[1]李 娟,胡 欣,张小妹.米非司酮联合血府逐瘀汤治疗子宫腺肌病的临床观察[J].医学信息,2021,34(23):168-171.[doi:10.3969/j.issn.1006-1959.2021.23.051]
 LI Juan,HU Xin,ZHANG Xiao-mei.Clinical Observation of Mifepristone Combined with Xuefu Zhuyu Decoction in the Treatment of Adenomyosis[J].Medical Information,2021,34(23):168-171.[doi:10.3969/j.issn.1006-1959.2021.23.051]
点击复制

米非司酮联合血府逐瘀汤治疗子宫腺肌病的临床观察()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
168-171
栏目:
中医中药
出版日期:
2021-12-01

文章信息/Info

Title:
Clinical Observation of Mifepristone Combined with Xuefu Zhuyu Decoction in the Treatment of Adenomyosis
文章编号:
1006-1959(2021)23-0168-04
作者:
李 娟胡 欣张小妹
(南昌市洪都中医院妇科,江西 南昌 330000)
Author(s):
LI JuanHU XinZHANG Xiao-mei
(Department of Gynecology,Nanchang Hongdu Hospital of Traditional Chinese Medicine,Nanchang 330000,Jiangxi,China)
关键词:
子宫腺肌病米非司酮血府逐瘀汤子宫体积性激素CA125
Keywords:
Adenomyosis of uterusMifepristoneXuefu Zhuyu decoctionUterine volumeSex hormoneCA125
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2021.23.051
文献标志码:
A
摘要:
目的 研究米非司酮联合血府逐瘀汤治疗子宫腺肌病的临床效果。方法 选取2020年1月-2021年6月南昌市洪都中医院妇科收治的60例子宫腺肌病患者,采用随机数字表分为观察组和对照组,各30例。对照组应用米非司酮治疗,观察组在对照组治疗基础上加血府逐瘀汤口服治疗,比较两组临床疗效、痛经情况(持续天数、疼痛程度)、经期症状积分(行经量、月经颜色)、性激素水平[促卵泡素(FSH)、促黄体生成素(LH)、雌二醇(E2)]、糖类抗原125(CA125)、子宫体积、不良反应。结果 观察组治疗有效率高于对照组(P<0.05);治疗后,观察组痛经持续天数短于对照组,痛经程度、行经量及月经颜色评分均小于对照组(P<0.05);治疗后,两组FSH、LH、E2水平低于治疗前,且观察组低于对照组(P<0.05);观察组CA125低于对照组,子宫体积小于对照组(P<0.05);两组心、肝、肾功能及血、尿、粪常规等指标均无异常,无严重不良反应发生。结论 米非司酮联合血府逐瘀汤治疗子宫腺肌病疗效确切,可改善患者经期症状及内分泌情况,降低血清肿瘤标志物水平,缩小子宫体积,且安全性高。
Abstract:
Objective To study the clinical effect of mifepristone combined with Xuefu Zhuyu decoction in the treatment of adenomyosis.Methods A total of 60 patients with adenomyosis admitted to the Department of Gynecology, Nanchang Hongdu Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were selected and divided into observation group and control group by random number table, with 30 cases in each group. The control group was treated with mifepristone, and the observation group was treated with Xuefu Zhuyu decoction on the basis of the treatment of the control group. The clinical efficacy, dysmenorrhea (duration, pain degree), menstrual symptom score (menstrual volume, menstrual color ), the level of sex hormone [follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2)], carbohydrate antigen 125 (CA125), uterine volume, and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). After treatment, the duration of dysmenorrhea in the observation group was shorter than that in the control group, and the scores of dysmenorrhea, menstrual volume and menstrual color were lower than those in the control group (P<0.05). After treatment, the levels of FSH, LH and E2 in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). CA125 in the observation group was lower than that in the control group, and the uterine volume was smaller than that in the control group (P<0.05). There were no abnormalities in the heart, liver, kidney function, blood, urine, stool routine and other indicators in the two groups, and no serious adverse reactions occurred.Conclusion Mifepristone combined with Xuefu Zhuyu decoction has a definite effect in the treatment of adenomyosis, which can improve menstrual symptoms and endocrine conditions, reduce serum tumor marker levels, reduce uterine volume, and has high safety.

参考文献/References:

[1]曹瑾琼.中西医结合治疗气滞血瘀型子宫腺肌病伴痛经疗效观察[J].中国民族民间医药,2018,27(6):65-67.[2]Guo Y,Duan H,Cheng J,et al.Gonadotrophin-releasing hormone agonist combined with high-intensity focused ultrasound ablation for adenomyosis: a clinical study[J].BJOG,2017,124(3):7-11.[3]裴凤霞,徐贞淑,严丽慧.左炔诺孕酮宫内节育系统联合少腹逐瘀汤加减治疗子宫腺肌病痛经临床研究[J].新中医,2020,52(8):55-57.[4]谭忠伦.血府逐瘀汤联合米非司酮治疗中老年子宫肌瘤的应用疗效及对相关指标的影响[J].中国医药导刊,2019,21(10):583-588.[5]葛丽萍.不同剂量米非司酮治疗子宫腺肌病238例临床观察[J].中国医药导刊,2019,21(7):417-420.[6]李潇.中医综合疗法治疗子宫腺肌病痛经的临床研究[J].中医药学报,2016,44(4):45-47.[7]余娜妮,陈星星.米非司酮联合温经汤加减对子宫腺肌病临床疗效观察[J].实用医技杂志,2019,26(2):214-215.[8]吴佩佩.少腹逐瘀汤加减对子宫腺肌病痛经的治疗作用探讨[J].海峡药学,2019,31(1):115-116.[9]中华医学会妇产科学分会子宫内膜异位症协作组.子宫内膜异位症的诊治指南[J].中华妇产科杂志,2015,50(3):161-169.[10]赵文聪.米非司酮联合左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床研究[J].青岛医药卫生,2018,50(6):440-443.[11]周文娟,桂涛,邹建龙,等.子宫腺肌病患者中医证候与体质分布情况及两者相关性多中心研究[J].中国中医基础医学杂志,2018,24(11):1574-1576,1627.[12]Hashimoto A,Iriyama T,Sayama S,et al.Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition[J].J Matern Fetal Neonatal Med,2018,31(3):364-369.[13]芦玉香.血府逐瘀汤联合米非司酮对异位妊娠患者血清β-HCG及孕酮水平的影响[J].内蒙古中医药,2018,37(8):67-68.[14]谷少华.桂枝茯苓汤加减联合米非司酮治疗子宫腺肌病伴痛经疗效分析[J].实用中医药杂志,2020,36(4):461-462.[15]吴静,刘甜甜,张志华,等.卵巢型子宫内膜异位症的治疗研究[J].实用妇科内分泌电子杂志,2019,6(17):19-21.[16]曾玉燕,李坤寅,关永格.加味芍药甘草汤及含药血清对子宫腺肌病E2、ER及芳香化酶P450的影响[J].北京中医药大学学报,2017,40(9):722-728.[17]白亚鹭,王永玲.少腹逐瘀汤治疗寒凝血瘀型子宫腺肌病痛经的临床研究[J].内蒙古中医药,2017,36(16):11.[18]唐密.血府逐瘀汤加减治疗子宫腺肌病30例疗效观察[J].中医药导报,2017,23(14):103-104.[19]刘震.少腹逐瘀汤加减在子宫腺肌病痛经治疗中的疗效[J].中国实用医药,2019,14(19):131-133.[20]葛江风,詹尧平.小剂量米非司酮配合中药治疗子宫腺肌病的临床观察[J].中国基层医药,2017,24(8):1161-1164.[21]张丽华,邱瑞雪,宋立山.中西药联合在子宫腺肌病的应用[J].中国继续医学教育,2017,9(5):186-188.[22]韩凤英.采用中西医结合治疗子宫腺肌病的疗效观察[J].实用中西医结合临床,2016,16(8):27-29.[23]石娜.血府逐瘀汤联合米非司酮治疗子宫内膜异位症的效果[J].临床医学,2021,41(7):119-121.[24]Carrarelli P,Yen CF,Funghi L,et al.Expression of Inflammatory and Neurogenic Mediators in Adenomyosis[J].Reprod Sci,2017,24(3):369-375.[25]李彦珍.血府逐瘀汤联合米非司酮治疗子宫肌瘤的疗效及安全性[J].光明中医,2018,33(20):3060-3061.[26]黄昕,廉伟.血府逐瘀汤联合米非司酮治疗异位妊娠疗效研究[J].陕西中医,2020,41(10):1376-1378.

相似文献/References:

[1]翟 蓓,周 洋,周 薇,等.超声检查、磁共振及血清CA125测定诊断 子宫腺肌病的临床评价[J].医学信息,2018,31(11):154.[doi:10.3969/j.issn.1006-1959.2018.11.050]
 ZHAI Bei,ZHOU Yang,ZHOU Wei,et al.Clinical Evaluation of Ultrasonography,Magnetic Resonance Imaging and Serum CA125 in Diagnosis of Adenomyosis[J].Medical Information,2018,31(23):154.[doi:10.3969/j.issn.1006-1959.2018.11.050]
[2]周 鑫,王 明,魏 宏.药物流产终止乙肝病毒感染患者10~14周妊娠的 安全性及有效性分析[J].医学信息,2018,31(12):112.[doi:10.3969/j.issn.1006-1959.2018.12.035]
 ZHOU Xin,WANG Ming,WEI Hong.Analysis of Safety and Effectiveness of Stopping Hepatitis B Virus Infection in 10 to 14 Weeks of Pregnancy by Drug Abortion[J].Medical Information,2018,31(23):112.[doi:10.3969/j.issn.1006-1959.2018.12.035]
[3]杨 霞,陈亚兰.左炔诺孕酮宫内缓释系统治疗子宫腺肌病的临床观察[J].医学信息,2019,32(14):117.[doi:10.3969/j.issn.1006-1959.2019.14.037]
 YANG Xia,CHEN Ya-lan.Clinical Observation of Levonorgestrel Intrauterine Sustained Release System in the Treatment of Adenomyosis[J].Medical Information,2019,32(23):117.[doi:10.3969/j.issn.1006-1959.2019.14.037]
[4]张 勇.阴道放置米索前列醇在终止6~10周妊娠负压吸宫术前的应用[J].医学信息,2019,32(24):143.[doi:10.3969/j.issn.1006-1959.2019.24.051]
 ZHANG Yong.Application of Vaginal Misoprostol Before Termination of Negative Pressure Uterine Aspiration with 6 to 10 Weeks[J].Medical Information,2019,32(23):143.[doi:10.3969/j.issn.1006-1959.2019.24.051]
[5]李 丽.米非司酮与乳酸依沙吖啶联合治疗中晚期妊娠引产的临床疗效[J].医学信息,2019,32(24):159.[doi:10.3969/j.issn.1006-1959.2019.24.058]
 LI Li.Clinical Efficacy of Mifepristone Combined with Ethacridine Lactate in the Induction of Labor in Mid-to-late Pregnancy[J].Medical Information,2019,32(23):159.[doi:10.3969/j.issn.1006-1959.2019.24.058]
[6]张晓丽,李晶晶,谭广萍,等.腹腔镜病灶切除联合序贯使用亮丙瑞林及优思明在子宫腺肌病中的应用[J].医学信息,2020,33(03):102.[doi:10.3969/j.issn.1006-1959.2020.03.029]
 ZHANG Xiao-li,LI Jing-jing,TAN Guang-ping,et al.The Effect of Sequential Drug Treatment on Adenomyosis After Laparoscopic Focal Resection[J].Medical Information,2020,33(23):102.[doi:10.3969/j.issn.1006-1959.2020.03.029]
[7]范叶柏,宫 雪,杨晓晨.米非司酮联合甲氨蝶呤与单纯甲氨蝶呤治疗宫外孕的临床安全性和有效性比较[J].医学信息,2021,34(13):170.[doi:10.3969/j.issn.1006-1959.2021.13.047]
 FAN Ye-bai,GONG Xue,YANG Xiao-chen.Comparison of the Clinical Safety and Effectiveness of Mifepristone Combined with Methotrexate and Methotrexate Alone in the Treatment of Ectopic Pregnancy[J].Medical Information,2021,34(23):170.[doi:10.3969/j.issn.1006-1959.2021.13.047]
[8]张东霞.米非司酮在子宫内膜异位症患者腹腔镜手术中的应用研究[J].医学信息,2021,34(16):175.[doi:10.3969/j.issn.1006-1959.2021.16.050]
 ZHANG Dong-xia.Application of Mifepristone in Laparoscopic Surgery in Patients with Endometriosis[J].Medical Information,2021,34(23):175.[doi:10.3969/j.issn.1006-1959.2021.16.050]
[9]彭琼琳,黄 敏.超声消融结合中药治疗子宫腺肌病继发性痛经的效果[J].医学信息,2021,34(17):157.[doi:10.3969/j.issn.1006-1959.2021.17.042]
 PENG Qiong-lin,HUANG Min.The Effect of Ultrasonic Ablation Combined with Traditional Chinese Medicine in the Treatment of Secondary Dysmenorrhea Caused by Adenomyosis[J].Medical Information,2021,34(23):157.[doi:10.3969/j.issn.1006-1959.2021.17.042]
[10]刘细风.甲氨蝶呤联合米非司酮治疗不同β-hCG水平宫外孕患者的效果[J].医学信息,2021,34(24):138.[doi:10.3969/j.issn.1006-1959.2021.24.035]
 LIU Xi-feng.Effect of Methotrexate Combined with Mifepristone in the Treatment of Ectopic Pregnancy with Different β-hCG Levels[J].Medical Information,2021,34(23):138.[doi:10.3969/j.issn.1006-1959.2021.24.035]

更新日期/Last Update: 1900-01-01