[1]吴 培,陈 竹,李灵芝,等.槐杞黄颗粒联合醋酸泼尼松治疗儿童原发性肾病综合征的效果及对凝血功能、免疫功能的影响[J].医学信息,2024,37(01):154-157.[doi:10.3969/j.issn.1006-1959.2024.01.027]
　WU Pei,CHEN Zhu,LI Ling-zhi,et al.Effect of Huaiqihuang Granules Combined with Prednisone Acetate in the Treatment of Children with Primary Nephrotic Syndrome and its Influence on Coagulation Function and Immune Function[J].Journal of Medical Information,2024,37(01):154-157.[doi:10.3969/j.issn.1006-1959.2024.01.027]
点击复制

槐杞黄颗粒联合醋酸泼尼松治疗儿童原发性肾病综合征的效果及对凝血功能、免疫功能的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年01期
页码:
154-157
栏目:
论著
出版日期:
2024-01-01

文章信息/Info

Title:
Effect of Huaiqihuang Granules Combined with Prednisone Acetate in the Treatment of Children with Primary Nephrotic Syndrome and its Influence on Coagulation Function and Immune Function
文章编号:
1006-1959（2024）01-0154-04
作者:
吴 培; 陈 竹; 李灵芝; 等
（电子科技大学医学院附属绵阳医院/绵阳市中心医院儿科，四川 绵阳 621000）
Author(s):
WU Pei; CHEN Zhu; LI Ling-zhi; et al.
(Department of Pediatrics,Mianyang Hospital Affiliated to School of Medicine University of Electronic Scienceand Technology of China/Mianyang Central Hospital,Mianyang 621000,Sichuan,China)
关键词:
肾病综合征; 槐杞黄颗粒; 凝血功能; 免疫功能
Keywords:
Primary nephrotic syndrome; Huaiqihuang granules; Coagulation function; Immune function
分类号:
R752.51
DOI:
10.3969/j.issn.1006-1959.2024.01.027
文献标志码:
A
摘要:
目的 探究槐杞黄颗粒联合醋酸泼尼松治疗原发性肾病综合征（PNS）的效果及对凝血功能、免疫功能的影响。方法 将我院2020年4月-2022年4月收治的47例住院期间确诊为PNS患儿随机分为观察组（n=24）和对照组（n=23）。对照组仅予以醋酸泼尼松治疗，观察组予以醋酸泼尼松联合槐杞黄颗粒治疗，比较两组治疗4周后尿蛋白/尿肌酐比值、血小板、血总胆固醇、血白蛋白、凝血功能（纤维蛋白原、D-二聚体、抗凝血酶Ⅲ）、免疫球蛋白（IgA、IgM、IgG）、淋巴细胞亚群计数指标（CD3+、CD3+CD4+、CD4+/CD8+）及不良反应发生情况。结果 两组治疗后白蛋白、IgG高于治疗前，且观察组高于对照组（P＜0.05）；两组治疗后血小板、尿蛋白/尿肌酐比值、纤维蛋白原低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后总胆固醇、D-二聚体、抗凝血酶原Ⅲ、IgA、IgM、CD3+、CD3+CD4+、CD4+/CD8+水平比较，差异无统计学意义（P＞0.05）。结论 槐杞黄颗粒联合醋酸泼尼松治疗能够在较短时间内降低PNS患儿尿蛋白水平，提升白蛋白，维持免疫球蛋白IgG正常水平，改善血小板和纤维蛋白原，从而改善患儿高凝状态，且安全性较高。
Abstract:
Objective To explore the effect of Huaiqihuang granules combined with prednisone acetate in the treatment of primary nephrotic syndrome (PNS) and its influence on coagulation function and immune function.Methods From April 2020 to April 2022, 47 children diagnosed with PNS during hospitalization in our hospital were randomly divided into observation group (n=24) and control group (n=23). The control group was treated with prednisone acetate alone, The observation group was treated with prednisone acetate combined with Huaiqihuang granules. The urinary protein/urinary creatinine ratio, platelet, total cholesterol, albumin, coagulation function (fibrinogen, D-dimer, antithrombin Ⅲ), immunoglobulin (IgA, IgM, IgG), lymphocyte subsets count index (CD3+, CD3+CD4+, CD4+/CD8+) and adverse reactions were compared between the two groups after 4 weeks of treatment.Results After treatment, serum albumin and IgG in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group (P<0.05). After treatment, the platelet, urine protein/urine creatinine ratio and fibrinogen in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the levels of total cholesterol, D-dimer, antithrombin Ⅲ, IgA, IgM, CD3+, CD3+CD4+ and CD4+/CD8+ between the two groups after treatment (P>0.05).Conclusion Huaiqihuang granules combined with prednisone acetate can reduce the level of urinary protein in children with PNS in a short time, increase the level of albumin, maintain the normal level of immunoglobulin IgG, improve platelets and fibrinogen, so as to improve the hypercoagulable state of children, with higher safety.

参考文献/References:

[1]李秋,李永柏,杨锡强,等.儿童原发性肾病综合征免疫发病机理研究[J].重庆医学,2002,31(2):102-103[2]Bobrova LA,Kozlovskaya NL.Thromboembolic complications in nephrotic syndrome[J].Ter Arkh,2020,92(6):105-116.[3]Kalra S,Daryani H,Saxena A,et al.Infectious complications in children with nephrotic syndrome: Can they be prevented?[J].Med J Armed Forces India,2022,78(2):170-174.[4]钟超,彭娟,石宇媚,等.槐杞黄颗粒治疗儿童原发性肾病综合征的效果分析[J].深圳中西医结合杂志,2021,31(12):44-45.[5]伊力江·吐洪江,孙亮,白玲.槐杞黄颗粒联合他克莫司治疗儿童激素耐药型肾病综合征疗效及对肾损伤的保护作用[J].中国中西医结合肾病杂志,2022,23(9):802-804.[6]中华医学会儿科学分会肾脏学组.儿童激素敏感、复发/依赖肾病综合征诊治循证指南(2016)[J].中华儿科杂志,2017,55(10):729-734. [7]Noone DG,Iijima K,Parekh R.Idiopathic nephrotic syndrome in children[J].Lancet,2018,392(10141):61-74.[8]Jaber BA,Azat NFA,Al-Daffaie AA.Complications of nephrotic syndrome in children[J].Wiad Lek,2022,75(9 pt 2):2226-2232. [9]Kelddal S,Nykj?覺r KM,Gregersen JW,et al.Prophylactic anticoagulation in nephrotic syndrome prevents thromboembolic complications[J].BMC Nephrology,2019,20(1):139.[10]郝雅静,陈小龙,蔡怀卿,等.原发性肾病综合征胸腔镜肺叶切除术后多发血栓形成1例报告及文献复习[J].临床小儿外科杂志,2022,21(1):93-96.[11]马颐姣,高晓洁,贾实磊,等.儿童原发性肾病综合征并发颅内静脉血栓的临床特点及预后[J].中国小儿急救医学,2019,26(4):301-304． [12]Wireko F,Nanduri S,Lyonga Ngonge A,et al.A Case of a Thrombotic Storm (Arterial and Venous) in Nephrotic Syndrome[J].Cureus,2022,14(7):e27505. [13]Oray M,Abu SK,Ebrahimiadib N,et al.Longterm side effects of glucocorticoids[J].Expert Opin Drug Saf,2016,15(4):457-465[14]郑志方,刘利蕊,王文涛,等.阿奇霉素联合槐杞黄颗粒对儿童原发性肾病综合征合并支原体感染的临床疗效及肾功能的影响[J].河北医学,2022,28(7):1205-1209. [15]叶婷婷,金莎,杨瑶,等.槐杞黄颗粒对糖尿病肾病的疗效及其机制研究[J].临床内科杂志,2020,37(2):98-101.[16]耿海云,曹力,王薇,等.槐杞黄颗粒治疗儿童原发性肾病综合征的前瞻性随机对照临床研究[J].中国当代儿科杂志,2015,17(1):31-34.[17]Zhang Y,Chang J,Gao H,et al.Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation [J].Pharm Biol,2021,59(1):1425-1431.[18]Chen W,Kan H,Qin M,et al.Investigation of the Active Compounds and Important Pathways of Huaiqihuang Granule for the Treatment of Immune Thrombocytopenia Using Network Pharmacology and Molecular Docking[J].Biomed Res Int,2023,2023:5984361. [19]Yang G,Yang H,Cui S,et al.Effect of Huaiqihuang Granules Combined with Comprehensive Nursing on Children with Primary Nephrotic Syndrome[J].J Healthc Eng,2022,2022:3279503. [20]杨丽潇.ACTH和槐杞黄颗粒对肾上腺皮质的影响[D].天津:天津医科大学,2017.[21]陆玮,王丽娜,郝志宏,等.槐杞黄颗粒辅助治疗儿童原发性激素敏感型肾病综合征的疗效[J].国际医药卫生导报,2021,27(16):2509-2514.[22]李智超,郭夏,王石,等.槐杞黄颗粒辅助治疗系统性红斑狼疮复发患儿疗效及对免疫功能的影响[J]. 实用医学杂志,2021,37(4):525-529.[23]包智影,张智,杜亚飞,等.微生物法提取黄精多糖及体外降脂功能评价[J].中南林业科技大学学报,2021,41(5):142-151.

相似文献/References:

[1]刘广涛,关凤军,董 晨.原发性肾病综合征患儿肾组织P-gp170蛋白和mRNA表达与临床病理及预后的关系[J].医学信息,2018,31(21):61.[doi:10.3969/j.issn.1006-1959.2018.21.017]
　LIU Guang-tao,GUAN Feng-jun,DONG Chen.Relationship between the Expression of p-gp170 Protein and mRNA in Renal Tissue of Children with Primary Nephrotic Syndrome and Clinical Pathology and Prognosis[J].Journal of Medical Information,2018,31(01):61.[doi:10.3969/j.issn.1006-1959.2018.21.017]
[2]钱朝庆,刘 淼,王家平,等.肾病综合征合并肾静脉血栓应用阿加曲班疗效评价[J].医学信息,2018,31(21):135.[doi:10.3969/j.issn.1006-1959.2018.21.038]
　QIAN Chao-qing,LIU Miao,WANG Jia-ping,et al.Clinical Efficacy Evaluation of Argatroban in Nephrotic Syndrome with Renal Vein Thrombosis[J].Journal of Medical Information,2018,31(01):135.[doi:10.3969/j.issn.1006-1959.2018.21.038]
[3]王世芳.预见性护理对肾病综合征患者并发症发生率及护理满意度的影响[J].医学信息,2020,33(01):188.[doi:10.3969/j.issn.1006-1959.2020.01.063]
　WANG Shi-fang.Effect of Predictive Nursing on the Incidence of Complications and Nursing Satisfaction in Patients with Nephrotic Syndrome[J].Journal of Medical Information,2020,33(01):188.[doi:10.3969/j.issn.1006-1959.2020.01.063]
[4]刘廷胜.低分子肝素结合瑞舒伐他汀与醋酸泼尼松对肾病综合征患者肾功能及炎症因子的影响[J].医学信息,2020,33(08):158.[doi:10.3969/j.issn.1006-1959.2020.08.052]
　LIU Ting-sheng.Effect of Low Molecular Weight Heparin Combined with Rosuvastatin and Prednisone Acetate in the Treatment of Patients with Nephrotic Syndrome[J].Journal of Medical Information,2020,33(01):158.[doi:10.3969/j.issn.1006-1959.2020.08.052]
[5]王艳秋.黄葵胶囊联合醋酸泼尼松治疗原发性肾病综合征的疗效[J].医学信息,2020,33(17):168.[doi:10.3969/j.issn.1006-1959.2020.17.051]
　WANG Yan-qiu.The Effect of Huangkui Capsule Combined with Prednisone Acetate in the Treatment of Primary Nephrotic Syndrome[J].Journal of Medical Information,2020,33(01):168.[doi:10.3969/j.issn.1006-1959.2020.17.051]
[6]周 琳,方界界.不同白蛋白水平的肾病综合征患者凝血功能比较[J].医学信息,2020,33(20):94.[doi:10.3969/j.issn.1006-1959.2020.20.027]
　ZHOU Lin,FANG Jie-jie.Comparison of Coagulation Function in Nephrotic Syndrome Patients with Different Albumin Levels[J].Journal of Medical Information,2020,33(01):94.[doi:10.3969/j.issn.1006-1959.2020.20.027]
[7]姚安琪,郑艳辉.托伐普坦治疗肾脏疾病的应用[J].医学信息,2020,33(24):53.[doi:10.3969/j.issn.1006-1959.2020.24.015]
　YAO An-qi,ZHENG Yan-hui.Application of Tolvaptan in Treating Kidney Disease[J].Journal of Medical Information,2020,33(01):53.[doi:10.3969/j.issn.1006-1959.2020.24.015]
[8]谭军华,金小掺,冷雪姣.糖皮质激素联合他克莫司对肾病综合征患者肾功能及炎症因子水平的影响[J].医学信息,2023,36(20):129.[doi:10.3969/j.issn.1006-1959.2023.20.025]
　TAN Jun-hua,JIN Xiao-shan,LENG Xue-jiao.Effect of Glucocorticoid Combined with Tacrolimus on Renal Function and Inflammatory Factor Levels in Patients with Nephrotic Syndrome[J].Journal of Medical Information,2023,36(01):129.[doi:10.3969/j.issn.1006-1959.2023.20.025]

更新日期/Last Update: 1900-01-01