[1]李振宏,施海龙,林思名,等.伴中央颞区棘波的儿童良性癫痫与 微量元素的关系研究[J].医学信息,2018,31(12):90-92.[doi:10.3969/j.issn.1006-1959.2018.12.027]
　LI Zhen-hong,SHI Hai-long,LIN Si-ming,et al.Study on the Relationship between Children's Benign Epilepsy and Trace Elements in the Central Temporal Spikes[J].Journal of Medical Information,2018,31(12):90-92.[doi:10.3969/j.issn.1006-1959.2018.12.027]
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伴中央颞区棘波的儿童良性癫痫与 微量元素的关系研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年12期
页码:
90-92
栏目:
论著
出版日期:
2018-06-15

文章信息/Info

Title:
Study on the Relationship between Children's Benign Epilepsy and Trace Elements in the Central Temporal Spikes
文章编号:
1006-1959（2018）12-0090-03
作者:
李振宏; 施海龙; 林思名; 祝鹏宇; 邓任辉
南昌大学附属赣州医院儿科，江西 赣州 341000
Author(s):
LI Zhen-hong; SHI Hai-long; LIN Si-ming; ZHU Peng-yu; DENG Ren-hui
Department of Pediatrics,Ganzhou Hospital,Nanchang University,Ganzhou 341000,Jiangxi,China
关键词:
中央颞区棘波; 癫痫; 儿童; 微量元素
Keywords:
Key words：Central temporal spikes; Epilepsy; Children; Trace elements
分类号:
R742.1
DOI:
10.3969/j.issn.1006-1959.2018.12.027
文献标志码:
A
摘要:
目的 分析伴中央颞区棘波的儿童良性癫痫与微量元素的相关性，探讨BECT的病因及发病机制。方法 选择在本院就诊的45例BECT患儿作为实验组，选择同一时间段来我院体检的儿童50例作为对照组。实验组儿童在首次惊厥发作24 h内给予抗癫痫药治疗前，对照组儿童在健康体检时，均抽取5 ml静脉血置于一次性使用生化采血管，采用BH5300S型钨舟原子吸收光谱仪检测全血微量元素浓度，分析比较两组儿童血清微量元素水平。结果 实验组血清锌含量为（6.80±1.93）mmol/L，低于对照组的（8.60±1.07）mmol/L，统计学意义显著（P＜0.01）。实验组血清铁含量为（4.20±1.32）mmol/L，低于对照组的（7.40±1.26） mmol/L，统计学意义显著（P＜0.01）。实验组血清铜含量为（15.80±2.10）mmol/L，与对照组（16.20±2.44）mmol/L比较，差异无统计学意义（P＞0.05）。结论 BECT患儿存在微量元素铁、锌减少，为临床工作者进一步研究BECT的病因及发病机制，提供了一个新的靶点。
Abstract:
Abstract：Objective To analyze the relationship between benign epilepsy and trace elements in children with central temporal spikes,and to explore the etiology and pathogenesis of BECT.Methods 45 BECT children in our hospital were selected as experimental group and 50 children in the same time period as control group.Children in the experimental group were treated with antiepileptic drugs within 24 hours after the first convulsion attack,and the control group children were collected 5 ml venous blood at the time of physical examination and placed in a single use of biochemical blood vessels.The concentration of trace elements in whole blood was determined by BH 5300S tungsten boat atomic absorption spectrometer,and the serum trace element levels of the two groups were analyzed and compared.Results The serum zinc concentration in the experimental group was(6.80±1.93)mmol/L,which was lower than that in the control group(8.60±1.07)mmol/L,with statistical significance(P<0.01).The serum iron content in the experimental group was(4.20±1.32)mmol/L,which was lower than that in the control group(7.40±1.26)mmol/L,with statistical significance(P<0.01).The serum copper level in the experimental group was(15.80±2.10)mmol/L,which was not statistically different from that in the control group(16.20±2.44)mmol/L(P>0.05).Conclusion There is a decrease in trace elements iron and zinc in children with BECT,which provides a new target for clinicians to further study the etiology and pathogenesis of BECT.

参考文献/References:

[1]Lee YJ,Hwang SK,Kwon S.The clinical spectrum of benign epilepsy with centro-temporal spikes:a challenge in categorization and predictability[J].J Epilepsy Res,2017,7(1):1-6.
[2]Blanco-Alvarez VM,Lopez-Moreno P,Soto-Rodriguez G,et al.Subacute zinc administration and L-NAME caused an increase of NO,zinc,lipoper oxidation,and caspase-3 during a cerebral hypoxia-ischemia process in the rat[J].Oxid Med Cell Longev,2013(12):550-560.
[3]Sun J,Xie C,Liu W,et al.The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats[J].Int J Mol Med,2012,30(4):739-746.
[4]Henshall DC,Engel T.Contribution of apoptosis-associated signaling pathways to epileptogenesis:lessons from Bcl-2 family knockouts[J].Front Cell Neurosci,2013,7(111):110.
[5]Faylon MP,Koltes DE,Spurlock DM.Regulation of lipid droplet-associated proteins following growth hormone administration and feed restriction in lactating Holstein cows[J].J Dairy Sci,2014,97(5):2847-2855.
[6]Ni H,Ren SY,Zhang LL,et al.Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus[J].Toxicol Lett,2013,217(2):162-169.
[7]田甜,赵东敬,倪宏,等.生酮饮食对新生期反复惊厥大鼠神经行为的影响及机制[J].中华行为医学与脑科学杂志,2013,22(10):865-868.
[8]徐丹凤,赵东敬,倪宏,等.生酮饮食对新生期反复惊厥大鼠远期神经行为及大脑皮层内锌离子流入蛋白7表达的影响[J].中华行为医学与脑科学杂志,2015,24(6):485-488.
[9]Nardou R,Ferrari DC,Ben-Ari Y.Mechanisms and effects of seizures in the immature brain[J].Semin Fetal Neonatal Med,2013,18(4):175-184.
[10]Grabrucker S,Jannetti L,Eckert M,et al.Zinc deficiency dysregulates the synaptic ProSAP Shank scaffold and might contribute to autism spectrum disorders[J].Brain,2014,137(1):137-152.

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更新日期/Last Update: 2018-06-15