[1]谢官莉,邓 力,廖江龙.小胶质细胞在脑缺血再灌注损伤中的作用机制研究进展[J].医学信息,2024,37(13):179-184.[doi:10.3969/j.issn.1006-1959.2024.13.039]
 Research Progress on the Mechanism of Microglia in Cerebral Ischemia-reperfusion Injury.Research Progress on the Mechanism of Microglia in Cerebral Ischemia-reperfusion Injury[J].Journal of Medical Information,2024,37(13):179-184.[doi:10.3969/j.issn.1006-1959.2024.13.039]
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小胶质细胞在脑缺血再灌注损伤中的作用机制研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
179-184
栏目:
综述
出版日期:
2024-07-01

文章信息/Info

Title:
Research Progress on the Mechanism of Microglia in Cerebral Ischemia-reperfusion Injury
文章编号:
1006-1959(2024)13-0179-06
作者:
谢官莉邓 力廖江龙
(1.云南中医药大学第二临床医学院,云南 昆明 650000;2.昆明市中医医院骨伤科,云南 昆明 650000)
Author(s):
Research Progress on the Mechanism of Microglia in Cerebral Ischemia-reperfusion Injury
(1.The Second Clinical Medical College,Yunnan University of Chinese Medicine,Kunming 650000,Yunnan,China; 2.Department of Orthopedics,Kunming Municipal Hospital of Traditional Chinese Medicine,Kunming 650000,Yunnan,China)
关键词:
脑缺血再灌注损伤小胶质细胞神经免疫
Keywords:
Cerebral ischemia-reperfusion injuryMicrogliaNeuroimmune
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2024.13.039
文献标志码:
A
摘要:
脑卒中是全球第三大死因,缺血性脑卒中是脑卒中的主要类型,目前治疗急性缺血性脑卒中最有效的手段是药物溶栓和机械取栓。脑血管再通后通常伴随着缺血再灌注损伤(IRI),探索IRI机制并提出有效的保护措施,既能尽早恢复脑组织的血流,又能减轻或防止IRI的发生,可对IRI患者的预后产生积极的影响。小胶质细胞是大脑的常住免疫细胞,在IRI后触发神经免疫反应,目前神经免疫反应介导的炎症已成为脑IRI治疗的靶点,然而,迄今为止,将有希望的实验结果转化为临床应用还未取得成功。部分原因可能是未考虑小胶质细胞形态和功能的动态变化,及与其他神经细胞的交互作用,片面的使用抗炎药物长期抑制小胶质细胞导致损伤恶化,故本文对小胶质细胞的功能变化情况及与其他神经细胞的交互作用进行综述,有望为小胶质细胞在脑IRI中的研究和实验室结果的临床转化提供参考。
Abstract:
Stroke is the third leading cause of death in the world. Ischemic stroke is the main type of stroke. At present, the most effective treatment for acute ischemic stroke is drug thrombolysis and mechanical thrombectomy. Cerebral vascular recanalization is usually accompanied by ischemia-reperfusion injury (IRI). Exploring the mechanism of IRI and proposing effective protective measures can not only restore the blood flow of brain tissue as soon as possible, but also reduce or prevent the occurrence of IRI, which has a positive impact on the prognosis of IRI patients. Microglia are resident immune cells in the brain, which trigger a neuroimmune response after IRI. At present, neuroimmune response-mediated inflammation has become a target for the treatment of cerebral IRI. However, the transformation of promising experimental results into clinical applications has not been successful. Part of the reason may be that the dynamic changes in the morphology and function of microglia and their interaction with other nerve cells are not considered. The one-sided use of anti-inflammatory drugs to inhibit microglia for a long time leads to deterioration of damage. Therefore, this article reviews the functional changes of microglia and their interaction with other nerve cells, which is expected to provide a reference for the study of microglia in brain IRI and the clinical transformation of laboratory results.

参考文献/References:

[1]GBD 2017 DALYs and HALE Collaborators.Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017[J].Lancet,2018,392(10159):1859-1922.[2]Zhou M,Wang H,Zeng X,et al.Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017[J].Lancet,2019,394(10204):1145-1158.[3]Tekle WG,Hassan AE,Jadhav AP,et al.Impact of Periprocedural and Technical Factors and Patient Characteristics on Revascularization and Outcome in the DAWN Trial[J].Stroke,2020,51(1):247-253.[4]Wu MY,Yiang GT,Liao WT,et al.Current Mechanistic Concepts in Ischemia and Reperfusion Injury[J].Cell Physiol Biochem,2018,46(4):1650-1667.[5]Mizuma A,You JS,Yenari MA.Targeting Reperfusion Injury in the Age of Mechanical Thrombectomy[J].Stroke,2018,49(7):1796-1802.[6]Shi K,Tian DC,Li ZG,et al.Global brain inflammation in stroke[J].Lancet Neurol,2019,18(11):1058-1066.[7]Zrzavy T,Machado-Santos J,Christine S,et al.Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts[J].Brain Pathol,2018,28(6):791-805.[8]Chen W,Zhang Y,Zhai X,et al.Microglial phagocytosis and regulatory mechanisms after stroke[J].J Cereb Blood Flow Metab,2022,42(9):1579-1596.[9]Yenari MA.Microglia, the brain’s double agent[J].J Cereb Blood Flow Metab,2020,40(1_suppl):S3-S5.[10]Augusto-Oliveira M,Arrifano GP,Lopes-Araújo A,et al.What Do Microglia Really Do in Healthy Adult Brain?[J].Cells,2019,8(10):1293.[11]Garaschuk O,Verkhratsky A.Physiology of Microglia[J].Methods Mol Biol,2019,2034:27-40.[12]Smolders SM,Kessels S,Vangansewinkel T,et al.Microglia: Brain cells on the move[J].Prog Neurobiol,2019,178:101612.[13]Prinz M,Jung S,Priller J.Microglia Biology: One Century of Evolving Concepts[J].Cell,2019,179(2):292-311.[14]Jia J,Yang L,Chen Y,et al.The Role of Microglial Phagocytosis in Ischemic Stroke[J].Front Immunol,2022,12:790201.[15]Teppo J,Vaikkinen A,Stratoulias V,et al.Molecular profile of the rat peri-infarct region four days after stroke: Study with MANF[J].Exp Neurol,2020,329:113288.[16]Xu S,Lu J,Shao A,et al.Glial Cells: Role of the Immune Response in Ischemic Stroke[J].Front Immunol,2020,11:294.[17]Tang Y,Le W.Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases[J].Mol Neurobiol,2016,53(2):1181-1194.[18]Butovsky O,Weiner HL.Microglial signatures and their role in health and disease[J].Nat Rev Neurosci,2018,19(10):622-635.[19]Raffaele S,Gelosa P,Bonfanti E,et al.Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis[J].Mol Ther,2021,29(4):1439-1458.[20]Mota M,Porrini V,Parrella E,et al.Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia[J].J Neuroinflammation,2020,17(1):361.[21]Li Q,Dai Z,Cao Y,et al.Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation[J].Biochem Biophys Res Commun,2019,513(2):479-485.[22]Lambertsen KL,Biber K,Finsen B.Inflammatory cytokines in experimental and human stroke[J].J Cereb Blood Flow Metab,2012,32(9):1677-1698.[23]Campbell BCV,Khatri P.Stroke[J].Lancet,2020,396(10244):129-142.[24]Hiu T,Farzampour Z,Paz JT,et al.Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target[J].Brain,2016,139(Pt 2):468-480.[25]Otxoa-de-Amezaga A,Miró-Mur F,Pedragosa J,et al.Microglial cell loss after ischemic stroke favors brain neutrophil accumulation[J].Acta Neuropathol,2019,137(2):321-341.[26]Ransohoff RM.A polarizing question: do M1 and M2 microglia exist?[J].Nat Neurosci,2016,19(8):987-991.[27]Lyu J,Xie D,Bhatia TN,et al.Microglial/Macrophage polarization and function in brain injury and repair after stroke[J].CNS Neurosci Ther,2021,27(5):515-527.[28]Ito D,Tanaka K,Suzuki S,et al.Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain[J].Stroke,2001,32(5):1208-1215.[29]Thiel A,Radlinska BA,Paquette C,et al.The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke[J].J Nucl Med,2010,51(9):1404-1412.[30]Ji K,Miyauchi J,Tsirka SE.Microglia: an active player in the regulation of synaptic activity[J].Neural Plast,2013,2013:627325.[31]Alawieh A,Langley EF,Tomlinson S.Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice[J].Sci Transl Med,2018,10(441):eaao6459.[32]Liu M,Xu Z,Wang L,et al.Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte[J].J Neuroinflammation,2020,17(1):270.[33]Joshi AU,Minhas PS,Liddelow SA,et al.Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration[J].Nat Neurosci,2019,22(10):1635-1648.[34]Allen NJ,Lyons DA.Glia as architects of central nervous system formation and function[J].Science,2018,362(6411):181-185.[35]Liddelow SA,Barres BA.Reactive Astrocytes: Production, Function, and Therapeutic Potential[J].Immunity,2017,46(6):957-967.[36]Vainchtein ID,Chin G,Cho FS,et al.Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development[J].Science,2018,359(6381):1269-1273.[37]Raffaele S,Fumagalli M.Dynamics of Microglia Activation in the Ischemic Brain: Implications for Myelin Repair and Functional Recovery[J].Front Cell Neurosci,2022,16:950819.[38]Li L,Harms KM,Ventura PB,et al.Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic[J].Glia,2010,58(13):1610-1619.[39]Xu J,Zhang L,Li M,et al.TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair[J].J Neuroinflammation,2023,20(1):50.[40]Miron VE,Boyd A,Zhao JW,et al.M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination[J].Nat Neurosci,2013,16(9):1211-1218.[41]Hamner MA,McDonough A,Gong DC,et al.Microglial depletion abolishes ischemic preconditioning in white matter[J].Glia,2022,70(4):661-674.[42]Puig B,Brenna S,Magnus T.Molecular Communication of a Dying Neuron in Stroke[J].Int J Mol Sci,2018,19(9):2834.

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更新日期/Last Update: 1900-01-01