[1]魏亚萍,王 晶.术前白蛋白与球蛋白比值在膀胱癌中的预后价值分析[J].医学信息,2023,36(20):63-68.[doi:10.3969/j.issn.1006-1959.2023.20.012]
 WEI Ya-ping,WANG Jing.Prognostic Value of Preoperative Albumin to Globulin Ratio in Bladder Cancer[J].Journal of Medical Information,2023,36(20):63-68.[doi:10.3969/j.issn.1006-1959.2023.20.012]
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术前白蛋白与球蛋白比值在膀胱癌中的预后价值分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年20期
页码:
63-68
栏目:
医学数据科学
出版日期:
2023-10-15

文章信息/Info

Title:
Prognostic Value of Preoperative Albumin to Globulin Ratio in Bladder Cancer
文章编号:
1006-1959(2023)20-0063-06
作者:
魏亚萍王 晶
(电子科技大学医学院附属绵阳市中心医院医学检验科,四川 绵阳 621000)
Author(s):
WEI Ya-pingWANG Jing
(Departmant of Clinical Laboratory,Mianyang Central Hospital,School of Medicine,University of Electronic Scienceand Technology of China,Mianyang 621000,Sichuan,China)
关键词:
白蛋白与球蛋白比值膀胱癌预后
Keywords:
Albumin to globulin ratioBladder cancerPrognosis
分类号:
R737.14
DOI:
10.3969/j.issn.1006-1959.2023.20.012
文献标志码:
A
摘要:
目的 探讨术前白蛋白-球蛋白比值(AGR)是否可作为预测膀胱癌患者预后的生物标志物。方法 系统检索PubMed、Web of Science、EMbase、中国知网和万方数据库中关于评估AGR与膀胱癌患者预后相关性的文章,检索时间为建库至2022年9月,采用Stata 14软件进行数据处理和统计分析。结果 共纳入9项研究,包含7034例膀胱癌患者。结果显示术前较低的AGR与患者较差的总生存期(HR=2.31,95%CI:1.16~4.59,P=0.000)、无复发生存期(HR=2.10,95%CI:1.23~3.58,P=0.134)、无进展生存期(HR=2.99,95%CI:1.97~4.55,P=0.000)以及肿瘤特异性生存期(HR=2.24,95%CI:1.18~4.25,P=0.002)相关。结论 术前AGR较低的患者生存期较差,AGR可作为临床实践中接受手术治疗的膀胱癌患者预后的有效标志物。
Abstract:
Objective To explore whether preoperative albumin to globulin ratio (AGR) can be used as a biomarker for predicting the prognosis of patients with bladder cancer.Methods PubMed, Web of Science, Embase, CNKI, and Wanfang databases were searched to screen articles on the correlation between AGR and prognosis of bladder cancer patients. The retrieval time was from the establishment of the database to September 2022. Stata 14 was used for data processing and statistical analysis.Results A total of nine studies involving 7034 patients with bladder cancer were included. The results showed that lower preoperative AGR was associated with poorer overall survival (HR=2.31,95CI:1.16-4.59,P=0.000), recurrence-free survival(HR=2.10,95%CI:1.23-3.58,P=0.134), progression-free survival(HR=2.99,95%CI:1.97-4.55,P=0.000), and cancer-specific survival (HR=2.24,95%CI:1.18-4.25,P=0.002).Conclusion Patients with lower preoperative AGR have poorer survival. AGR can be used as an effective prognostic marker for bladder cancer patients undergoing surgical treatment in clinical practice.

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更新日期/Last Update: 1900-01-01