[1]唐娟娟,高春岭,秦凤琴.蒙特利尔认知评估量表在成都市郫都区老年性痴呆筛查中的应用分析[J].医学信息,2018,31(19):12-14.[doi:10.3969/j.issn.1006-1959.2018.19.004]
　TANG Juan-juan,GAO Chun-ling,QIN Feng-qin.Application Analysis of Montreal Cognitive Assessment Scale in Screening for Alzheimer’s Disease in Pidu District,Chengdu[J].Medical Information,2018,31(19):12-14.[doi:10.3969/j.issn.1006-1959.2018.19.004]
点击复制

蒙特利尔认知评估量表在成都市郫都区老年性痴呆筛查中的应用分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年19期
页码:
12-14
栏目:
出版日期:
2018-10-01

文章信息/Info

Title:
Application Analysis of Montreal Cognitive Assessment Scale in Screening for Alzheimer’s Disease in Pidu District,Chengdu
文章编号:
1006-1959（2018）19-0012-03
作者:
唐娟娟; 高春岭; 秦凤琴
成都市郫都区人民医院神经内科，四川 成都 611730
Author(s):
TANG Juan-juan; GAO Chun-ling; QIN Feng-qin
Department of Neurology,Chengdu Pidu District People’s Hospital,Chengdu 611730,Sichuan,China
关键词:
蒙特利尔认知评估量表; 阿尔茨海默病; 社区
Keywords:
Montreal Cognitive Assessment Scale; Alzheimer’s Disease; Community
分类号:
R749.1
DOI:
10.3969/j.issn.1006-1959.2018.19.004
文献标志码:
A
摘要:
目的 探讨成都市郫都区老年人AD的患病现状以及MoCA在社区老年痴呆的筛查中应用的可行性，探讨最佳分界值，评价其信效度及对AD的敏感性和特异性。方法 采用MMSE和MoCA对成都市郫都区老年人进行AD筛查，计算调查人群AD检出率，分析AD的影响因素。并对MoCA的信度、效度、敏感性、特异性和Youden指数进行分析，计算出适合我市老年人AD患者的划界分值。结果 通过对588人筛查出AD患者22人，总检出率为3.74%。MoCA的Cronbach’s α为0.766。本研究显示教育程度、年龄、性别、职业对AD的影响均较显著（P＜0.01）。MoCA用于AD的筛查敏感性为100.00%，特异性为99.39%。结论 成都市郫都区地区老年人AD检出率高，教育程度是AD的保护性因素，高龄是AD的危险因素；用MoCA量表对社区老年人认知功能的筛查是简便可行的，具有良好的信度、效度和敏感性。本研究推荐以15分作为我市社区老年人AD的分界值。
Abstract:
Objective To investigate the prevalence of AD in elderly people in Pidu district of Chengdu and the feasibility of using MoCA in the screening of community dementia,to explore the optimal cut-off value,evaluate its reliability and validity,and sensitivity and specificity to AD.Methods MMSE and MoCA were used to screen AD in the elderly in Chengdu,and the detection rate of AD was calculated and the influencing factors of AD were analyzed.The reliability,validity,sensitivity,specificity and Youden index of MoCA were analyzed to calculate the demarcation score suitable for AD patients in our city.Results By screening 588 people for 22 patients with AD,the total detection rate was 3.74%.MoCA’s Cronbach’s alpha is 0.766.This study showed that education,age,gender,and occupation had significant effects on AD(P<0.01).The screening sensitivity of MoCA for AD was 100.00% and the specificity was 99.39%.Conclusion The detection rate of AD was high in the elderly in Pidu district of Chengdu,and the educational level was the protective factor of AD,and the old age was the risk factor of AD.It was simple and feasible to screen the cognitive function of the elderly in the community with MoCA scale, and had good reliability,validity and sensitivity.This study recommended 15 points as the boundary value of AD in our community.

参考文献/References:

[1]Kim SJ,Moon GJ,Bang OY.Biomarker for stroke[J].J Stroke,2013,15(1):27-37. [2]Tuma RF,Steffens S.Targeting the endocannabinod system to limit myocardial and cerebral ischemic and reperfusion injury[J].Curr Pharm Biotechnol,2012,13(1):46-58. [3]Ishibashi N,Prokopenko O,Reuhl KR,et al.Inflammatory response and glutathione peroxidase in a model of stroke[J].J Immunol,2002,168(4):1926-1933. [4]Sharp FR,Zhan X,Liu DZ.Heat shock proteins in the brain: role of Hsp70, Hsp 27,and HO-1 (Hsp32) and their therapeutic potential[J].Transl Stroke Res,2013,4(6):685-692. [5]周银燕,邵建林,赵国良,等.内源性CO和NO在大鼠脑缺血-再灌注损伤中的作用[J].中华麻醉学杂志2011,27(1):404-407. [6]Meng YC,Ding ZY,Wang HQ,et al.Effect of microRNA-155 on angiogenesis after cerebral infarction of rats through AT1R/VEGFR2 pathway[J].Asian Pacific Journal of Tropical Medicine,2015,8(10):829-835. [7]Bharucha AE,Kullkarni A,Choi KM,et al.First-in-human study denonstrating pharmacological activation of heme oxygenase-1 in humans[J].Clin Pharamacel Ther,2010,87(2):187-190. [8]邵建林,万晓红,王雁,等.HO-1在七氟烷预处理抑制大鼠氧糖剥夺海马神经元凋亡中的作用[J].中华麻醉学杂志,2010,30(4):484-487. [9]Zhang M,Wang S,Mao L,et al.Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf 2 and upregulating heme oxygenase 1[J].J Neurosci,2014,34(5):1903-1915. [10]Yang Y,Wang J,Li Y,et al.HO-1 Signaling Activation by Pterostilbene Treatment Attenuates Mitochondrial Oxidative Damage Induced by Cerebral Ischemia Reperfusion Injury[J].Mol Neurobiol,2016,53(4):2339-2353.

相似文献/References:

[1]刘 璐,秦新月.阿尔茨海默病患者血尿酸水平变化的研究[J].医学信息,2018,31(02):96.[doi:10.3969/j.issn.1006-1959.2018.02.033]
　LIU Lu,QIN Xin-yue.Study on the Changes of Serum Uric Acid in Alzheimer 's Disease Patients[J].Medical Information,2018,31(19):96.[doi:10.3969/j.issn.1006-1959.2018.02.033]
[2]赖 超,成官迅.rs-fMRI、DTI及1H-MRS在阿尔茨海默病中的应用进展[J].医学信息,2018,31(13):41.[doi:10.3969/j.issn.1006-1959.2018.13.013]
　LAI Chao,CHENG Guan-xun.Application of rs-fMRI、DTI and 1H-MRS in Alzheimer’s Disease[J].Medical Information,2018,31(19):41.[doi:10.3969/j.issn.1006-1959.2018.13.013]
[3]张 辉,张 颖.多奈哌齐联合司来吉兰对阿尔茨海默病患者认知功能及不良反应的影响[J].医学信息,2022,35(13):110.[doi:10.3969/j.issn.1006-1959.2022.13.024]
　ZHANG Hui,ZHANG Ying.Effect of Donepezil Combined with Selegilan on Cognitive Function and Adverse Reactions in Patients with Alzheimer’s Disease[J].Medical Information,2022,35(19):110.[doi:10.3969/j.issn.1006-1959.2022.13.024]
[4]杨联勇,沈金娥.阿尔茨海默病新药的临床实验研究[J].医学信息,2020,33(02):50.[doi:10.3969/j.issn.1006-1959.2020.02.014]
　YANG Lian-yong,SHEN Jin-e.Clinical Experimental Study of New Drugs for Alzheimer’s Disease[J].Medical Information,2020,33(19):50.[doi:10.3969/j.issn.1006-1959.2020.02.014]
[5]康晨瑶,刘 洲,周海红.NLRP3炎症小体在AD发病机制中的作用[J].医学信息,2021,34(12):40.[doi:10.3969/j.issn.1006-1959.2021.12.011]
　KANG Chen-yao,LIU Zhou,ZHOU Hai-hong.The Role of NLRP3 Inflammasome in the Pathogenesis of AD[J].Medical Information,2021,34(19):40.[doi:10.3969/j.issn.1006-1959.2021.12.011]
[6]韦春英,莫颖敏.阿尔茨海默病早期诊断的脑脊液和血液生物标志物研究[J].医学信息,2021,34(14):25.[doi:10.3969/j.issn.1006-1959.2021.14.007]
　WEI Chun-ying,MO Ying-min.Study on Cerebrospinal Fluid and Blood Biomarkers for Early Diagnosis of Alzheimer’s Disease[J].Medical Information,2021,34(19):25.[doi:10.3969/j.issn.1006-1959.2021.14.007]
[7]于京虎.复方脑肽节苷脂联合多奈哌齐对阿尔茨海默病患者认知功能及SOD水平的影响[J].医学信息,2023,36(03):148.[doi:10.3969/j.issn.1006-1959.2023.03.031]
　YU Jing-hu.Effect of Compound Porcine Cerebroside and Ganglioside Combined with Donepezil on Cognitive Function and SOD Level in Patients with Alzheimer’s Disease[J].Medical Information,2023,36(19):148.[doi:10.3969/j.issn.1006-1959.2023.03.031]
[8]张 瑞,延沁儒.丹酚酸B调节Bax/Bcl-2的表达对阿尔茨海默病小鼠认知功能的影响及机制[J].医学信息,2021,34(17):70.[doi:10.3969/j.issn.1006-1959.2021.17.018]
　ZHANG Rui,YAN Qin-ru.Effects of Salvianolic Acid B on the Cognitive Function of Alzheimer’s Disease Mice and its Mechanism Regulating the Expression of Bax/Bcl-2[J].Medical Information,2021,34(19):70.[doi:10.3969/j.issn.1006-1959.2021.17.018]
[9]徐 静.综合康复护理对阿尔兹海默病患者认知功能及生活能力的影响[J].医学信息,2023,36(04):150.[doi:10.3969/j.issn.1006-1959.2023.04.031]
　XU Jing.Effect of Comprehensive Rehabilitation Nursing on Cognitive Function and Living Ability of Patients with Alzheimer’s Disease[J].Medical Information,2023,36(19):150.[doi:10.3969/j.issn.1006-1959.2023.04.031]
[10]陈浩宇,张 淼,张德锦,等.基于数据挖掘技术分析穴位按摩治疗阿尔茨海默病的选穴规律[J].医学信息,2023,36(08):7.[doi:10.3969/j.issn.1006-1959.2023.08.002]
　CHEN Hao-yu,ZHANG Miao,ZHANG De-jin,et al.Analysis of Acupoint Selection Rules in Treating Alzheimer’s Disease with Acupoint Massage Based on Data Mining[J].Medical Information,2023,36(19):7.[doi:10.3969/j.issn.1006-1959.2023.08.002]

更新日期/Last Update: 2018-10-29