[1]王金凤,王克涛.红细胞压积、血清纤维蛋白原、D-二聚体及尿白蛋白/尿肌酐比值在子痫前期诊断中的价值[J].医学信息,2020,33(20):156-158.[doi:10.3969/j.issn.1006-1959.2020.20.049]
　WANG Jin-feng,WANG Ke-tao.The Value of Hematocrit,Serum Fibrinogen,D-dimer and Urine Albumin/Urinary Creatinine Ratio in the Diagnosis of Preeclampsia[J].Medical Information,2020,33(20):156-158.[doi:10.3969/j.issn.1006-1959.2020.20.049]
点击复制

红细胞压积、血清纤维蛋白原、D-二聚体及尿白蛋白/尿肌酐比值在子痫前期诊断中的价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年20期
页码:
156-158
栏目:
诊疗技术
出版日期:
2020-10-15

文章信息/Info

Title:
The Value of Hematocrit,Serum Fibrinogen,D-dimer and Urine Albumin/Urinary Creatinine Ratio in the Diagnosis of Preeclampsia
文章编号:
1006-1959（2020）20-0156-03
作者:
王金凤; 王克涛
（南京医科大学附属苏州科技城医院妇产科，江苏 苏州 215000）
Author(s):
WANG Jin-feng; WANG Ke-tao
(Department of Obstetrics and Gynecology,Suzhou Science and Technology City Hospital,Nanjing Medical University, Suzhou 215000,Jiangsu,China)
关键词:
子痫前期; 纤维蛋白原; 红细胞压积; D-二聚体; 尿白蛋白/尿肌酐比值
Keywords:
Preeclampsia; Fibrinogen; Hematocrit; D-dimer; Urinary albumin/urinary creatinine ratio
分类号:
R714.244
DOI:
10.3969/j.issn.1006-1959.2020.20.049
文献标志码:
A
摘要:
目的 探讨红细胞压积、血清纤维蛋白原、D-二聚体及尿白蛋白/尿肌酐比值（UACR）在子痫前期（PE）诊断中的价值。方法 选择2017年6月~2019年12月我院妇产科收治的PE孕妇87例，根据中华医学会妇产科学分会制定的《妊娠期高血压疾病诊治指南（2015）》分为轻度PE组（49例）和重度PE组（38例），另选同期于我院分娩的健康孕妇45例作为对照组。检测三组红细胞压积、血清纤维蛋白原、D-二聚体水平、尿白蛋白和肌酐水平，并计算UACR，分析PE孕妇纤维蛋白原、红细胞压积、D-二聚体水平及UACR的变化情况。结果 轻度PE组、重度PE组红细胞压积、纤维蛋白原、D-二聚体、尿白蛋白、尿肌酐、UACR及24 h尿蛋白量均高于对照组，且重度PE组高于轻度PE组，差异有统计学意义（P＜0.05）；Logistic回归分析显示，维蛋白原、D-二聚体、UACR均是PE发病的独立危险因素（P＜0.05）。结论 PE孕妇红细胞压积、血清纤维蛋白原、D-二聚体水平、尿白蛋白和肌酐水平存在异常，临床上检测D-二聚体水平及UACR可作为孕妇PE的评估指标，具有重要临床价值。
Abstract:
Objective To investigate the value of hematocrit, serum fibrinogen, D-dimer and urine albumin/urine creatinine ratio (UACR) in the diagnosis of preeclampsia (PE).Methods 87 cases of PE pregnant women admitted to the Department of Obstetrics and Gynecology in our hospital from June 2017 to December 2019 were selected and divided into the mild PE group according to the "Guidelines for the Diagnosis and Treatment of Hypertension in Pregnancy (2015)" formulated by the Chinese Medical Association Obstetrics and Gynecology Branch (49 cases) and severe PE group (38 cases). Another 45 healthy pregnant women who gave birth in our hospital during the same period were selected as the control group. Detect three groups of hematocrit, serum fibrinogen, D-dimer levels, urine albumin and creatinine levels, and calculate UACR, analyze the levels of fibrinogen, hematocrit, D-dimer and UACR in PE pregnant women changes.Results The levels of hematocrit, fibrinogen, D-dimer, urine albumin, urine creatinine, UACR and 24 h urine protein in the mild PE group and severe PE group were higher than those the control group, and the severe PE group was higher than the mild PE group, the difference was statistically significant (P<0.05); Logistic regression analysis showed that pro-vigin, D-dimer, and UACR were all independent risk factors for PE (P<0.05).Conclusion The hematocrit, serum fibrinogen, D-dimer level, urine albumin and creatinine levels of pregnant women with PE were abnormal. The clinical detection of D-dimer level and UACR could be used as the evaluation index of pregnant women’s PE, which had important clinical significance value.

参考文献/References:

[1]Guida JP,Parpinelli MA,Surita FG,et al.The impact of proteinuria on maternal and perinatal outcomes among women with pre-eclampsia[J].International Journal of Gynecology&Obstetrics,2018,143(1):101-107. [2]李艳霞,岳莉,刘琳.重度子痫前期患者动态血压监测与肾功能变化情况分析[J].中国妇幼保健,2019,34(17):3955-3957. [3]马擘,崔洪艳,陈叙.子痫前期诊治新进展[J].中华危重症医学杂志（电子版）,2019,12(5):353-357. [4]杨孜,张为远.妊娠期高血压疾病诊治指南(2015)解读[J].中国实用妇科与产科杂志,2015,31(10):886-893. [5]徐金良,张宁芝,梅莉.早发型重度子痫前期患者不同终止妊娠时机的母婴结局分析[J].中国计划生育学杂志,2019,27(9):1201-1204. [6]潘膨远.血清白蛋白与24h尿蛋白定量对早发重度子痫前期预后的评估作用分析[J].吉林医学,2018,39(7):1227-1229. [7]王玉.凝血四项、血清TNF-α及D-D在子痫前期患者中的临床诊断意义[J].湖南师范大学学报（医学版）,2019,16(6):126-128. [8]潘复亮.诊断弥漫性血管内凝血中凝血检验指标的价值分析[J].临床检验杂志（电子版）,2020,9(3):198. [9]杨威威,孙锡红,秦丽,等.产前低水平纤维蛋白原联合血栓弹力图检测与产后出血的相关性研究[J].河北医科大学学报,2020,41(1):109-113. [10]高莹,梁佩丽,胡少娜.随机尿白蛋白/肌酐比值与妊娠期高血压疾病的相关性研究[J].中国计划生育和妇产科,2018,10(12):60-63.

相似文献/References:

[1]和珍珍,吴彦洪,刘艳,等.凝血指标测定对诊断胎盘早剥的价值分析[J].医学信息,2018,31(01):153.[doi:10.3969/j.issn.1006-1959.2018.01.060]
　HE Zhen-zhen,WU Yan-hong,LIU Yan,et al.Value Analysis of Coagulation Index in Diagnosing Placental Abruption[J].Medical Information,2018,31(20):153.[doi:10.3969/j.issn.1006-1959.2018.01.060]
[2]赵 静.血浆纤维蛋白原和CA724水平在胃癌患者的变化及临床意义[J].医学信息,2018,31(24):82.[doi:10.3969/j.issn.1006-1959.2018.24.021]
　ZHAO Jing.Changes and Clinical Significance of Plasma Fibrinogen and CA724 Levels in Patients with Gastric Cancer[J].Medical Information,2018,31(20):82.[doi:10.3969/j.issn.1006-1959.2018.24.021]
[3]朱婷樱,鲍扬漪.术前LMR和FIB的检测对结直肠中分化腺癌患者的临床意义[J].医学信息,2019,32(04):94.[doi:10.3969/j.issn.1006-1959.2019.04.031]
　ZHU Ting-ying,BAO Yang-yi.Clinical Significance of Preoperative LMR and FIB Detection in Patients with Differentiated Adenocarcinoma in Colorectal[J].Medical Information,2019,32(20):94.[doi:10.3969/j.issn.1006-1959.2019.04.031]
[4]李仲均,黄丽姗,曾带娣,等.孕妇血清维生素A、维生素E、25-羟基维生素D与 子痫前期的相关性研究[J].医学信息,2019,32(11):63.[doi:10.3969/j.issn.1006-1959.2019.11.018]
　LI Zhong-jun,HUANG Li-shan,ZENG Dai-di,et al.Correlation between Serum Vitamin A,Vitamin E,25-hydroxyvitamin D and Pre-eclampsia in Pregnant Women[J].Medical Information,2019,32(20):63.[doi:10.3969/j.issn.1006-1959.2019.11.018]
[5]王 嫣,戴 夫,彭 琼.循环纤维蛋白原与白蛋白比值、循环纤维蛋白原与前白蛋白比值联合癌胚抗原对结直肠癌的早期诊断价值[J].医学信息,2022,35(14):75.[doi:10.3969/j.issn.1006-1959.2022.14.016]
　WANG Yan,DAI Fu,PENG Qiong.Early Diagnostic Value of Circulating Fibrinogen to Albumin Ratio,Circulating Fibrinogen to Prealbumin Ratio Combined with Carcinoembryonic Antigen in Colorectal Cancer[J].Medical Information,2022,35(20):75.[doi:10.3969/j.issn.1006-1959.2022.14.016]
[6]尤 鑫,崔洪艳.PDGF与子痫前期相关性的研究进展[J].医学信息,2019,32(17):53.[doi:10.3969/j.issn.1006-1959.2019.17.017]
　YOU Xin,CUI Hong-yan.Advances in Research on the Relationship between PDGF and Preeclampsia[J].Medical Information,2019,32(20):53.[doi:10.3969/j.issn.1006-1959.2019.17.017]
[7]李大千,蒋 云,梅燕萍.抗凝血酶Ⅲ、D-二聚体与纤维蛋白原在 下肢静脉血栓形成中的临床应用[J].医学信息,2019,32(17):167.[doi:10.3969/j.issn.1006-1959.2019.17.057]
　LI Da-qian,JIANG Yun,MEI Yan-ping.Clinical Application of Antithrombin III,D-dimer and Fibrinogen in Venous Thrombosis of Lower Extremity[J].Medical Information,2019,32(20):167.[doi:10.3969/j.issn.1006-1959.2019.17.057]
[8]朱丽娜,王宗立,顾萌萌.UA、Hcy和FIB与颈动脉粥样硬化斑块及 脑梗死关系的分析[J].医学信息,2019,32(18):173.[doi:10.3969/j.issn.1006-1959.2019.18.061]
　ZHU Li-na,WANG Zong-li,GU Meng-meng.Analysis of the Relationship Among UA, Hcy，FIB and Carotid Atherosclerotic Plaque， Cerebral Infarction[J].Medical Information,2019,32(20):173.[doi:10.3969/j.issn.1006-1959.2019.18.061]
[9]蒋峰丽,马亚楠,乌 丽.胎盘生长因子在子痫前期早期诊断中的临床价值[J].医学信息,2019,32(16):160.[doi:10.3969/j.issn.1006-1959.2019.16.054]
　JIANG Feng-li,MA Ya-nan,WU Li.Clinical Value of Placental Growth Factor in Early Diagnosis of Preeclampsia[J].Medical Information,2019,32(20):160.[doi:10.3969/j.issn.1006-1959.2019.16.054]
[10]霍春霞,谢 玲,张爱萍.早期干预治疗对早期筛查阳性子痫前期孕妇妊娠结局的影响[J].医学信息,2023,36(19):134.[doi:10.3969/j.issn.1006-1959.2023.19.029]
　HUO Chun-xia,XIE Ling,ZHANG Ai-ping.Effect of Early Intervention on Pregnancy Outcome of Pregnant Women with Early Screening Positive Preeclampsia[J].Medical Information,2023,36(20):134.[doi:10.3969/j.issn.1006-1959.2023.19.029]

更新日期/Last Update: 1900-01-01