[1]李书元.氟西汀联合阿立哌唑治疗抑郁症的临床效果及对患者睡眠质量的影响[J].医学信息,2024,37(02):124-127.[doi:10.3969/j.issn.1006-1959.2024.02.024]
　LI Shu-yuan.Clinical Effect of Fluoxetine Combined with Aripiprazole in the Treatment of Depression and its Effect on Sleep Quality[J].Journal of Medical Information,2024,37(02):124-127.[doi:10.3969/j.issn.1006-1959.2024.02.024]
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氟西汀联合阿立哌唑治疗抑郁症的临床效果及对患者睡眠质量的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年02期
页码:
124-127
栏目:
论著
出版日期:
2024-01-15

文章信息/Info

Title:
Clinical Effect of Fluoxetine Combined with Aripiprazole in the Treatment of Depression and its Effect on Sleep Quality
文章编号:
1006-1959（2024）02-0124-04
作者:
李书元
（天津建华医院精神康复二科，天津 300393）
Author(s):
LI Shu-yuan
(The Second Department of Mental Rehabilitation,Tianjin Jianhua Hospital,Tianjin 300393,China)
关键词:
抑郁症; 氟西汀; 阿立哌唑; 睡眠质量; 心理弹性; 负性思维
Keywords:
Depression; Fluoxetine; Aripiprazole; Sleep quality; Psychological resilience; Negative thinking
分类号:
R749.4+1
DOI:
10.3969/j.issn.1006-1959.2024.02.024
文献标志码:
A
摘要:
目的 研究氟西汀联合阿立哌唑治疗抑郁症的临床效果及对患者睡眠质量的影响。方法 选取2021年4月-2023年4月天津建华医院收治的98例抑郁症患者，采用随机数字表法分为对照组与观察组，各49例。对照组接受氟西汀治疗，观察组在其基础上联合阿立哌唑治疗。比较两组临床疗效、抑郁症状[汉密尔顿抑郁量表（HAMD）、Beck抑郁问卷（BDI）]、负性自动思维问卷（ATQ）、匹兹堡睡眠质量指数（PSQI）及Connor-Davidson心理弹性量表（CD-RISC）评分。结果 观察组总有效率高于对照组（P＜0.05）；2组HAMD、BDI评分低于治疗前，且观察组HAMD、BDI评分低于对照组（P＜0.05）；2组ATQ评分低于治疗前，且观察组ATQ评分低于对照组（P＜0.05）；2组PSQI评分低于治疗前，CD-RISC评分高于治疗前，且观察组PSQI评分低于对照组，CD-RISC评分高于对照组（P＜0.05）。结论 氟西汀联合阿立哌唑在抑郁症治疗中可发挥确切作用，其临床疗效突出，可减轻患者抑郁症状，消除负性思维，改善其睡眠质量与心理弹性。
Abstract:
bjective To study the clinical effect of fluoxetine combined with aripiprazole in the treatment of depression and its effect on sleep quality.Methods A total of 98 patients with depression admitted to Tianjin Jianhua Hospital from April 2021 to April 2023 were selected and divided into control group and observation group by random number table method, with 49 patients in each group. The control group was treated with fluoxetine, and the observation group was treated with aripiprazole on the basis of the control group. The clinical efficacy, depressive symptoms [Hamilton Depression Scale (HAMD), Beck Depression Inventory (BDI)], Automatic Thought Questionnaire (ATQ), Pittsburgh Sleep Quality Index (PSQI) and Connor-Davidson Resilience Scale (CD-RISC) scores were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The scores of HAMD and BDI in the two groups after treatment were lower than those before treatment, and the scores of HAMD and BDI in the observation group were lower than those in the control group (P<0.05). After treatment, the ATQ scores (frequency and confidence) of the two groups were lower than those before treatment, and the ATQ scores (frequency and confidence) of the observation group were lower than those of the control group (P<0.05). The PSQI score of the two groups after treatment was lower than that before treatment, and the CD-RISC score was higher than that before treatment, while the PSQI score of the observation group was lower than that of the control group, and the CD-RISC score was higher than that of the control group (P<0.05).Conclusion Fluoxetine combined with aripiprazole can play an exact role in the treatment of depression, and its clinical efficacy is outstanding. Meanwhile, it can reduce the depressive symptoms of patients, eliminate negative thinking, and improve their sleep quality and psychological elasticity.

参考文献/References:

[1]Cipriani A,Furukawa TA,Salanti G,et al.Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder:a systematic review and network meta-analysis[J].Lancet,2018,39(1):1357-1366.[2]康延海,李佳,董洁,等.氟西汀联合认知行为治疗对急性期非典型特征抑郁症疗效及负性自动思维和自杀意念的影响[J].疑难病杂志,2022,21(2):182-187.[3]李少华,易筱荣,张翠芳,等.奥氮平联合氟西汀治疗对抑郁症患者血清NE水平以及抑郁情绪影响的临床研究[J].现代生物医学进展,2021,21(23):4578-4582.[4]朱冬冬,王桢淑.箱庭疗法联合氟西汀对轻中度抑郁症伴失眠患者的疗效分析[J].中国现代医学杂志,2021,31(18):60-63.[5]黄同旭,黄春梅,韩攸村,等.米氮平联合氟西汀治疗抑郁症的临床疗效及对患者TNF-α、IL-1β、IL-10水平的影响[J].精神医学杂志,2021,34(1):43-46.[6]朱冬冬,王桢淑.箱庭疗法联合氟西汀对轻中度抑郁症伴失眠患者的疗效分析[J].中国现代医学杂志,2021,31(18):60-63.[7]常晓娟,赵千渃,赵璇,等.阿立哌唑联合舍曲林治疗精神分裂症伴抑郁症临床疗效观察[J].陕西医学杂志,2020,49(12):1669-1672.[8]孙庆芳,王亚平.阿立哌唑联合度洛西汀治疗抑郁症的临床研究[J].现代药物与临床,2020,35(4):712-716.[9]杨世涛,祝一虹,唐文新.阿立哌唑联合度洛西汀对难治性抑郁的疗效及对血管内皮生长因子的作用研究[J].中国临床药理学与治疗学,2020,25(8):937-942.[10]王科平,邢文静,韩宇扬.阿立哌唑联合草酸艾司西酞普兰在重度抑郁症治疗中的应用分析[J].川北医学院学报,2020,35(1):42-44.[11]刘文杰,张军亚.艾司西酞普兰和氟西汀对抑郁症的疗效和认知改善情况对比[J].国际精神病学杂志,2020,47(1):78-79,84.[12]Morris G,Reiche V,Maria E,et al.Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis[J].Molecular Neurobiology,2018,13(1):231-233.[13]陈连洲,李松华,蒲犇.阿立哌唑联合草酸艾司西酞普兰对重度抑郁患者多巴胺、5-羟色胺和皮质醇的影响研究[J].中国临床药理学与治疗学,2019,24(4):446-450.[14]马玉娟,鲁陆.阿米替林联合氟西汀治疗抑郁症的临床研究[J].现代药物与临床,2018,33(7):1644-1647.[15]黄雪萍,张涛,黄金园,等.氟西汀联用利培酮对精神分裂症患者焦虑、抑郁状态的影响[J].国际精神病学杂志,2018,45(3):452-455.[16]白轩,孙宏利,卜岚,等.丁螺环酮联合氟西汀治疗抑郁症的疗效分析[J].脑与神经疾病杂志,2018,26(5):265-268.[17]韩兴玲,王惠玲.氟西汀对抑郁症患者认知记忆功能及ERP-P300的影响[J].西南国防医药,2018,28(4):334-337.[18]张超,闻荣海.阿立哌唑和锂盐对难治性抑郁症增效作用的对照研究[J].精神医学杂志,2021,34(2):163-166.[19]许珍,高成,邹峰.阿立哌唑联合阿戈美拉汀对抑郁症患者抑郁情绪、睡眠质量及神经递质指标的影响[J].徐州医科大学学报,2022,42(2):123-128.[20]蔡广超,熊旻.度洛西汀联合阿立哌唑治疗伴躯体症状抑郁症的疗效观察[J].河北医药,2018,40(2):264-266.[21]杨树芬,杨立身,夏永兵,等.阿立哌唑联合舍曲林对精神分裂症合并抑郁患者的疗效[J].中国全科医学,2018,21(2):225-226.[22]Li K,Shen S,Ji YT,et al.Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling[J].Science Bulletin,2018,34(2):1-9.

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更新日期/Last Update: 1900-01-01