[1]陈晓娆,杨志雄,苏文媚,等.lncRNA在非小细胞肺癌中的研究[J].医学信息,2020,33(12):24-26.[doi:10.3969/j.issn.1006-1959.2020.12.009]
 CHEN Xiao-rao,YANG Zhi-xiong,SU Wen-mei,et al.Study of lncRNA in Non-small Cell Lung Cancer[J].Medical Information,2020,33(12):24-26.[doi:10.3969/j.issn.1006-1959.2020.12.009]
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lncRNA在非小细胞肺癌中的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年12期
页码:
24-26
栏目:
综述
出版日期:
2020-06-15

文章信息/Info

Title:
Study of lncRNA in Non-small Cell Lung Cancer
文章编号:
1006-1959(2020)12-0024-03
作者:
陈晓娆杨志雄苏文媚
(1.广东医科大学,广东 湛江 524000;2.广东医科大学附属医院肿瘤科,广东 湛江 524000)
Author(s):
CHEN Xiao-raoYANG Zhi-xiongSU Wen-meiet al
(1.Guangdong Medical University,Zhanjiang 524000,Guangdong,China;2.Department of Oncology,the Affiliated Hospital of Guangdong Medical University,Zhanjiang524000,Guangdong,China)
关键词:
长链非编码RNA非小细胞肺癌耐药放射敏感性
Keywords:
Long-chain noncoding RNANon-small cell lung cancerDrug resistanceRadiosensitivity
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2020.12.009
文献标志码:
A
摘要:
肺癌是全球最常见的恶性肿瘤之一,发病率和死亡率均位居第一。长链非编码RNA(lncRNA)是一种至少长200 nt且没有蛋白质编码作用的RNA,可以发挥多种生物学功能。研究表明,多种lncRNA能够促进或抑制非小细胞肺癌(NSCLC)的发生和进展,并且能影响其疗效如放疗、化疗及靶向治疗,lncRNA在NSCLC中的作用机制有助于NSCLC的恶性程度诊断、疗效预测及预后,并且有望成为新的肿瘤标志物。本文现就lncRNA在NSCLC中的作用及其对NSCLC治疗的影响及治疗靶点的意义进行总结。
Abstract:
Lung cancer is one of the most common malignant tumors in the world, with morbidity and mortality ranking first. Long-chain non-coding RNA (lncRNA) is an RNA that is at least 200 nt long and has no protein-coding effect, and can perform various biological functions. Studies have shown that a variety of lncRNA can promote or inhibit the occurrence and progression of non-small cell lung cancer (NSCLC), and can affect its efficacy such as radiotherapy, chemotherapy and targeted therapy. The mechanism of lncRNA in NSCLC contributes to the malignant degree of NSCLC Diagnosis, efficacy prediction and prognosis, and is expected to become a new tumor marker. This article summarizes the role of lncRNA in NSCLC for now, its impact on NSCLC treatment, and the significance of therapeutic targets.

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更新日期/Last Update: 1900-01-01