[1]张 杨,蒋 森,刘 娜,等.早期帕金森病步态障碍的临床特点及研究进展[J].医学信息,2022,35(06):34-36,40.[doi:10.3969/j.issn.1006-1959.2022.06.008]
　ZHANG Yang,JIANG Sen,LIU Na,et al.Clinical Features and Research Progress of Gait Disorder in Early Parkinson’s Disease[J].Medical Information,2022,35(06):34-36,40.[doi:10.3969/j.issn.1006-1959.2022.06.008]
点击复制

早期帕金森病步态障碍的临床特点及研究进展()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年06期
页码:
34-36,40
栏目:
综述
出版日期:
2022-03-15

文章信息/Info

Title:
Clinical Features and Research Progress of Gait Disorder in Early Parkinson’s Disease
文章编号:
1006-1959（2022）06-0034-04
作者:
张 杨; 蒋 森; 刘 娜; 等
（新疆医科大学第二附属医院神经内科，新疆 乌鲁木齐 830054）
Author(s):
ZHANG Yang; JIANG Sen; LIU Na; et al.
(Department of Neurology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
关键词:
帕金森病; 步态障碍; 震颤麻痹; 神经系统退行性病变; 生活质量
Keywords:
Parkinson’s disease; Gait disorder; Paralysis agitans; Nervous system degenerative disease; Quality of life
分类号:
R742.5
DOI:
10.3969/j.issn.1006-1959.2022.06.008
文献标志码:
A
摘要:
帕金森病（PD）是一种神经退行性疾病，目前尚无可以治愈的手段，其临床表现中的步态障碍与帕金森病患者的生活质量密切相关，也可作为病情发展的监测指标之一。目前，临床中主要可以通过量表评估、仪器检测以及影像学相关检查手段对步态障碍的患者进行早期诊断。但现阶段帕金森病步态障碍的发生机制仍不明确，目前主流的研究方向主要集中在改善评价方法及提高有效治疗手段等方面。现就早期帕金森病患者步态障碍的研究治疗现状综述如下。
Abstract:
Parkinson’s disease (PD) is a neurodegenerative disease, and there is no cure method at present. The gait disorder in its clinical manifestations is closely related to the quality of life of patients with Parkinson’s disease, and can also be used as one of the monitoring indicators of disease development. At present, early diagnosis of patients with gait disorder can be carried out mainly through scale assessment, instrument detection and imaging related examination. However, the mechanism of gait disorder in Parkinson’s disease is still unclear. At present, the mainstream research direction mainly focuses on improving evaluation methods and improving effective treatment methods. Here is to make a review on the research and treatment of gait disorders in early Parkinson’s disease disease patients.

参考文献/References:

[1]中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍学组.中国帕金森病治疗指南(第四版)[J].中华神经科杂志,2020,53(12):973-986.[2]Musulin I.The Effects of Exercise on People with Parkinson’s Disease—Review[J].Advances in Parkinsons Disease,2017,6(1):24-28.[3]丁妹,朱雨婷,陆珍辉,等.影响帕金森病患者认知功能的独立危险因素分析[J].中国实用神经疾病杂志,2020,23(18):1590-1595.[4]Magrinelli F,Picelli A,Tocco P,et al.Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation[J].Parkinsons Dis,2016(2016):9832839.[5]Tysnes OB,Storstein A.Epidemiology of Parkinson’s disease[J].J Neural Transm,2017,124(8):901-905.[6]赵嘉豪,万赢,宋璐,等.早期帕金森病患者步态特征定量分析的初步探索[J].中华神经科杂志,2020,53(7):485-492.[7]Takakusaki K.Functional Neuroanatomy for Posture and Gait Control[J].J Mov Disord,2017,10(1):1-17.[8]Mirelman A,Shema S,Maidan I,et al.Gait[J].Handb Clin Neurol,2018(159):119-134.[9]房进平,刘永红,方伯言.帕金森病步态障碍分型及个体化康复策略[J].中华医学杂志,2020,100(43):3472-3474.[10]Spagnolo F,Rini AM,Guida P,et al.The Choice of Leg During Pull Test in Parkinson’s Disease: Not Mere Chance[J].Front Neurol,2020(11):302.[11]Rios Romenets S,Anang J,Fereshtehnejad SM,et al.Tango for treatment of motor and non-motor manifestations in Parkinson’s disease: a randomized control study[J].Complement Ther Med,2015,23(2):175-184.[12]Silva-Batista C,de Lima-Pardini AC,Nucci MP,et al.A Randomized, Controlled Trial of Exercise for Parkinsonian Individuals With Freezing of Gait[J].Mov Disord,2020,35(9):1607-1617.[13]Yoo JE,Jang W,Shin DW,et al.Timed Up and Go Test and the Risk of Parkinson’s Disease: A Nation-wide Retrospective Cohort Study[J].Mov Disord,2020,35(7):1263-1267.[14]Bloem BR,Marinus J,Almeida Q,et al.Movement Disorders Society Rating Scales Committee.Measurement instruments to assess posture, gait, and balance in Parkinson’s disease: Critique and recommendations[J].Mov Disord,2016,31(9):1342-1355.[15]Appeadu M,Bordoni B.Falls and Fall Prevention In The Elderly[EB/OL].https://www.ncbi.nlm.nih.gov/books/NBK5607 61/,2021-08-07/2021-10-10.[16]Walker Z,Gandolfo F,Orini S,et al.EANM-EAN Task Force for the recommendation of FDG PET for Dementing Neurodegenerative Disorders.Clinical utility of FDG PET in Parkinson’s disease and atypical parkinsonism associated with dementia[J].Eur J Nucl Med Mol Imaging,2018,45(9):1534-1545.[17]Filippi M,Elisabetta S,Piramide N,et al.Functional MRI in Idiopathic Parkinson’s Disease[J].Int Rev Neurobiol,2018(141):439-467.[18]Atkinson-Clement C,Pinto S,Eusebio A,et al.Diffusion tensor imaging in Parkinson’s disease: Review and meta-analysis[J].Neuroimage Clin,2017(16):98-110.[19]卢瑞瑞,李晓晖,陈文武,等.可穿戴设备在帕金森病冻结步态领域的临床应用[J].中华物理医学与康复杂志,2021,43(10):947-949.[20]Lamont RM,Daniel HL,Payne CL,et al.Accuracy of wearable physical activity trackers in people with Parkinson’s disease[J].Gait Posture,2018(63):104-108.[21]Lei C,Sunzi K,Dai F,et al.Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson’s disease: A systematic review[J].PLoS One,2019,14(11):e0224819.[22]Zhan A,Mohan S,Tarolli C,et al.Using Smartphones and Machine Learning to Quantify Parkinson Disease Severity: The Mobile Parkinson Disease Score[J].JAMA Neurol,2018,75(7):876-880.[23]Espay AJ,Bonato P,Nahab FB,et al.Movement Disorders Society Task Force on Technology. Technology in Parkinson’s disease: Challenges and opportunities[J].Mov Disord,2016,31(9):1272-1282.[24]Fox SH,Katzenschlager R,Lim SY,et al.Movement Disorder Society Evidence-Based Medicine Committee. International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson’s disease[J].Mov Disord,2018,33(8):1248-1266.[25]Mizuno Y,Shimoda S,Origasa H.Long-term treatment of Parkinson’s disease with levodopa and other adjunctive drugs[J].J Neural Transm (Vienna),2018,125(1):35-43.[26]Dinh P.A Transitional Probability Model for Parkinson’s Disease Motor States With Applications to Missing Data[J].Ther Innov Regul Sci,2019,53(4):420-425.[27]Modi NB,Mittur A,Rubens R,et al.Single-Dose Pharmacokinetics and Pharmacodynamics of IPX203 in Patients With Advanced Parkinson Disease: A Comparison With Immediate-Release Carbidopa-Levodopa and With Extended-Release Carbidopa-Levodopa Capsules[J].Clin Neuropharmacol,2019,42(1):4-8.[28]孟凡刚,陈玲,刘钰晔,等.中国帕金森病脑深部电刺激疗法专家共识(第二版)解读[J].中华神经外科杂志,2021,37(5):439-442.[29]Malek N.Deep Brain Stimulation in Parkinson’s Disease[J].Neurol India,2019,67(4):968-978.[30]Radder DLM,Sturkenboom IH,van Nimwegen M,et al.Physical therapy and occupational therapy in Parkinson’s disease[J].Int J Neurosci,2017,127(10):930-943.[31]Abbruzzese G,Marchese R,Avanzino L,et al.Rehabilitation for Parkinson’s disease: Current outlook and future challenges[J].Parkinsonism Relat Disord,2016,22(Suppl 1):S60-S64.

相似文献/References:

[1]王姝,莫英绪,王大成.帕金森病发病因素的研究现状[J].医学信息,2018,31(01):46.[doi:10.3969/j.issn.1006-1959.2018.01.017]
　WANG Shu,MO Ying-xu,WANG Da-cheng.Research Status of the Factors of Parkinson's Disease[J].Medical Information,2018,31(06):46.[doi:10.3969/j.issn.1006-1959.2018.01.017]
[2]刘 阳,王惠凌,安 迪,等.进行性核上性麻痹1例报告[J].医学信息,2018,31(05):192.[doi:10.3969/j.issn.1006-1959.2018.05.073]
[3]樊 毅.帕金森病嗅觉改变的相关性研究[J].医学信息,2018,31(17):95.[doi:10.3969/j.issn.1006-1959.2018.17.029]
　FAN Yi.Correlation Study of Olfactory Changes in Parkinson's Disease[J].Medical Information,2018,31(06):95.[doi:10.3969/j.issn.1006-1959.2018.17.029]
[4]侯晓丽,张亚慧,唐迎乐.人参皂苷Rg3对帕金森病模型大鼠多巴胺能神经元氧化应激的抑制作用[J].医学信息,2023,36(19):88.[doi:10.3969/j.issn.1006-1959.2023.19.018]
　HOU Xiao-li,ZHANG Ya-hui,TANG Ying-le.Inhibitory Effect of Ginsenoside Rg3 on Oxidative Stress in Dopaminergic Neurons of Parkinson’s Disease Model Rats[J].Medical Information,2023,36(06):88.[doi:10.3969/j.issn.1006-1959.2023.19.018]
[5]陈凤全.帕金森病的诊治现状及进展[J].医学信息,2020,33(12):43.[doi:10.3969/j.issn.1006-1959.2020.12.014]
　CHEN Feng-quan.Status and Progress of Diagnosis and Treatment of Parkinson’s Disease[J].Medical Information,2020,33(06):43.[doi:10.3969/j.issn.1006-1959.2020.12.014]
[6]张 磊,张巧俊,惠艳娉.经颅直流电刺激调控帕金森病抑郁相关的脑环路及机制[J].医学信息,2022,35(21):159.[doi:10.3969/j.issn.1006-1959.2022.21.043]
　ZHANG Lei,ZHANG Qiao-jun,HUI Yan-ping.Transcranial Direct Current Stimulation Regulates Depression-related Brain Circuits and Mechanism in Parkinson’s Disease[J].Medical Information,2022,35(06):159.[doi:10.3969/j.issn.1006-1959.2022.21.043]
[7]邓伟胜,楼云龙,苏中振.正电子发射断层扫描PET/CT在帕金森病患者早期诊断中的应用[J].医学信息,2020,33(18):170.[doi:10.3969/j.issn.1006-1959.2020.18.057]
　DENG Wei-sheng,LOU Yun-long,SU Zhong-zhen.Application of Positron Emission Tomography PET/CT in Early Diagnosis of Parkinson’s Disease[J].Medical Information,2020,33(06):170.[doi:10.3969/j.issn.1006-1959.2020.18.057]
[8]贺诗佳,孙 玲,张树山.脑内肾素-血管紧张素系统在帕金森病发病机制中的作用研究[J].医学信息,2021,34(03):34.[doi:10.3969/j.issn.1006-1959.2021.03.011]
　HE Shi-jia,SUN Ling,ZHANG Shu-shan.Study on the Role of Renin-angiotensin System in the Pathogenesis of Parkinson’s Disease[J].Medical Information,2021,34(06):34.[doi:10.3969/j.issn.1006-1959.2021.03.011]
[9]许红玉,梅育嘉,罗杰峰.神经节苷脂联合复方左旋多巴治疗帕金森病的效果[J].医学信息,2021,34(03):160.[doi:10.3969/j.issn.1006-1959.2021.03.045]
　XU Hong-yu,MEI Yu-jia,LUO Jie-feng.The Effect of Ganglioside Combined with Benserazide in the Treatment of Parkinson’s Disease[J].Medical Information,2021,34(06):160.[doi:10.3969/j.issn.1006-1959.2021.03.045]
[10]胡方婷,薛冬辉.运动-心理-睡眠护理干预对帕金森病患者负性情绪的影响[J].医学信息,2021,34(05):181.[doi:10.3969/j.issn.1006-1959.2021.05.053]
　HU Fang-ting,XUE Dong-hui.Effects of Exercise-psychological-sleep Nursing Intervention on Negative Emotions in Patients with Parkinson’s Disease[J].Medical Information,2021,34(06):181.[doi:10.3969/j.issn.1006-1959.2021.05.053]

更新日期/Last Update: 1900-01-01