[1]栾 涛,王帅颖,高永军,等.低温对缺血性脑卒中神经保护的作用机制研究[J].医学信息,2022,35(01):54-58.[doi:10.3969/j.issn.1006-1959.2022.01.013]
 LUAN Tao,WANG Shuai-ying,GAO Yong-jun,et al.Mechanism of Hypothermia on Neuroprotection in Ischemic Stroke[J].Medical Information,2022,35(01):54-58.[doi:10.3969/j.issn.1006-1959.2022.01.013]
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低温对缺血性脑卒中神经保护的作用机制研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年01期
页码:
54-58
栏目:
综述
出版日期:
2022-01-01

文章信息/Info

Title:
Mechanism of Hypothermia on Neuroprotection in Ischemic Stroke
文章编号:
1006-1959(2022)01-0054-05
作者:
栾 涛王帅颖高永军
(1.昆明医科大学第二附属医院神经外科,云南 昆明 650000;2.武汉市新洲区人民医院康复科,湖北 武汉 431400)
Author(s):
LUAN TaoWANG Shuai-yingGAO Yong-junet al.
(1.Department of Neurosurgery,the Second Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan,China;2.Department of Rehabilitation,Wuhan Xinzhou District People’s Hospital,Wuhan 431400,Hubei,China)
关键词:
低温缺血性脑卒中PI3K/AKT信号通路脑保护
Keywords:
HypothermiaIschemic strokePI3K/AKT signaling pathwayCerebral protection
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.01.013
文献标志码:
A
摘要:
缺血性脑卒中是指由脑的供血动脉狭窄或闭塞、脑供血不足导致的脑组织坏死的疾病。研究发现,对缺血性脑卒中患者使用低温治疗有助于其预后。在大脑急性、亚急性和慢性缺血阶段,低温会从兴奋毒性、细胞凋亡、炎症、自由基产生、血液流动、新陈代谢和血脑屏障等方面影响大脑,因此本文就低温对缺血性脑卒中神经保护的作用机制进行综述,以期为缺血性脑卒中治疗提供新思路。
Abstract:
Ischemic stroke is a general term for brain tissue necrosis caused by narrowing or occlusion of the blood supplying arteries to the brain and insufficient blood supply to the brain. Studies have found that the use of hypothermia in patients with ischemic stroke helps their prognosis. In the acute, subacute and chronic ischemic phases of the brain, hypothermia affects the brain in terms of excitotoxicity, apoptosis, inflammation, free radical production, blood flow, metabolism and blood-brain barrier, therefore, this paper reviews the mechanism of the neuroprotective effect of hypothermia in ischemic stroke with the aim of providing new ideas for the treatment of ischemic stroke.

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更新日期/Last Update: 1900-01-01