[1]罗 嫄,胡泽锴.高效液相色谱法测定呋塞米片的含量及含量均匀度[J].医学信息,2022,35(09):19-21.[doi:10.3969/j.issn.1006-1959.2022.09.005]
　LUO Yuan,HU Ze-kai.HPLC Determination of Furosemide Tablets and its Content Uniformity[J].Medical Information,2022,35(09):19-21.[doi:10.3969/j.issn.1006-1959.2022.09.005]
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高效液相色谱法测定呋塞米片的含量及含量均匀度()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年09期
页码:
19-21
栏目:
药学信息学
出版日期:
2022-05-01

文章信息/Info

Title:
HPLC Determination of Furosemide Tablets and its Content Uniformity
文章编号:
1006-1959（2022）09-0019-03
作者:
罗 嫄; 胡泽锴
（成都市药品检验研究院化学室，四川 成都 610045）
Author(s):
LUO Yuan; HU Ze-kai
(Chemical Department,Chengdu Institute for Drug Control,Chengdu 610045,Sichuan,China）
关键词:
呋塞米片; 含量测定; 含量均匀度; 高效液相色谱法
Keywords:
Furosemide tablets; Content determination; Content uniformity; High performance liquid chromatography
分类号:
R927.2
DOI:
10.3969/j.issn.1006-1959.2022.09.005
文献标志码:
A
摘要:
目的 建立HPLC法测定呋塞米片的含量及含量均匀度。方法 采用十八烷基硅烷键合硅胶为填充剂，柱温30 ℃，流速1.0 ml/min，以水-四氢呋喃-冰醋酸（70∶30∶1）为流动相，检测波长为272 nm。结果 呋塞米的线性范围为0.056~0.168 mg/ml（R2=0.9999）；平均回收率为100.1%（RSD为1.2%，n=9）；15批次样品呋塞米含量在97.4%~105.2%，含量均匀度值（A+2.2S）在3.1~12.1。结论 经方法学验证，该方法准确、专属性强、重现性好，可作为呋塞米片的含量及含量均匀度检测方法。
Abstract:
Objective To establishan HPLC method for the determination of furosemide tablets and its content uniformity.Methods The octadecylsilane bonded silica gel was used as the filler, the column temperature was 30 ℃, the flow rate was 1.0 ml/min, the mobile phase was water-tetrahydrofuran-glacial acetic acid (70∶30∶1), and the detection wavelength was 272 nm.Results The linear range of furosemide was 0.056–0.168 mg/ml (R2=0.9999); the average recovery was 100.1% (RSD=1.2%, n=9); the content of furosemide in 15 batches of sam ples ranged from 97.4% to 105.2%, and the content uniformity (A+2.2S) ranged from 3.1 to 12.1.Conclusion The method is accurate, specific and reproducible, which can be used for the determination of content and content uniformity of furosemide tablets.

参考文献/References:

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更新日期/Last Update: 1900-01-01