[1]李贝贝,毋浪平,姚亚红.近十年国内帕金森病研究热点与趋势的可视化分析[J].医学信息,2021,34(12):15-18.[doi:10.3969/j.issn.1006-1959.2021.12.005]
　LI Bei-bei,WU Lang-ping,YAO Ya-hong.Visual Analysis of Domestic Parkinson’s Disease Research Hotspots and Trends in the Past Ten Years[J].Medical Information,2021,34(12):15-18.[doi:10.3969/j.issn.1006-1959.2021.12.005]
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近十年国内帕金森病研究热点与趋势的可视化分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年12期
页码:
15-18
栏目:
出版日期:
2021-06-15

文章信息/Info

Title:
Visual Analysis of Domestic Parkinson’s Disease Research Hotspots and Trends in the Past Ten Years
文章编号:
1006-1959（2021）12-0015-04
作者:
李贝贝; 毋浪平; 姚亚红
（西安交通大学第一附属医院东院中医康复科，陕西 西安 710089）
Author(s):
LI Bei-bei; WU Lang-ping; YAO Ya-hong
(Department of Traditional Chinese Medicine Rehabilitation,Dongyuan Hospital,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710089,Shaanxi,China)
关键词:
帕金森病; 小胶质细胞; 神经炎症; 知识图谱
Keywords:
Parkinson’s disease; Microglia; Neuroinflammation; Knowledge map
分类号:
R742.5；G250.73
DOI:
10.3969/j.issn.1006-1959.2021.12.005
文献标志码:
A
摘要:
目的 分析国内机构有关帕金森病（PD）研究的特征并预测热点与趋势。方法 基于Web of Science核心合集数据库，检索2010年~2020年国内发表PD相关研究的SCI-Expanded文献，应用Graphpad prism呈现年发文量并预测趋势，CiteSpace分析期刊、文章、机构、共被引文献、突发词并绘制知识图谱。结果 共纳入5180篇文献，PD发文量在近10年里持续增长；其中NEUROSCIENCE LETTERS发文量最多，首都医科大学是发文量最多的机构，与国内PD研究合作最多的国家/地区是美国；PD研究主题包含神经保护、家族性PD、多巴胺能神经元、PD患者、二价金属转运体及非运动症状；2018年~2020年的突发词为小胶质细胞、神经炎症与临床症状。结论 目前国内PD研究热点包含氧化应激、凋亡及铁沉积，神经变性与保护，α-突触核蛋白，致病基因及非运动症状。此外，小胶质细胞、神经炎症及临床症状研究是PD研究领域的趋势。
Abstract:
Objective To analyze the characteristics of Parkinson’s disease (PD) research in domestic institutions and predict hot spots and trends.Methods Based on the core collection of Web of Science database, retrieved domestic SCI-Expanded literatures published in PD related research from 2010 to 2020.Graphpad prism is used to present the annual publication volume and forecast trends. CiteSpace analyzes journals, articles, institutions, co-cited documents, sudden words and draws a knowledge map.Results A total of 5180 articles were included, and the number of PD publications has continued to increase in the past 10 years;Among them, NEUROSCIENCE LETTERS has published the most papers,Capital Medical University is the institution with the most papers, and the country/region with the most domestic PD research cooperation is the United States;PD research topics include neuroprotection, familial PD, dopaminergic neurons, PD patients, divalent metal transporters and non-motor symptoms;The sudden words from 2018 to 2020 are microglia, neuroinflammation and clinical symptoms.Conclusion The current domestic research hotspots of PD include oxidative stress, apoptosis and iron deposition, neurodegeneration and protection, α-synuclein, pathogenic genes and non-motor symptoms. In addition, the research of microglia, neuroinflammation and clinical symptoms is a trend in the field of PD research.

参考文献/References:

[1]Simon DK,Tanner CM,Brundin P.Parkinson Disease Epidemiology,Pathology,Genetics,and Pathophysiology[J].Clin Geriatr Med,2020,36(1):1-12. [2]Homayoun H.Parkinson Disease[J].Ann Intern Med,2018,169(5):C33-C48. [3]Poewe W,Seppi K,Tanner CM,et al.Parkinson disease[J].Nat Rev Dis Primers,2017(3):17013. [4]Dorsey ER,Constantinescu R,Thompson JP,et al.Projected number of people with Parkinson disease in the most populous nations,2005 through 2030[J].Neurology,2007,68(5):384-386. [5]Lee HP,Zhu X,Liu G,et al.Divalent metal transporter,iron,and Parkinson’s disease:a pathological relationship[J].Cell Res,2010,20(4):397-399. [6]Ingrassia R,Garavaglia B,Memo M.DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration[J].Front Neurosci,2019(13):575. [7]Deng H,Wang P,Jankovic J.The genetics of Parkinson disease[J].Ageing Res Rev,2018(42):72-85. [8]Kalinderi K,Bostantjopoulou S,Fidani L.The genetic background of Parkinson’s disease:current progress and future prospects[J].Acta Neurol Scand,2016,134(5):314-326. [9]Schapira A,Chaudhuri KR,Jenner P.Non-motor features of Parkinson disease[J].Nat Rev Neurosci,2017,18(7):435-450. [10]Chase BA,Markopoulou K.Olfactory Dysfunction in Familial and Sporadic Parkinson’s Disease[J].Front Neurol,2020(11):447. [11]Sommer A,Marxreiter F, Krach F,et al.Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease[J].Cell Stem Cell,2018,23(1):123-131. [12]Barba C,Alexopoulos H.Parkinsonism in autoimmune diseases[J].Int Rev Neurobiol,2019(149):419-452. [13]Tan EK,Chao YX,West A,et al.Parkinson disease and the immune system-associations,mechanisms and therapeutics[J].Nat Rev Neurol,2020,16(6):303-318. [14]Hirsch EC,Standaert DG.Ten Unsolved Questions About Neuroinflammation in Parkinson’s Disease[J].Mov Disord,2021,36(1):16-24. [15]Kustrimovic N,Comi C,Magistrelli L,et al.Parkinson’s disease patients have a complex phenotypic and functional Th1 bias:cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naive and drug-treated patients[J].J Neuroinflammation,2018,15(1):205. [16]Yang L,Mao K,Yu H,et al.Neuroinflammatory Responses and Parkinson’ Disease:Pathogenic Mechanisms and Therapeutic Targets[J].J Neuroimmune Pharmacol,2020,15(4):830-837. [17]Ma A,Lau KK,Thyagarajan D.Voice changes in Parkinson’s disease:What are they telling us[J].J Clin Neurosci,2020(72):1-7. [18]Umemoto G,Furuya H.Management of Dysphagia in Patients with Parkinson’s Disease and Related Disorders[J].Intern Med,2020,59(1):7-14.

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更新日期/Last Update: 1900-01-01