[1]桑星晨.黄芩的化学成分及治疗阿尔兹海默病的研究进展[J].医学信息,2019,32(13):52-55.[doi:10.3969/j.issn.1006-1959.2019.13.016]
　SANG Xing-chen.Advances in Research on Chemical Constituents of Astragalus and Treatment of Alzheimer's Disease[J].Journal of Medical Information,2019,32(13):52-55.[doi:10.3969/j.issn.1006-1959.2019.13.016]
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黄芩的化学成分及治疗阿尔兹海默病的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年13期
页码:
52-55
栏目:
综述
出版日期:
2019-07-01

文章信息/Info

Title:
Advances in Research on Chemical Constituents of Astragalus and Treatment of Alzheimer's Disease
文章编号:
1006-1959（2019）13-0052-04
作者:
桑星晨
上海中医药大学基础医学院，上海 200120
Author(s):
SANG Xing-chen
School of Basic Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China
关键词:
黄芩; 阿尔兹海默病; 神经退行性疾病
Keywords:
Key words：Astragalus; Alzheimer's disease; Neurodegenerative diseases
分类号:
R285.5
DOI:
10.3969/j.issn.1006-1959.2019.13.016
文献标志码:
A
摘要:
阿尔茨海默病是一种神经系统退行性疾病，中医称之为“痴呆”，其发病机制复杂，普遍认为主要有β-淀粉样蛋白（Aβ）过度沉积、神经炎症反应、Tau蛋白过度磷酸化等，目前临床还没有找到有效的治疗药物。黄芩的化学成分复杂，作用广泛，研究发现其主要有效成分黄酮类化合物黄芩苷、黄芩素等可改善神经退行性疾病，具有潜在的治疗阿尔兹海默病的发展前景。本文对黄芩的化学成分及治疗阿尔兹海默病的机制作一综述。
Abstract:
Abstract：Alzheimer's disease is a degenerative disease of the nervous system. It is called "dementia" by traditional Chinese medicine. Its pathogenesis is complex. It is generally believed that there are mainly β-amyloid (Aβ) excessive deposition, neuroinflammatory reaction, and Tau protein. Excessive phosphorylation, etc., currently no effective therapeutic drugs have been found in the clinic. Astragalus has a complex chemical composition and a wide range of functions. It has been found that its main active constituents, flavonoids baicalin and baicalein, can improve neurodegenerative diseases and have potential development prospects for the treatment of Alzheimer's disease. This article reviews the chemical composition of Astragalus and the mechanism for the treatment of Alzheimer's disease.

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更新日期/Last Update: 2019-07-01