[1]李 琳,李仲均.普伐他汀的作用机制及防治子痫前期的研究[J].医学信息,2024,37(05):178-181.[doi:10.3969/j.issn.1006-1959.2024.05.034]
 LI Lin,LI Zhong-jun.Study on the Mechanism of Pravastatin and its Prevention and Treatment of Preeclampsia[J].Journal of Medical Information,2024,37(05):178-181.[doi:10.3969/j.issn.1006-1959.2024.05.034]
点击复制

普伐他汀的作用机制及防治子痫前期的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年05期
页码:
178-181
栏目:
综述
出版日期:
2024-03-01

文章信息/Info

Title:
Study on the Mechanism of Pravastatin and its Prevention and Treatment of Preeclampsia
文章编号:
1006-1959(2024)05-0178-04
作者:
李 琳李仲均
(1.广东医科大学第一临床医学院,广东 湛江 524002;2.南方医科大学附属东莞医院妇产科,广东 东莞 523000)
Author(s):
LI LinLI Zhong-jun
(1.The First Clinical Medical College,Guangdong Medical University,Zhanjiang 524002,Guangdong,China;2.Department of Obstetrics and Gynecology,Affiliated Dongguan Hospital,Southern Medical University,Dongguan 523000,Guangdong,China)
关键词:
普伐他汀子痫前期妊娠期高血压疾病
Keywords:
PravastationPreeclampsiaHypertensive disorders of pregnancy
分类号:
R714.24+4
DOI:
10.3969/j.issn.1006-1959.2024.05.034
文献标志码:
A
摘要:
子痫前期是造成孕产妇及新生儿死亡的主要原因之一,而可用于防治子痫前期的药物及治疗方法有限。近年来,对于可用于防治子痫前期的新药物越来越受到关注。普伐他汀可以通过调节胎盘生长因子平衡、增加一氧化氮生成、减轻氧化应激作用等防治子痫前期。本文就普伐他汀的作用机制及其防治子痫前期的相关研究进展进行了综述。
Abstract:
Preeclampsia is one of the main causes of maternal and neonatal death, and the drugs and treatment methods that can be used to prevent and treat preeclampsia are limited. In recent years, more and more attention has been paid to new drugs that can be used to prevent and treat preeclampsia. Pravastatin can prevent and treat preeclampsia by regulating placental growth factor balance, increasing nitric oxide production, and reducing oxidative stress. This article reviews the mechanism of pravastatin and its related research progress in the prevention and treatment of preeclampsia.

参考文献/References:

[1]Say L,Chou D,Gemmill A,et al.Global causes of maternal death: a WHO systematic analysis [J].The Lancet Global health,2014,2(6):e323-e333.[2]Poon L C, Shennan A, Hyett J A, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention[J].International Journal of Gynaecology and Obstetrics,2019,145 Suppl 1(Suppl 1):1-33.[3]Davis EF,Lazdam M,Lewandowski AJ,et al.Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review [J].Pediatrics,2012,129(6):e1552-e1561.[4]Rep A,Ganzevoort W,Bonsel GJ,et al.Psychosocial impact of early-onset hypertensive disorders and related complications in pregnancy [J].American Journal of Obstetrics and Gynecology,2007,197(2):158.e1-158.e6.[5]Hoedjes M,Berks D,Vogel I,et al.Postpartum depression after mild and severe preeclampsia [J]. Journal of women’s health (2002),2011,20(10):1535-1542.[6]ACOG Practice Bulletin No.202: Gestational Hypertension and Preeclampsia [J].Obstetrics and gynecology,2019,133(1):1.[7]Smith DD,Costantine MM.The role of statins in the prevention of preeclampsia [J].American journal of Obstetrics and Gynecology,2022,226(2s):S1171-S1181.[8]Hirota T,Fujita Y,Ieiri I.An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins [J].Expert Opinion on Drug Metabolism & Toxicology,2020,16(9):809-822.[9]Chang JC,Chen YJ,Chen IC,et al.Perinatal Outcomes After Statin Exposure During Pregnancy [J].JAMA network open,2021,4(12):e2141321.[10]De Alwis N,Beard S,Mangwiro YT,et al.Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction [J].Pregnancy Hypertension,2020,20:83-91.[11]Costantine MM,Clifton RG,Boekhoudt TM,et al.Long-term neurodevelopmental follow-up of children exposed to pravastatin in utero [J].American Journal of Obstetrics and Gynecology,2023,229(2):153.e1-153.e12.[12]Roberts JM,Hubel CA.The two stage model of preeclampsia: variations on the theme [J]. Placenta, 2009,30 Suppl A(Suppl A):S32-S37.[13]Croke L.Gestational Hypertension and Preeclampsia: A Practice Bulletin from ACOG [J]. American Family Physician,2019,100(10):649-650.[14]Eid J,Rood KM,Costantine MM.Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy [J].Obstetrics and gynecology clinics of North America,2023,50(1):79-88.[15]Mészáros B,Veres DS,Nagyistók L,et al.Pravastatin in preeclampsia: A meta-analysis and systematic review [J].Frontiers in medicine,2022,9:1076372.[16]Levine RJ,Lam C,Qian C,et al.Soluble endoglin and other circulating antiangiogenic factors in preeclampsia [J].The New England Journal of Medicine,2006,355(10):992-1005.[17]Zeisler H,Llurba E,Chantraine F,et al.Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia [J].The New England Journal of Medicine,2016,374(1):13-22.[18]Herraiz I,Llurba E,Verlohren S,et al.Update on the Diagnosis and Prognosis of Preeclampsia with the Aid of the sFlt-1/ PlGF Ratio in Singleton Pregnancies [J].Fetal Diagnosis and Therapy,2018,43(2):81-89.[19]Ma’ayeh M,Rood KM,Kniss D,et al.Novel Interventions for the Prevention of Preeclampsia [J].Current Hypertension Reports,2020,22(2):17.[20]Pánczél Z,Supák D,Kovács B,et al.Effect of pravastatin on tetrahydrobiopterin-sensitive and -resistant NO synthase activity of preeclamptic placentas[J].Orvosi Hetilap,2020,161(10):389-395.[21]Pánczél Z,Kukor Z,Supák D,et al.Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas [J].BMC Pregnancy and Childbirth,2019,19(1):426.[22]Chimini JS,Possomato-Vieira JS,Da Silva MLS,et al.Placental nitric oxide formation and endothelium-dependent vasodilation underlie pravastatin effects against angiogenic imbalance, hypertension in pregnancy and intrauterine growth restriction [J].Basic & Clinical Pharmacology & Toxicology,2019,124(4):385-393.[23]Wenger NK.Juggling Multiple Guidelines: A Woman’s Heart in the Balance [J].Journal of Women’s Health (2002),2016,25(3):213-221.[24]Kr?覿ker K,O’driscoll JM,Schütte T,et al.Statins Reverse Postpartum Cardiovascular Dysfunction in a Rat Model of Preeclampsia [J].Hypertension (Dallas, Tex:1979),2020,75(1):202-210.[25]Lefkou E,Mamopoulos A,Dagklis T,et al.Pravastatin improves pregnancy outcomes in obstetric antiphospholipid syndrome refractory to antithrombotic therapy [J].The Journal of Clinical Investigation,2016,126(8):2933-2940.[26]Mendoza M,Ferrer-Oliveras R,Bonacina E,et al.Evaluating the Effect of Pravastatin in Early-Onset Fetal Growth Restriction: A Nonrandomized and Historically Controlled Pilot Study [J].American Journal of Perinatology,2021,38(14):1472-1479.[27]D?觟bert M,Varouxaki AN,Mu AC,et al.Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia [J].Circulation,2021,144(9):670-679.[28]Lefkou E,Mamopoulos A,Fragakis N,et al.Clinical improvement and successful pregnancy in a preeclamptic patient with antiphospholipid syndrome treated with pravastatin [J].Hypertension (Dallas,Tex : 1979),2014,63(5):e118-e119.[29]Lefkou E,Varoudi K,Pombo J,et al.Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism [J].Biochemical Pharmacology,2020,182:114217.

相似文献/References:

[1]李仲均,黄丽姗,曾带娣,等.孕妇血清维生素A、维生素E、25-羟基维生素D与 子痫前期的相关性研究[J].医学信息,2019,32(11):63.[doi:10.3969/j.issn.1006-1959.2019.11.018]
 LI Zhong-jun,HUANG Li-shan,ZENG Dai-di,et al.Correlation between Serum Vitamin A,Vitamin E,25-hydroxyvitamin D and Pre-eclampsia in Pregnant Women[J].Journal of Medical Information,2019,32(05):63.[doi:10.3969/j.issn.1006-1959.2019.11.018]
[2]尤 鑫,崔洪艳.PDGF与子痫前期相关性的研究进展[J].医学信息,2019,32(17):53.[doi:10.3969/j.issn.1006-1959.2019.17.017]
 YOU Xin,CUI Hong-yan.Advances in Research on the Relationship between PDGF and Preeclampsia[J].Journal of Medical Information,2019,32(05):53.[doi:10.3969/j.issn.1006-1959.2019.17.017]
[3]蒋峰丽,马亚楠,乌 丽.胎盘生长因子在子痫前期早期诊断中的临床价值[J].医学信息,2019,32(16):160.[doi:10.3969/j.issn.1006-1959.2019.16.054]
 JIANG Feng-li,MA Ya-nan,WU Li.Clinical Value of Placental Growth Factor in Early Diagnosis of Preeclampsia[J].Journal of Medical Information,2019,32(05):160.[doi:10.3969/j.issn.1006-1959.2019.16.054]
[4]霍春霞,谢 玲,张爱萍.早期干预治疗对早期筛查阳性子痫前期孕妇妊娠结局的影响[J].医学信息,2023,36(19):134.[doi:10.3969/j.issn.1006-1959.2023.19.029]
 HUO Chun-xia,XIE Ling,ZHANG Ai-ping.Effect of Early Intervention on Pregnancy Outcome of Pregnant Women with Early Screening Positive Preeclampsia[J].Journal of Medical Information,2023,36(05):134.[doi:10.3969/j.issn.1006-1959.2023.19.029]
[5]史爱红,刘爱玲,封 玲,等.凝血功能指标对不同类型子痫前期的诊断价值[J].医学信息,2020,33(21):90.[doi:10.3969/j.issn.1006-1959.2020.21.026]
 SHI Ai-hong,LIU Ai-ling,FENG Ling,et al.The Diagnostic Value of Coagulation Function Indexes for Different Types of Preeclampsia[J].Journal of Medical Information,2020,33(05):90.[doi:10.3969/j.issn.1006-1959.2020.21.026]
[6]王金凤,王克涛.红细胞压积、血清纤维蛋白原、D-二聚体及尿白蛋白/尿肌酐比值在子痫前期诊断中的价值[J].医学信息,2020,33(20):156.[doi:10.3969/j.issn.1006-1959.2020.20.049]
 WANG Jin-feng,WANG Ke-tao.The Value of Hematocrit,Serum Fibrinogen,D-dimer and Urine Albumin/Urinary Creatinine Ratio in the Diagnosis of Preeclampsia[J].Journal of Medical Information,2020,33(05):156.[doi:10.3969/j.issn.1006-1959.2020.20.049]
[7]杨双燕,杨琦芳,李银凤.子痫前期病因及发病机制的研究[J].医学信息,2021,34(04):52.[doi:10.3969/j.issn.1006-1959.2021.04.014]
 YANG Shuang-yan,YANG Qi-fang,LI Yin-feng.Study on the Etiology and Pathogenesis of Preeclampsia[J].Journal of Medical Information,2021,34(05):52.[doi:10.3969/j.issn.1006-1959.2021.04.014]
[8]马梦茹,吴胜军,赵宗霞,等.子痫前期患者相关生化指标的研究进展[J].医学信息,2022,35(22):176.[doi:10.3969/j.issn.1006-1959.2022.22.043]
 MA Meng-ru,WU Sheng-jun,ZHAO Zong-xia,et al.Research Progress of Biochemical Indexes in Patients with Preeclampsia[J].Journal of Medical Information,2022,35(05):176.[doi:10.3969/j.issn.1006-1959.2022.22.043]
[9]车 莹,杨 丽,孙 昊.前瞻性护理对妊娠高血压轻度子痫前期患者血压及自我管理能力的影响[J].医学信息,2022,35(02):190.[doi:10.3969/j.issn.1006-1959.2022.02.051]
 CHE Ying,YANG Li,SUN Hao.Effect of Prospective Nursing on Blood Pressure and Self-management Ability of Patientswith Mild Preeclampsia of Pregnancy-induced Hypertension[J].Journal of Medical Information,2022,35(05):190.[doi:10.3969/j.issn.1006-1959.2022.02.051]
[10]郭 丽,黄淑娟,隋红梅.子痫前期的药物预防研究[J].医学信息,2023,36(23):170.[doi:10.3969/j.issn.1006-1959.2023.23.043]
 GUO Li,HUANG Shu-juan,SUI Hong-mei.Research on Drug Prevention of Preeclampsia[J].Journal of Medical Information,2023,36(05):170.[doi:10.3969/j.issn.1006-1959.2023.23.043]

更新日期/Last Update: 1900-01-01