[1]桑明敏,朱芳一,祝存奎,等.芪参益气滴丸联合美托洛尔治疗原发性高血压病合并慢性心衰的疗效[J].医学信息,2020,33(21):157-159.[doi:10.3969/j.issn.1006-1959.2020.21.049]
　SANG Ming-min,ZHU Fang-yi,ZHU Cun-kui,et al.Effect of Qishen Yiqi Dropping Pills and Metoprolol in the Treatment of Essential Hypertension with Chronic Heart Failure[J].Medical Information,2020,33(21):157-159.[doi:10.3969/j.issn.1006-1959.2020.21.049]
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芪参益气滴丸联合美托洛尔治疗原发性高血压病合并慢性心衰的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年21期
页码:
157-159
栏目:
中医中药
出版日期:
2020-11-01

文章信息/Info

Title:
Effect of Qishen Yiqi Dropping Pills and Metoprolol in the Treatment of Essential Hypertension with Chronic Heart Failure
文章编号:
1006-1959（2020）21-0157-03
作者:
桑明敏; 朱芳一; 祝存奎; 等
（青海省心脑血管病专科医院心律失常二科，青海 西宁 810000）
Author(s):
SANG Ming-min; ZHU Fang-yi; ZHU Cun-kui; et al
(Department of Arrhythmia,Subject Two,Qinghai Cardiovascular and Cerebrovascular Disease Hospital,Xining 810000,Qinghai,China)
关键词:
芪参益气滴丸; 美托洛尔; 原发性高血压病; 慢性心力衰竭; 心功能; 运动耐量
Keywords:
Qishen Yiqi dripping pills; Metoprolol; Essential hypertension; Chronic heart failure;  Heart function; Exercise tolerance
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2020.21.049
文献标志码:
A
摘要:
目的 评价芪参益气滴丸联合美托洛尔治疗原发性高血压病合并慢性心衰（CHF）的临床疗效。方法 收集2019年1~12月于我科就诊的100例原发性高血压病合并CHF患者作为研究对象，按照治疗方案分为对照组和观察组，各50例；对照组给予美托洛尔治疗，观察组在对照组基础上联合芪参益气滴丸治疗。采用Yaeger心肺功能测试系统评估患者运动耐量，治疗3个月后，比较两组临床疗效、心功能指标、运动耐量及不良反应发生情况。结果 观察组总有效率高于对照组（94.00% vs 80.00%），差异有统计学意义（P＜0.05）；观察组左室舒张末期内径（LVEDD）、E峰流速/A峰流速（E/A）、左室射血分数（LVEF）、运动时间、最大心率及最大摄氧量改善均优于对照组，差异有统计学意义（P＜0.05）；两组不良反应发生率比较（8.00% vs 16.00%），差异无统计学意义（P＞0.05）。结论 芪参益气滴丸联合美托洛尔在原发性高血压病合并CHF患者的临床效果良好，能够有效改善患者心功能和运动耐量，且不增加不良反应，值得应用。
Abstract:
Objective To evaluate the clinical efficacy of Qishen Yiqi Dripping Pills combined with Metoprolol in the treatment of essential hypertension with chronic heart failure (CHF).Methods A total of 100 patients with primary hypertension and CHF who were treated in our department from January to December 2019 were collected as the research object. According to the treatment plan, they were divided into a control group and an observation group, each with 50 cases; the control group was given metoprolol for treatment, the observation group was combined with Qishen Yiqi dripping pills on the basis of the control group. The Yaeger cardiopulmonary function test system was used to assess the patient’s exercise tolerance. After 3 months of treatment, the clinical efficacy, cardiac function indicators, exercise tolerance and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (94.00% vs 80.00%),the difference was statistically significant (P＜0.05); the observation group left ventricular end diastolic diameter (LVEDD), peak E flow rate/peak flow rate A (E/A ),left ventricular ejection fraction (LVEF), exercise time, maximum heart rate and maximum oxygen uptake were better than the control group, the difference was statistically significant (P<0.05); the incidence of adverse reactions between the two groups was compared (8.00% vs. 16.00%), the difference was not statistically significant (P>0.05).Conclusion Qishen Yiqi dripping pill combined with metoprolol had a good clinical effect in patients with essential hypertension complicated with CHF. It could effectively improve the patient’s cardiac function and exercise tolerance without increasing adverse reactions. It was worthy of application.

参考文献/References:

[1]周坤,郑遵荣,周玉珍,等.高血压五项激素水平与原发性高血压的相关性研究[J].中国医师进修杂志,2020,43(3):231-235.[2]Nina A,Fatimeh H.Spectrophotometric method for the determination of amlodipine besylate in pure and dosage forms using 7,7,8,8-tetracyanoquinodimethane and tetracyanoethylene[J].Bulletin of Faculty of Pharmacy,Cairo University,2014,52(1):109-114.[3]刘敏,孙波.拉贝洛尔对老年女性慢性心力衰竭患者神经内分泌激素激活的影响[J].中国老年学杂志,2016,36(22):5601-5602. [4]吉训恋,陆士娟.脑心通胶囊联合美托洛尔对老年缺血性心肌病心力衰竭患者的临床疗效[J].中成药,2020,42(1):254-256. [5]张杰,赖润民,鞠建庆,等.芪参益气滴丸治疗射血分数保留心力衰竭的网络药理学研究[J].中国医药导报,2020,17(1):21-24.[6]赵文君,郭艺芳.国内外新版高血压指南要点与解读[J].中国心血管杂志,2019,24(2):99-101. [7]中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.慢性心力衰竭基层诊疗指南(2019年)[J].中华全科医师杂志,2019,18(10):936-947.[8]Fritz B.Relevant effects of beta sub 1, sub-adrenoceptor autoantibodies in chronic heart failure[J].Frontiers in Bioscience,2018,23(11):2146-2156.[9]卢乃棉,周建松.老年慢性心力衰竭患者血清D-二聚体含量与心力衰竭程度关系的临床研究[J].国际老年医学杂志,2019,40(6):344-346.[10]许笑雯,李益萍,阮小芬,等.慢性心力衰竭与淋巴细胞和细胞因子相关性的研究进展[J].中国医药导报,2019,16(20):41-44.[11]董蕾,田颖,刘肆仁,等.沙库巴曲缬沙坦钠片对慢性心力衰竭患者的疗效及对神经内分泌激素活性的影响[J].中国医药,2019,14(5):655-658.[12]范艳梅,刘佰学.沙库巴曲缬沙坦联合酒石酸美托洛尔对老年慢性心力衰竭患者的应用效果[J].中国医学前沿杂志（电子版）,2019,11(11):120-124.[13]陈良平.美托洛尔用于慢性充血性心力衰竭的效果分析[J].中国基层医药,2019,26(20):2437-2441.[14]夏勇,张建卿,王少霞,等.沙库巴曲缬沙坦联合琥珀酸美托洛尔缓释片治疗冠状动脉粥样硬化性心脏病并慢性心力衰竭的效果观察[J].首都医科大学学报,2020,41(1):113-118. [15]苏凤婷,严沛元,夏清.美托洛尔在心房纤颤合并慢性心力衰竭治疗中的应用效果[J].中国基层医药,2019,26(20):2442-2445.[16]彭玉霞,卢桂林,张斌霞.中医药治疗慢性心力衰竭的研究进展[J].中国中医急症,2020,29(2):373-376.[17]王曙光,王霞.芪参益气滴丸联合尿激酶对心肌梗死患者血脂水平和左心室功能的影响[J].药物评价研究,2019,42(7):1403-1406.[18]张凯旋,耿巍,姜一鸣,等.芪参益气滴丸对射血分数保留心力衰竭的疗效观察[J].临床荟萃,2019,34(11):995-998. [19]陈伟国,朱萧玲,常盼,等.芪参益气滴丸对急性心肌梗死PCI术后患者血清学指标及预后的影响[J].陕西中医,2020,41(1):20-23.

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更新日期/Last Update: 1900-01-01