[1]何显阳,刘方文,黄云英,等.多西他赛联合顺铂新辅助化疗对非小细胞肺癌治疗中相关肿瘤标记物的影响[J].医学信息,2021,34(23):165-167.[doi:10.3969/j.issn.1006-1959.2021.23.050]
 HE Xian-yang,LIU Fang-wen,HUANG Yun-ying,et al.Effect of Docetaxel Combined with Cisplatin Neoadjuvant Chemotherapy on Related Tumor Markers in the Treatment of Non-small Cell Lung Cancer[J].Medical Information,2021,34(23):165-167.[doi:10.3969/j.issn.1006-1959.2021.23.050]
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多西他赛联合顺铂新辅助化疗对非小细胞肺癌治疗中相关肿瘤标记物的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
165-167
栏目:
药物与临床
出版日期:
2021-12-01

文章信息/Info

Title:
Effect of Docetaxel Combined with Cisplatin Neoadjuvant Chemotherapy on Related Tumor Markers in the Treatment of Non-small Cell Lung Cancer
文章编号:
1006-1959(2021)23-0165-03
作者:
何显阳刘方文黄云英
(上犹县人民医院肿瘤科,江西 上犹 341200)
Author(s):
HE Xian-yangLIU Fang-wenHUANG Yun-yinget al.
(Department of Oncology,Shangyou County People’s Hospital,Shangyou 341200,Jiangxi,China)
关键词:
非小细胞肺癌多西他赛顺铂新辅助化疗肿瘤标记物
Keywords:
Non-small cell lung cancerDocetaxelCisplatinNeoadjuvant chemotherapyTumor markers
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2021.23.050
文献标志码:
A
摘要:
目的 研究非小细胞肺癌治疗中多西他赛联合顺铂新辅助化疗对相关肿瘤标记物的影响。方法 选取2020年1月-2021年1月我院收治的非小细胞肺癌患者76例,随机分为对照组和观察组,各38例。对照组采用多西他赛进行术前化疗,观察组采用多西他赛联合顺铂进行新辅助化疗,比较两组临床治疗总缓解率、生活质量(KPS评分)、肿瘤标记物水平、毒副反应发生率和无进展生存期。结果 观察组治疗总缓解率为84.21%,高于对照组的71.05%(P<0.05);治疗后,两组KPS评分均高于治疗前,且观察组高于对照组(P<0.05),两组SCC、CEA、CYFRA21-1均低于治疗前,且观察组低于对照组(P<0.05);两组毒副反应总发生率比较,差异无统计学意义(P>0.05);随访6个月,观察组平均无进展生存期长于对照组(P<0.05)。结论 多西他赛联合顺铂新辅助化疗治疗非小细胞肺癌,可提高短期治疗总缓解率,降低肿瘤标志物水平,提高患者生活质量水平,延长患者无进展生存期,且不会增加显著不良反应,是一种安全、有效的新辅助化疗方案。
Abstract:
Objective To study the effect of docetaxel combined with cisplatin neoadjuvant chemotherapy on related tumor markers in the treatment of non-small cell lung cancer.Methods A total of 76 patients with non-small cell lung cancer admitted to our hospital from January 2020 to January 2021 were randomly divided into control group and observation group, with 38 cases in each group. The control group was treated with docetaxel for preoperative chemotherapy, and the observation group was treated with docetaxel combined with cisplatin for neoadjuvant chemotherapy. The total remission rate, quality of life (KPS score), tumor marker level, incidence of adverse reactions and progression-free survival were compared between the two groups.Results The total remission rate of the observation group was 84.21%, which was higher than 71.05% of the control group (P<0.05). After treatment, the KPS scores of the two groups were higher than those before treatment, and the observation group was higher than the control group (P<0.05); SCC, CEA and CYFRA21-1 in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). After 6 months of follow-up, the average progression-free survival of the observation group was longer than that of the control group (P<0.05).Conclusion Docetaxel combined with cisplatin neoadjuvant chemotherapy in the treatment of non-small cell lung cancer can improve the total remission rate of short-term treatment, reduce the level of tumor markers, improve the quality of life of patients, prolong the progression-free survival of patients, and do not increase the significant adverse reactions. It is a safe and effective neoadjuvant chemotherapy scheme.

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更新日期/Last Update: 1900-01-01