[1]韦潋滟,徐冬娟.肠道微生物与缺血性脑卒中的相关性研究[J].医学信息,2021,34(11):40-42,46.[doi:10.3969/j.issn.1006-1959.2021.11.012]
 WEI Lian-yan,XU Dong-juan.Study on the Correlation Between Intestinal Microbes and Ischemic Stroke[J].Medical Information,2021,34(11):40-42,46.[doi:10.3969/j.issn.1006-1959.2021.11.012]
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肠道微生物与缺血性脑卒中的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年11期
页码:
40-42,46
栏目:
综述
出版日期:
2021-06-01

文章信息/Info

Title:
Study on the Correlation Between Intestinal Microbes and Ischemic Stroke
文章编号:
1006-1959(2021)11-0040-04
作者:
韦潋滟徐冬娟
(温州医科大学附属东阳医院神经内科,浙江 东阳 322100)
Author(s):
WEI Lian-yanXU Dong-juan
(Department of Neurology,Dongyang Hospital Affiliated to Wenzhou Medical University,Dongyang 322100,Zhejiang,China)
关键词:
肠道菌群缺血性脑卒中动脉粥样硬化
Keywords:
Intestinal floraIschemic strokeAtherosclerosis
分类号:
R743.1
DOI:
10.3969/j.issn.1006-1959.2021.11.012
文献标志码:
A
摘要:
肠道微生物对人体健康有着重要影响,其参与人体的新陈代谢、免疫炎症反应和维持肠道屏障结构等复杂的生理过程,肠道微生物的失调与人类所患的许多常见疾病相关。缺血性脑卒中的病因学基础主要是动脉粥样硬化,而肠道微生物与机体的免疫调节及炎症反应密切相关,通过识别受体Toll样受体、CD14分子,参与胆固醇、胆汁酸和脂肪代谢,而代谢产物氧化三甲胺(TMAO)促进动脉粥样硬化斑块形成,进而导致缺血性脑卒中的发生。本文就肠道微生物及动脉粥样硬化概述、肠道微生物与动脉粥样硬化的关系、肠道微生物-缺血性脑卒中预防的潜在靶点作一综述,以期为临床治疗提供参考。
Abstract:
Intestinal microbes have an important impact on human health,it participates in the body’s metabolism, immune inflammatory response and maintenance of the intestinal barrier structure and other complex physiological processes. The imbalance of intestinal microbes is related to many common diseases that humans suffer from.The etiological basis of ischemic stroke is mainly atherosclerosis, and intestinal microbes are closely related to the body’s immune regulation and inflammatory response.By recognizing receptors Toll-like receptors and CD14 molecules, it participates in cholesterol, bile acid and fat metabolism, and the metabolite trimethylamine oxide (TMAO) promotes the formation of atherosclerotic plaques, which in turn leads to the occurrence of ischemic stroke.This article summarizes the intestinal microbes and atherosclerosis, the relationship between intestinal microbes and atherosclerosis, and the potential targets of intestinal microbes-the prevention of ischemic stroke, in order to provide reference for clinical treatment.

参考文献/References:

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更新日期/Last Update: 1900-01-01