[1]郑国盛.多巴胺联合硝普钠治疗急性心力衰竭伴低血压的临床效果及对心功能和预后的影响[J].医学信息,2023,36(14):137-140.[doi:10.3969/j.issn.1006-1959.2023.14.028]
　ZHENG Guo-sheng.Clinical Effect of Dopamine Combined with Sodium Nitroprusside in the Treatment of Acute Heart Failure with Hypotension and its Effect on Cardiac Function and Prognosis[J].Journal of Medical Information,2023,36(14):137-140.[doi:10.3969/j.issn.1006-1959.2023.14.028]
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多巴胺联合硝普钠治疗急性心力衰竭伴低血压的临床效果及对心功能和预后的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年14期
页码:
137-140
栏目:
论著
出版日期:
2023-07-15

文章信息/Info

Title:
Clinical Effect of Dopamine Combined with Sodium Nitroprusside in the Treatment of Acute Heart Failure with Hypotension and its Effect on Cardiac Function and Prognosis
文章编号:
1006-1959（2023）14-0137-04
作者:
郑国盛
（金溪县中医院内科，江西 金溪 344800）
Author(s):
ZHENG Guo-sheng
(Department of Internal Medicine,Jinxi County Hospital of Traditional Chinese Medicine,Jinxi 344800,Jiangxi,China)
关键词:
多巴胺; 硝普钠; 急性心力衰竭; 低血压; 心功能
Keywords:
Dopamine; Nitroprusside; Acute heart failure; Hypotension; Cardiac function
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2023.14.028
文献标志码:
A
摘要:
目的 观察多巴胺联合硝普钠治疗急性心力衰竭伴低血压临床效果及对心功能和预后的影响。方法 选取2020年1月-2022年1月我院诊治的65例急性心力衰竭伴低血压患者为研究对象，采用随机数字表法分为对照组（n=33）和观察组（n=32），对照组采用硝普钠治疗，观察组在对照组基础上联合应用多巴胺治疗，比较两组临床疗效、血压水平（收缩压、舒张压）、心功能指标[心率、左心室射血分数（LVEF）、左心室舒张末内径（LVEDD）、N末端B型钠尿肽前体（NT-proBNP）]、不良反应发生率。结果 观察组治疗总有效率为93.75%，高于对照组的81.82%（P＜0.05）；两组治疗后收缩压、舒张压高于治疗前，且观察组高于对照组（P＜0.05）；两组治疗后心率、LVEDD、NT-proBNP均低于治疗前，LVEF高于治疗前，且观察组心率、LVEDD、NT-proBNP均低于对照组，LVEF高于对照组（P＜0.05）；观察组不良反应发生率为9.38%，与对照组的9.09%比较，差异无统计学意义（P＞0.05）。结论 多巴胺联合硝普钠治疗急性心力衰竭伴低血压可提高治疗疗效，改善血压水平、心功能指标，促进患者预后改善，且不会增加临床不良反应，是一种可行的联合用药治疗方案。
Abstract:
Objective To observe the clinical effect of dopamine combined with sodium nitroprusside in the treatment of acute heart failure with hypotension and its effect on cardiac function and prognosis.Methods A total of 65 patients with acute heart failure and hypotension diagnosed and treated in our hospital from January 2020 to January 2022 were selected as the research objects. They were divided into control group (n=33) and observation group (n=32) by random number table method. The control group was treated with sodium nitroprusside, and the observation group was treated with dopamine on the basis of the control group. The clinical efficacy, blood pressure level (systolic blood pressure, diastolic blood pressure), cardiac function indexes [heart rate, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), N-terminal B-type natriuretic peptide precursor (NT-proBNP)] and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.75%, which was higher than 81.82% in the control group (P<0.05). The systolic blood pressure and diastolic blood pressure of the two groups after treatment were higher than those before treatment, and the observation group was higher than the control group (P<0.05). After treatment, the heart rate, LVEDD and NT-proBNP in the two groups were lower than those before treatment, LVEF was higher than that before treatment, and the heart rate, while LVEDD and NT-proBNP in the observation group were lower than those in the control group, LVEF was higher than that in the control group (P<0.05). The incidence of adverse reactions in the observation group was 9.38%, which was compared with 9.09% in the control group, the difference was not statistically significant (P>0.05).Conclusion Dopamine combined with sodium nitroprusside in the treatment of acute heart failure with hypotension can improve the therapeutic effect, improve blood pressure level and cardiac function index, promote the prognosis of patients, and will not increase clinical adverse reactions. It is a feasible combination therapy.

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更新日期/Last Update: 1900-01-01