[1]许 婷,李媛媛.血清HBV-DNA联合免疫球蛋白检测对慢性乙型肝炎诊断的临床价值[J].医学信息,2023,36(22):156-159.[doi:10.3969/j.issn.1006-1959.2023.22.036]
　XU Ting,LI Yuan-yuan.Clinical Value of Serum HBV-DNA Combined with Immunoglobulin Detection in the Diagnosis of Chronic Hepatitis B[J].Journal of Medical Information,2023,36(22):156-159.[doi:10.3969/j.issn.1006-1959.2023.22.036]
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血清HBV-DNA联合免疫球蛋白检测对慢性乙型肝炎诊断的临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年22期
页码:
156-159
栏目:
诊疗技术
出版日期:
2023-11-15

文章信息/Info

Title:
Clinical Value of Serum HBV-DNA Combined with Immunoglobulin Detection in the Diagnosis of Chronic Hepatitis B
文章编号:
1006-1959（2023）22-0156-04
作者:
许 婷; 李媛媛
（宜春市中医院检验科，江西 宜春 336000）
Author(s):
XU Ting; LI Yuan-yuan
(Department of Laboratory,Yichun City Hospital of Traditional Chinese Medicine,Yichun 336000,Jiangxi,China)
关键词:
慢性乙型肝炎; HBV-DNA; 免疫球蛋白; 联合检测; 阳性检出率; 病情分级
Keywords:
Chronic hepatitis B; HBV-DNA; Immunoglobulin; Combined detection; Positive detection rate; Disease grading
分类号:
R512.6+2；R446.6
DOI:
10.3969/j.issn.1006-1959.2023.22.036
文献标志码:
A
摘要:
目的 探究血清乙肝病毒-脱氧核糖核酸（HBV-DNA）联合免疫球蛋白检测对慢性乙型肝炎的诊断价值。方法 以2022年3月-2023年3月宜春市中医院收治的70例慢性乙肝患者为研究对象设为乙肝组，另取70例同期体检健康者设为健康组，对两组血清HBV-DNA与免疫球蛋白指标（IgG、IgA、IgM）进行检测，比较其检测结果，统计血清HBV-DNA与免疫球蛋白检测对乙肝的阳性检出率，分析不同病情程度患者的血清HBV-DNA与免疫球蛋白水平。结果 乙肝组血清HBV-DNA与免疫球蛋白（IgG、IgA、IgM）水平均高于健康组（P＜0.05）；血清HBV-DNA与免疫球蛋白联合检测的乙肝阳性检出率高于其单独检测（P＜0.05）；不同病情分级患者的血清HBV-DNA与免疫球蛋白水平比较，差异有统计学意义（P＜0.05），其血清HBV-DNA与免疫球蛋白水平由高至低依次为重度＞中度＞轻度。结论 血清HBV-DNA与免疫球蛋白检测在慢性乙肝诊断中具有确切应用价值，二者联合检测可提高乙肝阳性检出率，对其病情严重程度具有一定评估作用。
Abstract:
Objective To explore the diagnostic value of serum hepatitis B virus-deoxyribonucleic acid (HBV-DNA) combined with immunoglobulin detection in chronic hepatitis B.Methods A total of 70 patients with chronic hepatitis B admitted to Yichun Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were selected as the hepatitis B group, and 70 healthy people who underwent physical examination during the same period were selected as the healthy group. The serum HBV-DNA and immunoglobulin indexes (IgG, IgA, IgM) of the two groups were detected, and the detection results were compared. The positive detection rate of serum HBV-DNA and immunoglobulin detection for hepatitis B was counted, and the serum HBV-DNA and immunoglobulin levels of patients with different degrees of illness were analyzed.Results The levels of serum HBV-DNA and immunoglobulin (IgG, IgA, IgM) in hepatitis B group were higher than those in healthy group (P<0.05). The positive rate of hepatitis B detected by combined detection of serum HBV-DNA and immunoglobulin was higher than that detected alone (P<0.05). There were statistically significant differences in serum HBV-DNA and immunoglobulin levels among patients with different disease grades (P<0.05). The levels of serum HBV-DNA and immunoglobulin from high to low were severe＞moderate＞mild.Conclusion The detection of serum HBV-DNA and immunoglobulin has definite application value in the diagnosis of chronic hepatitis B. The combined detection of the two can improve the positive detection rate of hepatitis B and has a certain evaluation effect on the severity of the disease.

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更新日期/Last Update: 1900-01-01