(11):1924-1932.[13]Smolen JS,Landewé RBM,Bijlsma JWJ,et al.EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update[J].Ann Rheum Dis,2020,79(6):685-699.[14]Hosseini A,Gharibi T,Marofi F,et al.CTLA-4: From mechanism to autoimmune therapy[J].Int Immunopharmacol,2020,80:106221.[15]Moreland L,Bate G,Kirkpatrick P.Abatacept[J].Nat Rev Drug Discov,2006,5(3):185-186.[16]Kremer JM,Westhovens R,Leon M,et al.Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig[J].N Engl J Med,2003,349(20):1907-1915.[17]Pieper J,Herrath J,Raghavan S,et al.CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients[J].BMC Immunology,2013,14(1):34.[18]Bonelli M,Ferner E,G?觟schl L,et al.Abatacept (CTLA-4IG) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis[J].Arthritis Rheum,2013,65(3):599-607.[19]Emery P,Deodhar A,Rigby WF,et al.Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab’s Efficacy in MTX iNadequate rEsponders (SERENE))[J].Ann Rheum Dis,2010,69(9):1629-1635.[20]Platt AM,Gibson VB,Patakas A,et al.Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells[J].J Immunol,2010,185(3):1558-1567.[21]Matsubara T,Inoue H,Nakajima T,et al.Abatacept in combination with methotrexate in Japanese biologic-naive patients with active rheumatoid arthritis: a randomised placebo-controlled phase IV study[J].RMD Open,2018,4(2):e000813.[22]Jansen DTSL,Emery P,Smolen JS,et al.Conversion to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained remission: post hoc analysis of the AGREE study[J].RMD Open,2018,4(1):e000564.[23]Alten R,Burkhardt H,Feist E,et al.Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs:a descriptive analysis of data from interventional trials and the real-world setting[J].Arthritis Res Ther,2018,20(1):1.[24]Weinblatt ME,Schiff M,Valente R,et al.Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: findings of a phase IIIb, multinational, prospective, randomized study[J].Arthritis Rheum,2013,65(1):28-38.[25]Genovese MC,Schiff M,Luggen M,et al.Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy[J].Ann Rheum Dis,2008,67(4):547-554.[26]Harrold LR,Litman HJ,Connolly SE,et al.Comparative Effectiveness of Abatacept Versus Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis Who Are Anti-CCP Positive in the United States Corrona Registry[J].Rheumatol Ther,2019,6(2):217-230.[27]Westhovens R,Connolly SE,Margaux J,et al.Up to 5-year retention of abatacept in Belgian patients with moderate-to-severe rheumatoid arthritis: a sub-analysis of the international, observational ACTION study[J].Rheumatol Int,2020,40(9):1409-1421.[28]Elmedany SH,Mohamed AE,Galil SMA.Efficacy and safety profile of intravenous tocilizumab versus intravenous abatacept in treating female Saudi Arabian patients with active moderate-to-severe rheumatoid arthritis[J].Clin Rheumatol,2019,38(8):2109-2117.[29]Schiff M,Keiserman M,Codding C,et al.Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate[J].Ann Rheum Dis,2008,67(8):1096-1103.[30]Smitten AL,Choi HK,Hochberg MC,et al.The risk of hospitalized infection in patients with rheumatoid arthritis[J].J Rheumatol,2008,35(3):387-393.[31]Simon TA,Thompson A,Gandhi KK,et al.Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis[J].Arthritis Res Ther,2015,17(1):212.[32]Kremers HM,Crowson CS,Therneau TM,et al.High ten-year risk of cardiovascular disease in newly diagnosed rheumatoid arthritis patients: a population-based cohort study[J].Arthritis Rheum,2008,58(8):2268-2274.[33]Totoson P,Maguin-Gaté K,Prati C,et al.Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies[J].Arthritis Res Ther,2014,16(1):202.[34]Benucci M,Bandinelli F,Damiani A,et al.Factors correlated with the improvement of endothelial dysfunction during Abatacept therapy in patients with rheumatoid arthritis[J].J Inflamm Res,2018,11:247-252.[35]Wadstr?觟m H,Frisell T,Askling J.Anti-Rheumatic Therapy in Sweden (ARTIS) Study Group. Malignant Neoplasms in Patients With Rheumatoid Arthritis Treated With Tumor Necrosis Factor Inhibitors, Tocilizumab, Abatacept, or Rituximab in Clinical Practice: A Nationwide Cohort Study From Sweden[J].JAMA Intern Med,2017,177(11):1605-1612.[36]Simon TA,Boers M,Hochberg M,et al.Comparative risk of malignancies and infections in patients with rheumatoid arthritis initiating abatacept versus other biologics: a multi-database real-world study[J].Arthritis Res Ther,2019,21(1):228.[37]Kremer JM,Genant HK,Moreland LW,et al.Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate[J].Arthritis Rheum,2008,58(4):953-963.[38]Cabral VP,Andrade CA,Passos SR,et al.Severe infection in patients with rheumatoid arthritis taking anakinra, rituximab, or abatacept: a systematic review of observational studies[J].Rev Bras Reumatol Engl Ed,2016,56(6):543-550.[39]Ozen G,Pedro S,Schumacher R,et al.Safety of abatacept compared with other biologic and conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: data from an observational study[J].Arthritis Res Ther,2019,21(1):141.[40]Petro AD,Dougherty J,England BR,et al.Associations between an expanded autoantibody profile and treatment responses to biologic therapies in patients with rheumatoid arthritis[J].Int Immunopharmacol,2021,91:107260.[41]Alemao E,Postema R,Elbez Y,et al.Presence of anti-cyclic citrullinated peptide antibodies is associated with better treatment response to abatacept but not to TNF inhibitors in patients with rheumatoid arthritis: a meta-analysis[J].Clin Exp Rheumatol,2020,38(3):455-466.[42]Alten R,Nüβlein HG,Mariette X,et al.Baseline autoantibodies preferentially impact abatacept efficacy in patients with rheumatoid arthritis who are biologic na?ve: 6-month results from a real-world, international, prospective study[J].RMD Open,2017,3(1):e000345.[43]Sokolove J,Schiff M,Fleischmann R,et al.Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab:2-year results from the AMPLE trial[J].Ann Rheum Dis,2016,75(4):709-714.[44]Scott DL,Pugner K,Kaarela K,et al.The links between joint damage and disability in rheumatoid arthritis[J].Rheumatology (Oxford),2000,39(2):122-132.[45]Kremer JM,Peterfy C,Russell AS,et al.Longterm safety, efficacy, and inhibition of structural damage progression over 5 years of treatment with abatacept in patients with rheumatoid arthritis in the abatacept in inadequate responders to methotrexate trial[J].J Rheumatol,2014,41(6):1077-1087.[46]Kremer JM,Genant HK,Moreland LW,et al.Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial[J].Ann Intern Med,2006,144(12):865-876.[47]Endo Y,Koga T,Kawashiri SY,et al.Anti-citrullinated protein antibody titre as a predictor of abatacept treatment persistence in patients with rheumatoid arthritis: a prospective cohort study in Japan[J].Scand J Rheumatol,2020,49(1):13-17.

相似文献/References:

[1]章 豫,艾艳红.蛋白质代谢变化、血脂与类风湿关节炎患者动脉粥样硬化的相关性研究[J].医学信息,2018,31(02):84.[doi:10.3969/j.issn.1006-1959.2018.02.028]
 ZHANG Yu,AI Yan-hong.Correlation between Changes of Protein Metabolism,Serum Lipids and Atherosclerosis in Patients with Rheumatoid Arthritis[J].Journal of Medical Information,2018,31(09):84.[doi:10.3969/j.issn.1006-1959.2018.02.028]
[2]黄 娟,叶福银.类风湿关节炎合并腹痛1例[J].医学信息,2018,31(08):188.[doi:10.3969/j.issn.1006-1959.2018.08.070]
[3]杜 敏,李 娜.抗CCP抗体与RF联合检测在类风湿关节炎早期诊断中的意义[J].医学信息,2019,32(06):177.[doi:10.3969/j.issn.1006-1959.2019.06.058]
 DU Min,LI Na.Significance of Combined Detection of Anti-CCP Antibody and RF in Early Diagnosis of Rheumatoid Arthritis[J].Journal of Medical Information,2019,32(09):177.[doi:10.3969/j.issn.1006-1959.2019.06.058]
[4]万 昭,向 阳.中药延缓类风湿关节炎骨破坏的研究进展[J].医学信息,2019,32(07):36.[doi:10.3969/j.issn.1006-1959.2019.07.013]
 WAN Zhao,XIANG Yang.Research Progress on Traditional Chinese Medicine for Delaying Bone Destruction of Rheumatoid Arthritis[J].Journal of Medical Information,2019,32(09):36.[doi:10.3969/j.issn.1006-1959.2019.07.013]
[5]杨海红,星 霞,李雪莹,等.类风湿关节炎患者焦虑及抑郁情绪与 疾病活动度的相关性[J].医学信息,2019,32(18):110.[doi:10.3969/j.issn.1006-1959.2019.18.036]
 YANG Hai-hong,XING Xia,LI Xue-ying,et al.Correlation between Anxiety and Depression and Disease Activity in Patients with Rheumatoid Arthritis[J].Journal of Medical Information,2019,32(09):110.[doi:10.3969/j.issn.1006-1959.2019.18.036]
[6]郑 伟.诱骗受体3γ-干扰素和抗环瓜氨酸肽抗体在风湿性关节炎患者血清中的表达[J].医学信息,2019,32(19):97.[doi:10.3969/j.issn.1006-1959.2019.19.029]
 ZHENG Wei.Expression of Decoy Receptor 3γ-Interferon and Anti-Cyclic Citrullinated Peptide Antibody in Serum of Patients with Rheumatoid Arthritis[J].Journal of Medical Information,2019,32(09):97.[doi:10.3969/j.issn.1006-1959.2019.19.029]
[7]王 鹏,郝敬春,厉志洪,等.超微血管成像技术评估类风湿关节炎手指关节 亚临床炎及分布特点[J].医学信息,2019,32(14):98.[doi:10.3969/j.issn.1006-1959.2019.14.030]
 WANG Peng,HAO Jing-chun,LI Zhi-hong,et al.Evaluation of Subclinical Inflammation and Distribution of Finger Joints in Rheumatoid Arthritis by Ultra-Microvascular Imaging[J].Journal of Medical Information,2019,32(09):98.[doi:10.3969/j.issn.1006-1959.2019.14.030]
[8]丁宇康.化瘀通痹方联合甲氨蝶呤治疗难治性类风湿关节炎的效果[J].医学信息,2019,32(24):171.[doi:10.3969/j.issn.1006-1959.2019.24.063]
 DING Yu-kang.Observation of Huayu Tongbi Recipe Combined with Methotrexate in the Treatment of Refractory Rheumatoid Arthritis[J].Journal of Medical Information,2019,32(09):171.[doi:10.3969/j.issn.1006-1959.2019.24.063]
[9]陈 婧,高晓瑜.类风湿关节炎多关节病变的超声诊断[J].医学信息,2020,33(16):175.[doi:10.3969/j.issn.1006-1959.2020.16.058]
 CHEN Jing,GAO Xiao-Yu.Ultrasonic Diagnosis of Rheumatoid Arthritis Polyarthropathy[J].Journal of Medical Information,2020,33(09):175.[doi:10.3969/j.issn.1006-1959.2020.16.058]
[10]王宝娟,辛昊洋,李 月.基于网络药理学探讨木防己汤治疗类风湿关节炎的作用机制[J].医学信息,2022,35(23):25.[doi:10.3969/j.issn.1006-1959.2022.23.005]
 WANG Bao-juan,XIN Hao-yang,LI Yue.Study on Mechanism of Mufangji Decoction in the Treatment of Rheumatoid Arthritis Based on Network Pharmacology[J].Journal of Medical Information,2022,35(09):25.[doi:10.3969/j.issn.1006-1959.2022.23.005]

更新日期/Last Update: 1900-01-01