[1]王 伟,宫秀群,余 亮.阿替普酶治疗急性脑梗死患者临床转归的影响因素[J].医学信息,2022,35(11):84-88.[doi:10.3969/j.issn.1006-1959.2022.11.022]
　WANG Wei,GONG Xiu-qun,YU Liang.The Influencing Factors of Clinical Outcome in Patients with Acute Cerebral Infarction Treated with Alteplase[J].Medical Information,2022,35(11):84-88.[doi:10.3969/j.issn.1006-1959.2022.11.022]
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阿替普酶治疗急性脑梗死患者临床转归的影响因素()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
84-88
栏目:
论著
出版日期:
2022-06-01

文章信息/Info

Title:
The Influencing Factors of Clinical Outcome in Patients with Acute Cerebral Infarction Treated with Alteplase
文章编号:
1006-1959（2022）11-0084-05
作者:
王 伟; 宫秀群; 余 亮
（1.南京大学医学院附属盐城第一医院/盐城市第一人民医院神经内科，江苏 盐城 224001；2.淮南市第一人民医院神经内科，安徽 淮南 232001）
Author(s):
WANG Wei; GONG Xiu-qun; YU Liang
(1.Department of Internal Neurology,Yancheng First Hospital,Affiliated Hospital of Nanjing University Medical School/the First People’s Hospital of Yancheng,Yancheng 224001,Jiangsu,China;2.Department of Internal Neurology,the First People’s Hospital of
关键词:
急性脑梗死; 阿替普酶; 静脉溶栓; 溶栓时间窗
Keywords:
Acute cerebral infarction; Alteplase; Intravenous thrombolysis; Thrombolytic time window
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.11.022
文献标志码:
A
摘要:
目的 探讨急性脑梗死患者阿替普酶静脉溶栓治疗后转归的影响因素。方法 选取2018年10月-2019年9月淮南市第一人民医院神经内科收治的急性脑梗死患者139例作为研究对象，均于发病4.5 h内接受阿替普酶溶栓，根据发病3个月后临床转归情况分为转归良好组和转归不良组。采用单因素及多因素Logistic回归分析影响影响阿替普酶溶栓临床转归的独立危险因素。结果 有71例患者转归良好，68例转归不良。两组年龄、收缩压、随机血糖、空腹血糖、中性粒细胞计数、基线NIHSS评分、溶栓时间窗比较，差异有统计学意义（P＜0.05）；多变量Logistic回归分析显示，基线NIHSS评分（OR：1.495，95%CI：1.303~1.715，P=0.000）、空腹血糖（OR：1.369，95%CI：1.052~1.775，P=0.018）、中性粒细胞计数（OR：1.264，95%CI：1.016~1.573，P=0.035）是影响阿替普酶溶栓临床转归的独立危险因素。结论 基线NIHSS评分、空腹血糖、中性粒细胞计数与急性脑梗死阿替普酶溶栓治疗的临床转归密切相关。
Abstract:
Objective To investigate the influencing factors of outcome after intravenous thrombolysis with alteplase in patients with acute cerebral infarction.Methods A total of 139 patients with acute cerebral infarction admitted to the Department of Neurology, the First People’ s Hospital of Huainan from October 2018 to September 2019 were selected as the research objects. All patients received alteplase thrombolysis within 4.5 h of onset. According to the clinical outcome after 3 months of onset, they were divided into good outcome group and poor outcome group. Single factor and multiple factor logistic regression analysis were used to analyze the independent risk factors affecting the clinical outcome of alteplase thrombolysis.Results There were 71 patients with good outcome and 68 patients with poor outcome. There were statistically significant differences in age, systolic blood pressure, random blood glucose, fasting blood glucose, neutrophil count, baseline NIHSS score thrombolytic time window between the two groups (P<0.05). Multivariate logistic regression analysis showed that baseline NIHSS score (OR:1.495, 95%CI:1.303-1.715, P=0.000 ), fasting blood glucose (OR:1.369, 95%CI:1.052-1.775, P=0.018), neutrophil count (OR:1.264, 95%CI:1.016-1.573, P=0.035) were independent risk factors affecting the clinical outcome of alteplase thrombolysis.Conclusion The baseline NIHSS score, fasting blood glucose and neutrophil count are closely related to the outcome of thrombolytic therapy with alteplase for acute cerebral infarction.

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更新日期/Last Update: 1900-01-01