[1]何佳纹.美托洛尔缓释片联合冠心苏合胶囊治疗冠心病不稳定型心绞痛的效果[J].医学信息,2025,38(02):120-123.[doi:10.3969/j.issn.1006-1959.2025.02.022]
　HE Jiawen.Effect of Metoprolol Sustained-release Tablets Combined with Guanxin Suhe Capsules in the Treatment of Unstable Angina Pectoris of Coronary Heart Disease[J].Journal of Medical Information,2025,38(02):120-123.[doi:10.3969/j.issn.1006-1959.2025.02.022]
点击复制

美托洛尔缓释片联合冠心苏合胶囊治疗冠心病不稳定型心绞痛的效果()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年02期
页码:
120-123
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Effect of Metoprolol Sustained-release Tablets Combined with Guanxin Suhe Capsules in the Treatment of Unstable Angina Pectoris of Coronary Heart Disease
文章编号:
1006-1959（2025）02-0120-04
作者:
何佳纹
呼伦贝尔市中蒙医院心血管病科，内蒙古 呼伦贝尔 021000
Author(s):
HE Jiawen
Department of Cardiovascular Diseases, Hulun Buir Zhongmeng Hospital, Hulun Buir 021000, Inner Mongolia, China
关键词:
冠心病; 不稳定型心绞痛; 美托洛尔缓释片; 冠心苏合胶囊; 中医症状
Keywords:
Coronary heart disease;  Unstable angina pectoris;  Metoprolol sustained-release tablets;  Guanxin Suhe capsules;  TCM symptom
分类号:
R541
DOI:
10.3969/j.issn.1006-1959.2025.02.022
文献标志码:
A
摘要:
目的 研究美托洛尔缓释片联合冠心苏合胶囊治疗冠心病不稳定型心绞痛（UAP）的临床效果。方法 选取2021年9月-2023年9月呼伦贝尔市中蒙医院收治的60例冠心病UAP患者，经随机数字表法分为对照组（30例）与观察组（30例）。对照组给予美托洛尔缓释片治疗，观察组在其基础上联合冠心苏合胶囊治疗，比较两组心绞痛发作情况（发作频率、发作持续时间）、中医症状积分、西雅图心绞痛量表（SAQ）、全球急性冠脉事件注册危险（GRACE）评分、药物不良反应。结果 观察组治疗后发作频率低于对照组、发作持续时间短于对照组（P＜0.05）；观察组治疗后中医症状积分（胸闷胀痛、心悸气短、头晕乏力）低于对照组（P＜0.05）；观察组治疗后SAQ评分高于对照组，GRACE评分低于对照组（P＜0.05）；两组药物不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 美托洛尔缓释片联合冠心苏合胶囊在冠心病UAP治疗中具有确切作用，可减少患者的心绞痛发生频率，缩短发作持续时间，改善其中医症状，缓解心绞痛病情，降低冠脉缺血危险等级，且用药安全性较高。
Abstract:
Objective To study the clinical effect of metoprolol sustained-release tablets combined with Guanxin Suhe capsules in the treatment of unstable angina pectoris (UAP) of coronary heart disease. Methods From September 2021 to September 2023, 60 patients with UAP of coronary heart disease admitted to Hulunbeier Zhongmeng Hospital were selected and divided into control group (30 patients) and observation group (30 patients) by random number table method. The control group was treated with metoprolol sustained-release tablets, and the observation group was treated with Guanxin Suhe capsules on the basis of the control group. The incidence of angina pectoris (frequency of attack, duration of attack), TCM symptom score, Seattle Angina Questionnaire (SAQ), Global Registry of Acute Coronary Events Risk (GRACE) score, adverse drug reactions were compared between the two groups. Results After treatment, the frequency of attack in the observation group was lower than that in the control group, and the duration of attack was shorter than that in the control group (P<0.05). After treatment, the scores of TCM symptoms (chest tightness and pain, palpitations and shortness of breath, dizziness and fatigue) in the observation group were lower than those in the control group (P<0.05). After treatment, the SAQ score of the observation group was higher than that of the control group, and the GRACE score was lower than that of the control group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). Conclusion Metoprolol sustained-release tablets combined with Guanxin Suhe capsules have a definite effect in the treatment of UAP in coronary heart disease, which can reduce the frequency of angina pectoris, shorten the duration of attack, improve the symptoms of traditional Chinese medicine, relieve the condition of angina pectoris, reduce the risk level of coronary ischemia, and the safety of medication is high.

参考文献/References:

[1]Wang G,Li F,Hou X.Complementary and alternative therapies for stable angina pectoris of coronary heart disease: A protocol for systematic review and network meta-analysis[J].Medicine,2022,101(7):e28850.[2]王晟,江文胜,王士芳,等.益心康泰胶囊联合美托洛尔治疗冠心病心绞痛的临床疗效观察[J].世界中医药,2022,17(18):2628-2631.[3]刘剑锋,况春燕,郭慧.基于网络药理学方法和分子对接技术探讨冠心苏合胶囊治疗冠心病的有效成分及作用机制[J].山西中医药大学学报,2023,24(5):547-554. [4]童杏,姜峰,沈俐,等.心通口服液联合美托洛尔对冠心病心绞痛患者血管内皮功能、心肌损伤指标和血清MMP-2、MMP-7、MMP-8、MMP-9的影响[J].现代生物医学进展,2023,23(9):1776-1780.[5]盛艳华,代永斌,唐碧,等.银杏酮酯滴丸联合美托洛尔对冠心病不稳定型心绞痛患者心肌酶指标、氧化应激和外周血IL-33/ST2信号通路的影响[J].现代生物医学进展,2022,22(23):4465-4469,4429.[6]邹燕,李理,邹亚芳.冠心苏合胶囊配合PCI治疗急性心肌梗死的疗效观察及对心功能、氧化应激指标水平的影响[J].中西医结合心脑血管病杂志,2020,18(7):1106-1109.[7]于长生,宫丽鸿.冠心病不稳定型心绞痛中西医结合康复治疗临床观察[J].辽宁中医药大学学报,2022,24(12):167-170.[8]《冠状动脉微血管病中西医结合诊疗指南》项目组.冠状动脉微血管病中西医结合诊疗指南[J].中国中西医结合杂志,2023,43(9):1029-1039.[9]史航.冠心舒通胶囊联合美托洛尔治疗冠心病稳定型心绞痛的疗效及对血脂、hs-CRP的影响[J].辽宁中医杂志,2022,49(9):137-140.[10]王海侠.美托洛尔联合阿司匹林对冠心病心绞痛患者疗效及对患者血清hs-CRP、sCD40L、IL-6水平的影响[J].河北医药,2022,44(7):1063-1066.[11]陈媛,林尤斌,吴清柳,等.冠心丹参滴丸对老年冠状动脉粥样硬化性心脏病不稳定型心绞痛患者血小板活化功能及血清MMP-9、sICAM-1及tPAI-1水平的影响[J].世界临床药物,2020,41(2):111-117.[12]叶剑.血府逐瘀汤联合美托洛尔治疗老年人冠心病心绞痛及对Hcy水平的影响[J].贵州医药,2021,45(9):1436-1437.[13]杨晓瑜,谈理,陈伟,等.地尔硫卓联合美托洛尔治疗冠心病不稳定型心绞痛的效果以及对血脂和运动耐力的影响[J].解放军医药杂志,2020,32(4):43-47.[14]孙慧,花继平.美托洛尔联合心脉通胶囊对老年冠心病患者血脂、心功能及血液流变学的影响分析[J].中南医学科学杂志,2020,48(1):18-21.[15]尹桂红,符会妮,彭晓燕.冠心苏合胶囊联合替格瑞洛治疗冠心病心绞痛的临床研究[J].现代药物与临床,2021,36(6):1149-1153.[16]赵小瑞.PCI联合冠心苏合胶囊对急性心肌梗死病人心功能及氧化应激水平的影响[J].中西医结合心脑血管病杂志,2018,16(21):3152-3154.[17]罗娜,齐贵彬.冠心苏合软胶囊联合美托洛尔治疗冠心病心绞痛的临床研究[J].现代药物与临床,2021,36(7):1475-1479.[18]勾韦华,张丹.冠心舒通胶囊联合美托洛尔治疗不稳定型心绞痛的疗效及对血液流变学、炎症因子的影响[J].中国医院用药评价与分析,2020,20(9):1075-1077,1082.[19]陶愈婷,黄积存,苏会钦.双参通络方治疗痰瘀互结型冠状动脉粥样硬化性心脏病心绞痛患者60例[J].环球中医药,2020,13(9):1534-1536.[20]刘文武,薛宪骏,罗显元,等.冠心丹参滴丸对老年冠心病不稳定型心绞痛气虚血瘀证患者血小板活化的影响——双盲安慰剂对照试验[J].中医杂志,2020,61(15):1339-1343.[21]刘健,加拉力丁·买买提,董新玲,等.益气活血方治疗冠心病不稳定型心绞痛临床研究[J].陕西中医,2021,42(8):1037-1040.[22]马艳梅,李琳.益气通脉方联合美托洛尔治疗冠心病心绞痛临床疗效观察[J].中华中医药学刊,2021,39(9):173-176.

相似文献/References:

[1]袁 帅,邢晓博,李 晓,等.MTHFR基因多态性与中年男性冠状动脉病变程度的相关研究[J].医学信息,2018,31(03):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
　YUAN Shuai,XING Xiao-bo,LI Xiao,et al.Association of MTHFR Gene Polymorphism with Coronary Artery Lesions in Middle-aged Men[J].Journal of Medical Information,2018,31(02):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
[2]张挺挺.经股和桡动脉介入治疗冠心病的临床疗效对比[J].医学信息,2018,31(03):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
　ZHANG Ting-ting.Comparison of Clinical Effects of Interventional Treatment of Coronary Heart Disease by Femoral and Radial Artery[J].Journal of Medical Information,2018,31(02):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
[3]迮艳华.稳心颗粒联合美托洛尔治疗冠心病心律失常的疗效分析[J].医学信息,2018,31(03):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
　ZE Yan-hua.Therapeutic Effect of Wenxin Granule Combined with Metoprolol on Arrhythmia of Coronary Heart Disease[J].Journal of Medical Information,2018,31(02):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
[4]张 旭.冠心病心绞痛患者进行护理干预的临床效果及 对护理质量影响研究[J].医学信息,2018,31(05):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
　ZHANG Xu.Clinical Effect of Nursing Intervention in Patients with Angina Pectoris of Coronary Heart Disease and its Influence on Nursing Quality[J].Journal of Medical Information,2018,31(02):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
[5]向明明,赵晓辉.黑龙江省东部地区汉族人群冠心病的危险因素研究[J].医学信息,2018,31(07):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
　XIANG Ming-ming,ZHAO Xiao-hui.Study on Risk Factors of Coronary Heart Disease in Han Nationality Population in Eastern Heilongjiang Province[J].Journal of Medical Information,2018,31(02):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
[6]王 坤,张永春.血清胆红素水平、单核细胞数、红细胞分布宽度与 冠状动脉病变程度的关系[J].医学信息,2018,31(08):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
　WANG Kun,ZHANG Yong-chun.Relationship between Serum Bilirubin Level,Monocyte Count,Red Blood Cell Distribution Width and Severity of Coronary Artery Disease[J].Journal of Medical Information,2018,31(02):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
[7]毛红岩.冠状动脉介入治疗冠心病的疗效及 对患者血清炎症因子的影响[J].医学信息,2018,31(10):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
　MAO Hong-yan.Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors[J].Journal of Medical Information,2018,31(02):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
[8]杨锦龙,刘 欢,吕秋菊,等.非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究[J].医学信息,2018,31(10):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
　YANG Jin-long,LIU Huan,LV Qiu-ju,et al.Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients[J].Journal of Medical Information,2018,31(02):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
[9]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,31(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
　LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Journal of Medical Information,2018,31(02):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[10]宫丽萍.血府逐瘀汤加减治疗气滞血瘀型冠心病心绞痛的疗效研究[J].医学信息,2018,31(12):145.[doi:10.3969/j.issn.1006-1959.2018.12.046]
　GONG Li-ping.Therapeutic Effect of Xuefu Zhuyu Decoction on Angina Pectoris with Qi Stagnation and Blood Stasis[J].Journal of Medical Information,2018,31(02):145.[doi:10.3969/j.issn.1006-1959.2018.12.046]
[11]周忠梅.前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响[J].医学信息,2019,32(20):147.[doi:10.3969/j.issn.1006-1959.2019.20.046]
　ZHOU Zhong-mei.Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients[J].Journal of Medical Information,2019,32(02):147.[doi:10.3969/j.issn.1006-1959.2019.20.046]
[12]李 泉,曾丽红,曾艳蕊.血清胆红素与尿酸检测对冠心病患者临床检验的价值研究[J].医学信息,2024,37(16):145.[doi:10.3969/j.issn.1006-1959.2024.16.034]
　LI Quan,ZENG Li-hong,ZENG Yan-rui.Study on the Value of Serum Bilirubin and Uric Acid Detection in Clinical Examination of Patientswith Coronary Heart Disease[J].Journal of Medical Information,2024,37(02):145.[doi:10.3969/j.issn.1006-1959.2024.16.034]

更新日期/Last Update: 1900-01-01