[1]陈 雨,卢业才.HMMR基因在结肠癌中的表达及其对患者预后的影响[J].医学信息,2023,36(12):8-12.[doi:10.3969/j.issn.1006-1959.2023.12.002]
　CHEN Yu,LU Ye-cai.Expression of HMMR Gene in Colon Cancer and its Effect on the Prognosis[J].Journal of Medical Information,2023,36(12):8-12.[doi:10.3969/j.issn.1006-1959.2023.12.002]
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HMMR基因在结肠癌中的表达及其对患者预后的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年12期
页码:
8-12
栏目:
生物信息学
出版日期:
2023-06-15

文章信息/Info

Title:
Expression of HMMR Gene in Colon Cancer and its Effect on the Prognosis
文章编号:
1006-1959（2023）12-0008-05
作者:
陈 雨; 卢业才
（安徽医科大学附属巢湖医院胃肠外科，安徽 巢湖 238000）
Author(s):
CHEN Yu; LU Ye-cai
(Department of Gastrointestinal Surgery,Chaohu Hospital of Anhui Medical University,Chaohu 238000,Anhui,China)
关键词:
结肠癌; HMMR; 信号通路; PI3K-AKT-mTOR
Keywords:
Colon cancer; HMMR; Signaling pathways; PI3K-AKT-mTOR
分类号:
R735.3+5
DOI:
10.3969/j.issn.1006-1959.2023.12.002
文献标志码:
A
摘要:
目的 采用生物学方法探究HMMR基因在结肠癌中的表达，分析其与结肠癌患者预后的关系。方法 利用R语言相关软件包对NCBI数据库中GSE140973样本进行筛选和分析获取差异表达基因，通过GO分析和KEGG分析进行功能和途径富集分析、并对其进行PPI网络构建，通过Cytoscape软件对PPI网络进行可视化以及获取Hub基因，通过GEPIA平台进行差异表达分析和生存分析，最终筛选出目标基因。结果 在GSE140973中共发现807个DEGs；GO分析和KEGG分析显示，DEGs主要富集在有丝分裂细胞周期、染色体分离、糖酵解/糖异生、细胞周期等过程中，进一步分析获得HMMR、SHCBP1、ERCC6L、ZWINT、FAM83D、CDCA2、SPC25、SKA1、KIAA0101、MND1共10个Hub基因；生存分析和差异表达分析显示，HMMR基因在结肠癌组织和正常组织中的表达不同，其表达与患者预后有关。结论 在结直肠癌组织中HMMR基因呈高表达，且HMMR基因高表达与结肠癌患者预后相关。
Abstract:
Objective To explore the expression of HMMR gene in colon cancer by biological method and analyze its relationship with the prognosis of colon cancer patients.Methods The R language related software package was used to screen and analyze the GSE140973 samples in the NCBI database to obtain differentially expressed genes. GO analysis and KEGG analysis were used to perform functional and pathway enrichment analysis, and PPI network construction was performed. The PPI network was visualized by Cytoscape software and Hub genes were obtained. Differential expression analysis and survival analysis were performed through the GEPIA platform, and the target genes were finally screened.Results A total of 807 DEGs were found in GSE140973. GO analysis and KEGG analysis showed that DEGs were mainly enriched in mitotic cell cycle, chromosome separation, glycolysis/gluconeogenesis, cell cycle and other processes. Further analysis obtained 10 Hub genes including HMMR, SHCBP1, ERCC6 L, ZWINT, FAM83 D, CDCA2, SPC25, SKA1, KIAA0101 and MND1. Survival analysis and differential expression analysis showed that the expression of HMMR gene was different in colon cancer tissues and normal tissues, and its expression was related to the prognosis of patients.Conclusion HMMR gene is highly expressed in colon cancer, and the high expression of HMMR gene is related to the prognosis of colon cancer patients.

参考文献/References:

[1]Mody K,Bekaii-Saab T.Clinical Trials and Progress in Metastatic Colon Cancer[J].Surgical Oncology Clinics of North America,2018,27(2):349-365.[2]Lee JJ,Chu E.An update on treatment advances for the first-line therapy of metastatic colorectal cancer[J].Cancer Journal,2007,13(5):276-281.[3]Dennis G,Sherman B,Da H,et al.DAVID: Database for Annotation, Visualization, and Integrated Discovery[J].Genome Biology,2003,4(5):P3.[4]Shannon P.Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks[J].Genome Research,2003,13(11):2498-2504.[5]Bader GD,Hogue CWV.An Automated Method for Finding Molecular Complexes in Large Protein Interaction Networks[J].BMC Bioinformatics,2003,4(1,article 2):2.[6]Schulc K,Nagy ZT,Kamp S,et al.Modular Reorganization of Signaling Networks during the Development of Colon Adenoma and Carcinoma[J].The Journal of Physical Chemistry B,2021,125(7):1716-1726.[7]Cai Y,Sheng Z,Chen Y,et al.LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis[J].Aging,2019,11(10):3041-3054.[8]Li X,Zuo H,Zhang L,et al.Validating HMMR Expression and Its Prognostic Significance in Lung Adenocarcinoma Based on Data Mining and Bioinformatics Methods[J].Frontiers in Oncology,2021,11:3379.[9]吴良银,李文丽,刘俊.HMMR预测肝细胞癌预后的生物信息学分析[J].国际检验医学杂志,2022,43(12):1454-1457.[10]Xu F,Guan Y,Xue L,et al.The effect of a novel glycolysis-related gene signature on progression, prognosis and immune microenvironment of renal cell carcinoma[J].BMC Cancer,2020,20(1):1207.[11]He Z,Mei L,Connell M,et al.Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor[J].Cells,2020,9(4):819.[12]Chen H,Connell M,Mei L,et al.The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation[J].Molecular Biology of the Cell,2018,29(7):786-796.[13]Rui Z,Roostalu J,Surrey T,et al.Structural insight into TPX2-stimulated microtubule assembly[J].Elife,2017,6:e30959.[14]He Z,Mei L,Connell M,et al.Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor[J].Cells,2020,9(4):819.[15]熊超.结肠癌组织中RNF181、TPX2的表达量及其与癌细胞活力、血管新生的相关性分析[J].海南医学院学报,2017,23(14):1969-1971,1975.[16]Wei P,Zhang N,Xu Y,et al.TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer[J].Journal of Translational Medicine,2013,1(1):313.[17]Janku F,Yap TA,Meric-Bernstam F.Targeting the PI3K pathway in cancer: are we making headway?[J].Nat Rev Clin Oncol,2018,15(5):273-291.[18]胡晓青,于慧美,沈璐妍,等.PI3K/AKT/mTOR信号通路与线粒体稳态在疾病治疗中的作用[J].中国病理生理杂志,2021,37(11):2072-2076.[19]Liu M,Ran J,Zhou J.Non-canonical functions of the mitotic kinesin Eg5[J].Thoracic Cancer,2018,9(8):904-910.[20]Chu TLH,Connell M,Zhou L,et al.Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A[J].Molecular Cancer Research,2018,16(1):16-31.[21]Taherdangkoo K,Kazemi Nezhad SR,Hajjari MR,et al.miR-485-3p suppresses colorectal cancer via targeting TPX2[J].Bratisl Lek Listy,2020,121(4):302-307.[22]熊超.结肠癌组织中RNF181、TPX2的表达量及其与癌细胞活力、血管新生的相关性分析[J].海南医学院学报,2017,23(14):1969-1971,1975.

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更新日期/Last Update: 1900-01-01