[1]蒋峰丽,马亚楠,乌 丽.胎盘生长因子在子痫前期早期诊断中的临床价值[J].医学信息,2019,32(16):160-162.[doi:10.3969/j.issn.1006-1959.2019.16.054]
　JIANG Feng-li,MA Ya-nan,WU Li.Clinical Value of Placental Growth Factor in Early Diagnosis of Preeclampsia[J].Journal of Medical Information,2019,32(16):160-162.[doi:10.3969/j.issn.1006-1959.2019.16.054]
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胎盘生长因子在子痫前期早期诊断中的临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年16期
页码:
160-162
栏目:
诊疗技术
出版日期:
2019-08-15

文章信息/Info

Title:
Clinical Value of Placental Growth Factor in Early Diagnosis of Preeclampsia
文章编号:
1006-1959（2019）16-0160-03
作者:
蒋峰丽1; 马亚楠2; 乌 丽1
1.中国医学科学院整形外科医院检验科，北京 100043； 2.天津市第三中心医院检验科，天津 300170
Author(s):
JIANG Feng-li1; MA Ya-nan2; WU Li1
1.Department of Clinical Laboratory,Chinese Academy of Medical Sciences Plastic Surgery Hospital,Beijing 100043,China; 2.Department of Clinical Laboratory,Tianjin Third Central Hospital,Tianjin 300170,China
关键词:
子痫前期; 胎盘生长因子; 灵敏度; 特异度
Keywords:
Key words：Preeclampsia; Placental growth factor; Sensitivity; Specificity
分类号:
R714.24+4
DOI:
10.3969/j.issn.1006-1959.2019.16.054
文献标志码:
A
摘要:
目的 探讨外周血浆中胎盘生长因子（PLGF）对子痫前期（PE）患者的早期预测意义。方法 选取天津市第三中心医院收治的105例正常妊娠妇女（对照组）、69例轻度PE患者（轻度组）及54例重度PE患者（重度组）为研究对象，采用荧光免疫分方法测定血浆中PLGF的浓度。使用ROC曲线分析PLGF，预测PE发生的灵敏度和特异度。结果 重度组患者血清PIGF水平低于轻度组和对照组，且轻度组低于对照组，差异均有统计学意义（P＜0.05）。ROC曲线分析显示，血清PIGF水平在预测PE发生中，曲线下面积0.962（95%CI：0.921~1.000，P＜0.05），取截点值47.5 pg/ml，特异度为0.907，敏感度为0.900。结论 PE患者外周血PLGF水平明显降低，PLGF水平与疾病严重程度呈负相关，PLGF或许可以作为早期筛选PE患者的方法之一，预防和控制PE，为母婴安全提供帮助。
Abstract:
Abstract：Objective To investigate the early predictive value of placental plasma growth factor (PLGF) in patients with preeclampsia (PE).Methods A total of 105 normal pregnant women (control group), 69 patients with mild PE (mild group) and 54 patients with severe PE (severe group) were enrolled in the Third Central Hospital of Tianjin. The concentration of PLGF in plasma was measured. The PLGF was analyzed using the ROC curve to predict the sensitivity and specificity of PE occurrence.Results Serum PIGF levels in the severe group were lower than those in the mild group and the control group, and the mild group was lower than the control group, the difference was statistically significant (P<0.05). ROC curve analysis showed that serum PIGF level in the prediction of PE occurred, the area under the curve was 0.962 (95% CI: 0.921~1.000, P<0.05), the cut-off point value was 47.5 pg/ml, the specificity was 0.907, and the sensitivity was 0.900.Conclusion The level of PLGF in peripheral blood of PE patients is significantly decreased. The level of PLGF is negatively correlated with the severity of disease. PLGF may be one of the methods for early screening of PE patients to prevent and control PE and provide help for maternal and child safety.

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更新日期/Last Update: 2019-08-15