[1]金力荣,杨麦青,徐洪波,等.TGF-β1、HIF-1α在输卵管妊娠中的表达和意义[J].医学信息,2022,35(08):85-88.[doi:10.3969/j.issn.1006-1959.2022.08.020]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.The Expression and Significance of TGF-β1, HIF-1α in Tubal Pregnancy[J].Medical Information,2022,35(08):85-88.[doi:10.3969/j.issn.1006-1959.2022.08.020]
点击复制

TGF-β1、HIF-1α在输卵管妊娠中的表达和意义()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年08期
页码:
85-88
栏目:
论著
出版日期:
2022-04-15

文章信息/Info

Title:
The Expression and Significance of TGF-β1, HIF-1α in Tubal Pregnancy
文章编号:
1006-1959（2022）08-0085-04
作者:
金力荣; 杨麦青; 徐洪波; 等
（1.昌邑市人民医院产科，山东 昌邑 261300；2.昌邑市人民医院病理科，山东 昌邑 261300；3.潍坊市人民医院病理科，山东 潍坊 261041；4.昌邑市人民医院输血科，山东 昌邑 261300；5.潍坊护理职业学院健康管理系，山东 潍坊 261041）
Author(s):
JIN Li-rong; YANG Mai-qing; XU Hong-bo; et al.
(1.Department of Obstetrics,Changyi People’s Hospital,Changyi 261300,Shandong,China;2.Department of Pathology,Changyi People’s Hospital,Changyi 261300,Shandong,China;3.Department of Pathology,Weifang People’s Hospital,Weifang 261041,Shandong,China;4.Department of Blood Transfusion,Changyi People’s Hospital,Changyi 261300,Shandong,China;5.Department of Health Management,Weifang Nursing Vocational College,Weifang 261041,Shandong,China)
关键词:
输卵管妊娠; TGF-β1; HIF-1α
Keywords:
Tubal pregnancy; TGF-β1; HIF-1α
分类号:
R714.22
DOI:
10.3969/j.issn.1006-1959.2022.08.020
文献标志码:
A
摘要:
目的 分析输卵管妊娠患者血清中TGF-β1和HIF-1α的表达水平及在输卵管妊娠诊断中的诊断价值。方法 选取2019年1月-2021年9月昌邑市人民医院诊断为输卵管妊娠的患者40例作为实验组，同时选取30名健康产妇作为对照组，比较两组TGF-β1、β-hCG、P、HIF-1α水平，并分析TGF-β1、HIF-1α低表达与临床病理参数的关系及TGF-β1与HIF-1α的相关性，另采用受试者操作特征（ROC）曲线评估TGF-β1、HIF-1α在输卵管妊娠中的诊断价值。结果 实验组血清TGF-β1、HIF-1α、β-hCG、P水平低于对照组，差异有统计学意义（P＜0.05）；TGF-β1、HIF-1α低表达与血清β-hCG、P的表达有关（P＜0.05），而与年龄、孕次、产次、收缩压、舒张压、体质指数无关（P＞0.05）；血清TGF-β1低表达与HIF-1α低表达呈正相关（r＝0.341，P＝0.016）；ROC曲线分析显示，血清TGF-β1低表达用于诊断输卵管妊娠的曲线下面积是0.721，血清HIF-1α低表达用于诊断输卵管妊娠的曲线下面积是0.692。结论 输卵管妊娠患者血清TGF-β1、HIF-1α的表达降低，TGF-β1、HIF-1α的低表达水平分别与β-hCG、P的表达有关，血清TGF-β1和HIF-1α低表达用于输卵管妊娠诊断的敏感性较高。
Abstract:
Objective To analyze the expression levels of TGF-β1 and HIF-1α in serum of patients with tubal pregnancy and its diagnostic value in the diagnosis of tubal pregnancy.Methods A total of 40 patients with tubal pregnancy diagnosed in Changyi People’s Hospital from January 2019 to September 2021 were selected as the experimental group, and 30 healthy pregnant women were selected as the control group. The levels of TGF-β1, β-hCG, P and HIF-1α in the two groups were compared, and the relationship between the low expression of TGF-β1 and HIF-1α and clinical pathological parameters and the correlation between TGF-β1 and HIF-1α were analyzed. In addition, the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of TGF-β1 and HIF-1α in tubal pregnancy.Results The serum levels of TGF-β1, HIF-1α, β-hCG and P in the experimental group were lower than those in the control group, and the difference was statistically significant (P<0.05). The low expression of TGF-β1 and HIF-1α was related to the expression of serum β-hCG and P (P<0.05), was not related to age, pregnancy, parity, systolic blood pressure, diastolic blood pressure and body mass index (P>0.05). The low expression of serum TGF-β1 was positively correlated with the low expression of HIF-1α (r=0.341,P=0.016). ROC curve analysis showed that the area under the curve of serum TGF-β1 low expression for diagnosis of tubal pregnancy was 0.721, and the area under the curve of serum HIF-1α low expression for diagnosis of tubal pregnancy was 0.692.Conclusion The expression of serum TGF-β1 and HIF-1α in patients with tubal pregnancy is decreased, and the low expression levels of TGF-β1 and HIF-1α are related to the expression of β-hCG and P, respectively. The low expression of serum TGF-β1 and HIF-1α is highly sensitive for the diagnosis of tubal pregnancy.

参考文献/References:

[1]Chouinard M,Mayrand MH,Ayoub A,et al.Ectopic pregnancy and outcomes of future intrauterine pregnancy[J].Fertil Steril,2019,112(1):112-119.[2]Dardalas I,Rigopoulos P,Pourzitaki C.Treatment of ectopic pregnancy with methotrexate[J].Arch Gynecol Obstet,2019,300(4):1093-1094.[3]Hawrylyshyn K,McLeod SL,Thomas J,et al.Ectopic pregnancy outcomes in patients discharged from the emergency department[J].CJEM,2019,21(1):71-74.[4]Liénart S,Merceron R,Vanderaa C,et al.Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells[J].Science,2018,362(6417):952-956.[5]叶淑芳,吴俊,雷文芬,等.MMP-9 TIMP-1及TGF-β对支气管哮喘患儿病情严重程度的评估价值[J].中国妇幼保健,2021,36(21):4973-4975.[6]廖宏伟,李学栋,康智,等.羟基磷灰石/转化生长因子-β1对急性肩袖损伤大鼠腱骨愈合的促进作用[J].中华实用诊断与治疗杂志,2021,35(11):1148-1152.[7]Liu J,Zhao B,Zhu H,Pan Q,et al.Wnt4 negatively regulates the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK[J].Cell Tissue Res,2020,379(3):537-548.[8]Schrumpf JA,Ninaber DK,van der Does AM,et al.TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms[J].J Innate Immun,2020,12(1):74-89.[9]Dai G,Sun B,Gong T,et al.Ginsenoside Rb2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by suppressing TGF-β/Smad signaling[J].Phytomedicine,2019(56):126-135.[10]Ding A,Bian YY,Zhang ZH.SP1/TGF?β1/SMAD2 pathway is involved in angiogenesis during osteogenesis[J].Mol Med Rep,2020,21(3):1581-1589.[11]Baddela VS,Sharma A,Michaelis M,et al.HIF1 driven transcriptional activity regulates steroidogenesis and proliferation of bovine granulosa cells[J].Sci Rep,2020,10(1):3906.[12]Sun J,Shen H,Shao L,et al.HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis[J].Stem Cell Res Ther,2020,11(1):373.[13]Li H,Jia Y,Wang Y.Targeting HIF-1α signaling pathway for gastric cancer treatment[J].Pharmazie,2019,74(1):3-7.[14]Xu WN,Zheng HL,Yang RZ,et al.HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway[J].Front Endocrinol (Lausanne),2020(10):922.[15]Li HS,Zhou YN,Li L,et al.HIF-1α protects against oxidative stress by directly targeting mitochondria[J].Redox Biol,2019(25):101109.[16]缪芳,郭叶青,姚穗.低氧诱导因子-1α/腺病毒E1B 19 kDa蛋白3在高龄孕妇流产中的作用机制[J].中国妇产科临床杂志,2021,22(6):649-651.[17]Wang X,Lee CL,Li RHW,et al.Alteration of the immune cell profiles in the pathophysiology of tubal ectopic pregnancy[J].Am J Reprod Immunol,2019,81(4):e13093.[18]Hawrylyshyn K,McLeod SL,Thomas J,et al.Methotrexate for the treatment of unruptured tubal ectopic pregnancy[J].CJEM,2019,21(3):391-394.[19]Qian W,Cai X,Qian Q,et al.Astragaloside IV modulates TGF-β1-dependent epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis[J].J Cell Mol Med,2018,22(9):4354-4365.[20]Xie J,Cao Y.Expression of TGF-β1 and miR-99a in serum of patients with early spontaneous abortion and correlation with hormone levels during pregnancy[J].Exp Ther Med,2019,17(6):4593-4597.

相似文献/References:

[1]胡晓华.单侧输卵管妊娠缝扎系膜血管止血保留输卵管自然受孕1例[J].医学信息,2018,31(04):190.[doi:10.3969/j.issn.1006-1959.2018.04.073]
[2]黄 花,徐冬冬,章丽霞.TGF-β1在宫颈癌中的研究进展[J].医学信息,2018,31(12):31.[doi:10.3969/j.issn.1006-1959.2018.12.011]
　HUANG Hua,XU Dong-dong,ZHANG Li-xia.Research Progress of TGF-β1 in Cervical Cancer[J].Medical Information,2018,31(08):31.[doi:10.3969/j.issn.1006-1959.2018.12.011]
[3]李 莹,杨 宇,王 迪,等.Ang-2对肝再生作用机制的研究进展[J].医学信息,2019,32(03):31.[doi:10.3969/j.issn.1006-1959.2019.03.011]
　LI Ying,YANG Yu,WANG Di,et al.Progress in Research on the Mechanism of Ang-2 on Liver Regeneration[J].Medical Information,2019,32(08):31.[doi:10.3969/j.issn.1006-1959.2019.03.011]
[4]韩玉丽,刘琪琪,李 真,等.增生性瘢痕分子信号通路研究[J].医学信息,2019,32(22):31.[doi:10.3969/j.issn.1006-1959.2019.22.011]
　HAN Yu-li,LIU Qi-qi,LI Zhen,et al.Study on Molecular Signaling Pathway of Hypertrophic Scar[J].Medical Information,2019,32(08):31.[doi:10.3969/j.issn.1006-1959.2019.22.011]
[5]金力荣,杨麦青,徐洪波,等.TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义[J].医学信息,2022,35(11):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest[J].Medical Information,2022,35(08):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
[6]齐宏峰,刘金香,庞大斌,等.TIPE2、TGF-β1在非小细胞肺癌中的表达和意义[J].医学信息,2023,36(20):109.[doi:10.3969/j.issn.1006-1959.2023.20.020]
　QI Hong-feng,LIU Jin-xiang,PANG Da-bin,et al.The Expression and Significance of TIPE2 and TGF-β1 in Non-small Cell Lung Cancer[J].Medical Information,2023,36(08):109.[doi:10.3969/j.issn.1006-1959.2023.20.020]
[7]李元庆,付亚宁,张丽娟,等.TGF-β1、IL-5、IL-10在过敏性鼻炎中的意义[J].医学信息,2023,36(22):128.[doi:10.3969/j.issn.1006-1959.2023.22.029]
　LI Yuan-qing,FU Ya-ning,ZHANG Li-juan,et al.Significance of TGF-β1, IL-5 and IL-10 in Allergic Rhinitis[J].Medical Information,2023,36(08):128.[doi:10.3969/j.issn.1006-1959.2023.22.029]
[8]李 璟,光晓燕,于 琳,等.二孩政策实施前后异位妊娠临床特征的变化分析[J].医学信息,2023,36(23):13.[doi:10.3969/j.issn.1006-1959.2023.23.004]
　LI Jing,GUANG Xiao-yan,YU Lin,et al.Changes of Clinical Characteristics of Ectopic Pregnancy Before and After the Implementation of the Two-child Policy[J].Medical Information,2023,36(08):13.[doi:10.3969/j.issn.1006-1959.2023.23.004]
[9]吴士爱.阴道超声检查指标联合人绒毛膜促性腺激素 判断输卵管妊娠保守治疗效果的价值[J].医学信息,2025,38(02):132.[doi:10.3969/j.issn.1006-1959.2025.02.025]
　WU Shiai.Value of Vaginal Ultrasonography Combined with Human Chorionic Gonadotropin in Judging the Effect of Conservative Treatment of Tubal Pregnancy[J].Medical Information,2025,38(08):132.[doi:10.3969/j.issn.1006-1959.2025.02.025]
[10]金力荣,杨麦青,徐洪波,等.TGF-β1、MMP-9、VEGF在输卵管妊娠中的表达和意义[J].医学信息,2022,35(12):122.[doi:10.3969/j.issn.1006-1959.2022.12.029]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.The Expression and Significance of TGF-β1, MMP-9, VEGF in Tubal Pregnancy[J].Medical Information,2022,35(08):122.[doi:10.3969/j.issn.1006-1959.2022.12.029]

更新日期/Last Update: 1900-01-01