[1]陆 新,龙 瑾.中成药辅助治疗高血压病胰岛素抵抗临床应用规范化研究[J].医学信息,2024,37(13):70-79.[doi:10.3969/j.issn.1006-1959.2024.13.014]
　Study on the Standardization of Clinical Application of Chinese Patent Medicine in the Adjuvant Treatment of Insulin Resistance in Hypertension.Study on the Standardization of Clinical Application of Chinese Patent Medicine in the Adjuvant Treatment of Insulin Resistance in Hypertension[J].Journal of Medical Information,2024,37(13):70-79.[doi:10.3969/j.issn.1006-1959.2024.13.014]
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中成药辅助治疗高血压病胰岛素抵抗临床应用规范化研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
70-79
栏目:
论著
出版日期:
2024-07-01

文章信息/Info

Title:
Study on the Standardization of Clinical Application of Chinese Patent Medicine in the Adjuvant Treatment of Insulin Resistance in Hypertension
文章编号:
1006-1959（2024）13-0070-10
作者:
陆 新; 龙 瑾
（广西国际壮医医院内科，广西 南宁 530001）
Author(s):
Study on the Standardization of Clinical Application of Chinese Patent Medicine in the Adjuvant Treatment of Insulin Resistance in Hypertension
(Department of Internal Medicine,Guangxi International Zhuang Hospital,Nanning 530001,Guangxi,China)
关键词:
高血压病; 胰岛素抵抗; GRADE系统; 中成药; 规范化应用
Keywords:
Hypertension; Insulin resistance; GRADE system; Chinese patent medicine; Standardized application
分类号:
R259
DOI:
10.3969/j.issn.1006-1959.2024.13.014
文献标志码:
A
摘要:
目的 构建中成药治疗高血压病胰岛素抵抗（IR）患者的临床问题。通过检索并系统评价临床研究证据，由此形成相应推荐意见，为中成药辅助治疗高血压病IR提供循证，并为下一步诊疗规范化应用提供依据。方法 检索中国知网数据库（CNKI）、维普数据库（VIP）、万方数据库（Wanfang Data）、美国国立医学图书馆（MEDLINE）、荷兰医学文摘数据库（EMBASE）、考克兰图书馆（The Cochrane Library）6个数据库，收集从建库至2022年12月31日有高血压病IR随机对照试验（RCT）原始文献。通过专家问卷调查法确定拟解决的问题，经解构运用PICO原则进行设置为关键、重要、次要及安全性结局指标。采用Meta方法对文献证据指标分析讨论，根据GRADE指南对证据质量评价分级，形成临床规范化应用推荐意见。结果 共纳入14篇文献系统评价，为11种中成药，包括44味中药，证据质量以中低质量为主，73个结局指标中，10个为中级质量，11个为低级质量，余为极低级质量。目前研究前证据显示，中成药辅助治疗高血压病IR可提高ISI、HDL-C，降低HOMA-IR、FINS、FPG、TC、TG（IB）、LDL-C。结论 依据中医辨证论治及证据分级，补肾益心片、防己黄芪胶囊为强推荐，血压平胶囊、加味二至丸、复方七芍降压片、降压定眩片、降压脉净冲剂、芪黄颗粒、针箭颗粒、血脂康胶囊、四泰片为弱推荐。
Abstract:
Objective To construct the clinical problems of Chinese patent medicine in the treatment of hypertension patients with insulin resistance (IR). By searching and systematically evaluating the clinical research evidence, the corresponding recommendations were formed, which provided evidence-based evidence for the adjuvant treatment of hypertension IR with Chinese patent medicine, and provided a basis for the standardized application of diagnosis and treatment in the next step.Methods Six databases, including CNKI, VIP, Wanfang Data, MEDLINE, EMBASE and The Cochrane Library, were searched to collect the original literature of randomized controlled trials (RCTs) on IR in hypertension from inception to December 31, 2022. Through the expert questionnaire survey method to determine the problem to be solved, the deconstruction of the use of PICO principles to set as the key, important, secondary and safety outcome of indicators. Meta-analysis was used to analyze and discuss the literature evidence indicators. According to the GRADE guidelines, the quality of evidence was evaluated and graded to form recommendations for clinical standardized application.Results A total of 14 systematic reviews were included, including 11 kinds of Chinese patent medicines, with 44 kinds of traditional Chinese medicines. The quality of evidence was mainly medium and low quality. Among the 73 outcome indicators, 10 were intermediate quality, 11 were low quality, and the rest were very low quality. The current evidence before the study showed that Chinese patent medicine adjuvant treatment of hypertension IR could increase ISI, HDL-C, reduce HOMA-IR, FINS, FPG, TC, TG (IB), LDL-C.Conclusion According to TCM syndrome differentiation and evidence classification, Bushen Yixin tablets and Fangji Huangqi capsules are strongly recommended, and Xueyapin gcapsules, Jiawei Erzhipills, Compound Qishao Jiangya tablets, Jiangya Dingxuan tablets, Jiangya Maijing granules, Qihuang granules, Zhenjian granules, Xuezhikang capsules and Sitai tablets are weakly recommended.

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更新日期/Last Update: 1900-01-01