[1]张 皓.阿司匹林联合奥扎格雷双抗血小板治疗脑梗死的疗效及对患者血清hs-CRP及D-D水平的影响[J].医学信息,2023,36(13):123-126.[doi:10.3969/j.issn.1006-1959.2023.13.025]
　ZHANG Hao.Effect of Aspirin Combined with Ozagrel Dual Antiplatelet Therapy on Cerebral Infarction and its Effect on Serum hs-CRP and D-D Levels in Patients with Cerebral Infarction[J].Journal of Medical Information,2023,36(13):123-126.[doi:10.3969/j.issn.1006-1959.2023.13.025]
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阿司匹林联合奥扎格雷双抗血小板治疗脑梗死的疗效及对患者血清hs-CRP及D-D水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年13期
页码:
123-126
栏目:
论著
出版日期:
2023-07-01

文章信息/Info

Title:
Effect of Aspirin Combined with Ozagrel Dual Antiplatelet Therapy on Cerebral Infarction and its Effect on Serum hs-CRP and D-D Levels in Patients with Cerebral Infarction
文章编号:
1006-1959（2023）13-0123-04
作者:
张 皓
（佳木斯大学附属第一医院内科，黑龙江 佳木斯 154003）
Author(s):
ZHANG Hao
(Internal Medicine Department of the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,Heilongjiang,China)
关键词:
脑梗死; 阿司匹林; 奥扎格雷; 抗血小板治疗; 超敏C反应蛋白; D-二聚体
Keywords:
Cerebral infarction; Aspirin; Ozagre; Antiplatelet therapy; Hyper-sensitivity C-reactive protein; D-dimer
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2023.13.025
文献标志码:
A
摘要:
目的 探究阿司匹林联合奥扎格雷双抗血小板治疗脑梗死（CI）的临床疗效及对患者血清超敏C反应蛋白（hs-CRP）及D-二聚体（D-D）水平的影响。方法 选取2020年6月-2022年6月佳木斯大学附属第一医院收治的60例CI患者，经随机数字表法分为对照组与观察组，各30例。对照组给予阿司匹林血小板治疗，观察组则应用阿司匹林联合奥扎格雷双抗血小板治疗，比较两组临床疗效、血小板参数[血小板计数（PLT）、平均血小板体积（MPV）]、血清超敏C反应蛋白（hs-CRP）、D-二聚体（D-D）、美国国立卫生研究院卒中量表（NIHSS）评分、改良Barthel指数（MBI）评分及不良反应。结果 观察组治疗总有效率较对照组高（P＜0.05）；两组治疗后MPV、hs-CRP、D-D水平低于治疗前，且观察组MPV、hs-CRP、D-D水平低于对照组（P＜0.05）；两组治疗后 NIHSS评分低于治疗前，MBI评分高于治疗前，且观察组NIHSS评分低于对照组，MBI评分高于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 阿司匹林联合奥扎格雷双抗血小板治疗CI疗效肯定，可有效抑制血小板活化，改善机体炎性及高凝状态，下调血清hs-CRP、D-D水平，促使神经功能恢复，提高患者的独立生活能力，且不增加药物不良反应，安全性良好。
Abstract:
Objective To investigate the clinical efficacy of aspirin combined with ozagrel dual antiplatelet therapy in the treatment of cerebral infarction (CI) and its effect on serum high-sensitivity C-reactive protein (hs-CRP) and D-dimer (D-D) levels.Methods Sixty patients with CI admitted to the First Affiliated Hospital of Jiamusi University from June 2020 to June 2022 were selected and divided into control group and observation group by random number table method, with 30 cases in each group. The control group was treated with aspirin platelet therapy, while the observation group was treated with aspirin combined with ozagrel dual antiplatelet therapy. The clinical efficacy, platelet parameters [platelet count (PLT), mean platelet volume (MPV)], serum high-sensitivity C-reactive protein (hs-CRP), D-dimer (D-D), National Institutes of Health Stroke Scale (NIHSS) score, modified Barthel index (MBI) score and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group (P<0.05). The levels of MPV, hs-CRP and D-D in the two groups after treatment were lower than those before treatment, and the levels of MPV,hs-CRP and D-D in the observation group were lower than those in the control group (P<0.05). After treatment, the NIHSS score of the two groups was lower than that before treatment, and the MBI score was higher than that before treatment, while the NIHSS score of the observation group was lower than that of the control group, and the MBI score was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Aspirin combined with ozagrel dual antiplatelet therapy is effective in the treatment of CI, which can effectively inhibit platelet activation, improve the body’s inflammatory and hypercoagulable state, down-regulate serum hs-CRP and D-D levels, promote the recovery of neurological function, and improve the patient’s independent living ability. Meanwhile, it does not increase adverse drug reactions and has good safety.

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更新日期/Last Update: 1900-01-01