[1]张 诚,丁建玲,麦麦提依明·托合提,等.P53、EGFR在胶质瘤组织中的表达及意义[J].医学信息,2020,33(07):94-96.[doi:10.3969/j.issn.1006-1959.2020.07.026]
　ZHANG Cheng,DING Jian-ling,McMatti Yiming Tohetti,et al.Expression and Significance of P53 and EGFR in Glioma Tissues[J].Medical Information,2020,33(07):94-96.[doi:10.3969/j.issn.1006-1959.2020.07.026]
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P53、EGFR在胶质瘤组织中的表达及意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年07期
页码:
94-96
栏目:
论著
出版日期:
2020-04-01

文章信息/Info

Title:
Expression and Significance of P53 and EGFR in Glioma Tissues
文章编号:
1006-1959（2020）07-0094-03
作者:
张 诚; 丁建玲; 麦麦提依明·托合提; 等
（新疆维吾尔自治区人民医院神经外科1，心外科2，新疆 乌鲁木齐 830000）
Author(s):
ZHANG Cheng; DING Jian-ling; McMatti Yiming Tohetti; et al
(Department of Neurosurgery1,Department of Cardiac Surgery2,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang,China)
关键词:
胶质瘤; P53; EGFR
Keywords:
Glioma; P53; EGFR
分类号:
R739.41
DOI:
10.3969/j.issn.1006-1959.2020.07.026
文献标志码:
A
摘要:
目的 评估P53、表皮样生长因子受体（EGFR）在胶质细胞瘤患者组织中的表达情况，分析二者与胶质瘤分级的相关性。方法 选取2018年1月~2019年7月新疆维吾尔自治区人民医院确诊胶质瘤患者组织标本40例作为实验组，选取同期脑外伤或高血压脑出血患者手术切除的正常脑组织15例为对照组，采用S-P免疫组化法检测实验组及对照组标本中的P53及EGFR在胶质瘤中的表达情况，分析P53及EGFR与胶质瘤分级的相关性。结果 实验组不同性别、年龄及肿瘤大小中P53、EGFR的表达比较，差异无统计学意义（P＞0.05）；实验组脑组织中P53及EGFR阳性表达率均高于对照组，差异有统计学意义（P＜0.05）；P53、EGFR在不同级别胶质瘤中阳性表达率均呈正相关（r=0.057、0.520，P=0.012、0.017）。脑胶质瘤组织中P53与EGFR表达无明显相关性（r=0.436，P=0.052）。结论 脑胶质瘤组织中P53、EGFR的表达可能与性别、年龄及肿瘤大小无关，P53、EGFR在不同级别胶质瘤中阳性表达率均较高，且胶质瘤级别越高，组织P53、EGFR阳性率越高，联合检测P53及EGFR可能作为胶质瘤分子病理诊断的新指标。
Abstract:
Objective To evaluate the expression of P53 and epidermoid growth factor receptor (EGFR) in the tissues of patients with glioma, and to analyze the correlation between the two and the grade of glioma.Methods From January 2018 to July 2019, 40 patients with glioma diagnosed in Xinjiang Uygur Autonomous Region were selected as the experimental group, and 15 normal brain tissues surgically removed from patients with brain trauma or hypertensive cerebral hemorrhage during the same period were selected as the control group. S-P immunohistochemical method was used to detect the expression of P53 and EGFR in gliomas in the experimental and control samples, and to analyze the correlation between P53 and EGFR and the grade of glioma.Results There was no statistically significant difference in the expression of P53 and EGFR in different genders, ages and tumor sizes in the experimental group (P>0.05); the positive expression rates of P53 and EGFR in the brain tissue of the experimental group were higher than that of the control group,the difference was statistically significant (P<0.05); The positive expression rates of P53 and EGFR in different grades of gliomas were positively correlated (r=0.057, 0.520, P=0.012, 0.017). There was no significant correlation between P53 and EGFR expression in glioma tissues (r=0.436, P=0.052).Conclusion The expression of P53 and EGFR in glioma tissue may not be related to gender, age and tumor size. The positive expression rates of P53 and EGFR in gliomas of different grades are higher, and the higher the grade of glioma, the tissue P53 and EGFR The higher the positive rate, the joint detection of P53 and EGFR may be used as a new indicator of molecular pathological diagnosis of glioma.

参考文献/References:

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更新日期/Last Update: 2020-04-01