[1]陈学敏,彭 琼.中性粒细胞与淋巴细胞比值联合癌胚抗原对结直肠癌早期诊断的研究[J].医学信息,2019,32(02):75-78.[doi:10.3969/j.issn.1006-1959.2019.02.022]
　CHEN Xue-min,PENG Qiong.Early Diagnosis of Colorectal Cancer by Neutrophil-lymphocyte Ratio Combined with Carcinoembryonic Antigen[J].Journal of Medical Information,2019,32(02):75-78.[doi:10.3969/j.issn.1006-1959.2019.02.022]
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中性粒细胞与淋巴细胞比值联合癌胚抗原对结直肠癌早期诊断的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年02期
页码:
75-78
栏目:
论著
出版日期:
2019-01-15

文章信息/Info

Title:
Early Diagnosis of Colorectal Cancer by Neutrophil-lymphocyte Ratio Combined with Carcinoembryonic Antigen
文章编号:
1006-1959（2019）02-0075-04
作者:
陈学敏; 彭 琼
安徽医科大学第三附属医院消化内科，安徽 合肥 230061
Author(s):
CHEN Xue-min; PENG Qiong
Department of Gastroenterology,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,Anhui,China
关键词:
中性粒细胞与淋巴细胞比值; 癌胚抗原; 结直肠癌; 早期诊断
Keywords:
Neutrophil to lymphocyte ratio; Carcinoembryonic antigen; Colorectal cancer; Early diagnosis
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2019.02.022
文献标志码:
A
摘要:
目的 探讨应用外周血中性粒细胞与淋巴细胞比值（NLR）联合癌胚抗原（CEA）对结直肠癌早期诊断的意义。方法 选取2016年1月~2018年1月来我院初治的结直肠癌患者103例为研究组，选取同期我院147例结直肠腺瘤性息肉患者为息肉组，体检中心150例健康体检者为对照组。通过受试者工作特征曲线（ROC曲线）测定NLR诊断结直肠癌的临界值，并与CEA联合诊断判断NLR联合CEA对提高结直肠癌的诊断的特异度及敏感度是否有优势。结果 研究组中性粒细胞、NLR和CEA的表达量高于息肉组和对照组（P＜0.05）
Abstract:
Objective To investigate the significance of peripheral blood neutrophil-to-lymphocyte ratio (NLR) combined with carcinoembryonic antigen (CEA) in the early diagnosis of colorectal cancer. Methods A total of 103 patients with colorectal cancer who were admitted to our hospital from January 2016 to January 2018 were enrolled in the study group. A total of 147 patients with colorectal adenomatous polyps in the same period were enrolled in the polyp group, and 150 physical examinations in the physical examination center. The control group. NLR was used to determine the critical value of colorectal cancer by receiver operating characteristic curve (ROC curve), and combined with CEA to determine whether NLR combined with CEA has an advantage in improving the specificity and sensitivity of colorectal cancer diagnosis. Results The expression of neutrophil, NLR and CEA in study group was higher than that in polyp group and control group (P<0.05). The expression of lymphocytes in the control group was higher than that in the study group and polyp group, and the expression of NLR and CEA in the polyp group was higher than that in the control group (P<0.05), and the expression of NLR and CEA in the polyp group was higher than that in the control group (P<0.05).The best cut-off value of NLR for the diagnosis of colorectal cancer by ROC curve was 1.760, the sensitivity was 83.13%, the specificity was 62.00% and the AUC was 0.80,95% CI is 0.75~0.86. The sensitivity of NLR combined with CEA in the diagnosis of colorectal cancer was 75.90%, the specificity was 93.35%, the AUC was 0.89, and the 95% CI was 0.84~0.94. Conclusion The application of NLR has a high sensitivity and specificity for the diagnosis of colorectal cancer. Therefore, when NLR is combined with CEA diagnosis, the sensitivity and specificity of early colorectal cancer will be improved.

参考文献/References:

[1]杨姣,傅健飞,袁瑛,等.老年结直肠癌的临床病理特征和预后[J].实用肿瘤杂志,2018,33(3):228-233.
[2]Yilmazlar T,Zorluoglu A,Ozgüg H,et al.Colorectal cancer in young adults[J].Dig Dis Sci,2015,74(3):920-924.
[3]Yan WJ,Guo MZ.Epigenetics of colorectal cancer[J].Springer New York,2015,1238(1238):405-424.
[4]Coffelt SB,Wellenstein MD,de Visser KE.Neutrophils in cancer:neutral no more[J].Nat Rev Cancer,2016,16(7):431-446.
[5]Eo WK,Chang HJ,Kwon SH,et al.The lymphocyte-monocyte ratio predicts patient survival and aggressiveness of ovarian cancer[J].J Cancer,2016(7):289-296.
[6]Siegel RL,Miller KD,Jemal A.Cancer statistics,2015[J].CA Cancer J Clin,2015,65(1):5-29.
[7]Meester RG,Doubeni CA,Lansdorp-Vogelaar I,et al.Colorectal cancer deaths attributable to nonuse of screening in the United States[J].Ann Epidemiol,2015,25(3):208-213.
[8]Yuan P,Gu J.Meta-analysis of the compliance of colorectal cancer screening in China,2006~2015[J].China Cancer,2017,26(4):241-248.
[9]Huo YR,Huang Y,Liauw W,et al.Prognostic value of carcinoembryonic antigen (CEA),AFP,CA19-9 and CA125 for patients with colorectal cancer with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy[J].Anticancer Res,2016,36(3):1041-1049.
[10]冯怡锟,蒋玉涵,刘维伟,等.371例结直肠息肉患者临床特征及其与粪便隐血和血CEA之间的关系[J].重庆医学,2018,47(9):1183-1185.
[11]程卫,邱辉忠.结直肠癌的分子生物学诊断进展[J].癌症进展,2013,11(1):24-30.
[12]Li Y,Wang C,Xu M,et al.Preoperative NLR for predicting survival rate after radical resection combined with adjuvant immunotherapy with CIK and postoperative chemotherapy in gastric cancer[J].J Cancer Res Clin Oncol,2017,143(5):861-871
[13]Treffers LW,Hiemstra IH,Kuijpers TW,et al.Neutrophils in cancer[J].Immunol Rev,2016,273(1):312-328.
[14]Qi Q,Geng Y,Sun M,et al.Clinical implications of systemic inflammatory response markers as Independent prognostic factors for advanced pancreatic cancer[J].Pancreatology,2015,15(2):145-150.
[15]Ucmak F,Tuncel ET,et al.Relationship between lesions in adenomatous polyp-dysplasia-colorectal cancer sequence and neutrophil-to-lymphocyte ratio[J].Med Sci Monit,2016,24(22):4536-4541.
[16]Zhan X,Sun X,Hong Y,et al.Combined detection of preoperative neutrophil-to-lymphocyte ratio and CEA as an independent prognostic factor in nonmetastatic patients undergoing colorectal cancer resection is superior to NLR or CEA alone[J].Biomed ResInt,2017(8):3809464.

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更新日期/Last Update: 2019-02-15