[1]张艺博,文 静,何 燕.长爪沙鼠氧化应激水平与血糖及胰岛素抵抗的相关性分析[J].医学信息,2021,34(12):1-4.[doi:10.3969/j.issn.1006-1959.2021.12.001]
　ZHANG Yi-bo,WEN Jing,HE Yan.Correlation Analysis of Oxidative Stress Level with Blood Sugar and Insulin Resistance in Eriones Unguiculatus[J].Medical Information,2021,34(12):1-4.[doi:10.3969/j.issn.1006-1959.2021.12.001]
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长爪沙鼠氧化应激水平与血糖及胰岛素抵抗的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年12期
页码:
1-4
栏目:
出版日期:
2021-06-15

文章信息/Info

Title:
Correlation Analysis of Oxidative Stress Level with Blood Sugar and Insulin Resistance in Eriones Unguiculatus
文章编号:
1006-1959（2021）12-0001-04
作者:
张艺博; 文 静; 何 燕
（首都医科大学公共卫生学院流行病与卫生统计学系，北京 100069）
Author(s):
ZHANG Yi-bo; WEN Jing; HE Yan
(Department of Epidemiology and Biostatistics,School of Public Health,Capital Medical University,Beijing 100069,China)
关键词:
长爪沙鼠; 氧化应激; 胰岛素抵抗; 骨骼肌
Keywords:
Eriones unguiculatus; Oxidative stress; Insulin resistance; Skeletal muscle
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2021.12.001
文献标志码:
A
摘要:
目的 探讨长爪沙鼠氧化应激指标与血糖、胰岛素抵抗、骨骼肌指标的关系，明确氧化应激与糖尿病之间的相互作用。方法 选取长爪沙鼠145只，测量体重；摘眼球取血检测空腹血糖（FPG）、空腹胰岛素（FIN）、超氧化物歧化酶（SOD）；取腓肠肌检测腓肠肌重量及腓肠肌内的糖原储存；计算稳态模型胰岛素抵抗指数（HOMA-IR）以及定量胰岛素敏感性检测指数（QUICKI），并对氧化应激与血糖、胰岛素抵抗指标、骨骼肌指标进行Spearman相关性分析及多元线性回归分析。结果 ①不同月龄间长爪沙鼠SOD活性比较，差异有统计学意义（P＜0.05），且3~18月龄间长爪沙鼠SOD水平逐渐升高，18~24月龄间长爪沙鼠SOD水平有所降低；Spearman相关性分析显示，月龄和SOD活性水平呈正相关（r=0.361，P＜0.05）；多元线性回归分析显示，月龄与SOD水平存在关联，即随着月龄的增加，SOD水平升高。②不同月龄间长爪沙鼠FPG、HOMA-IR、QUICKI比较，差异有统计学意义（P＜0.05）；Spearman相关分析显示，月龄与胰岛素抵抗指数呈负相关（r=-0.303，P＜0.05），与胰岛素敏感性呈正相关（r=0.303，P＜0.05），月龄与空腹血糖无相关性（r=-0.051，P＞0.05）；多元线性回归分析显示，SOD与FPG、胰岛素敏感性存在关联，即随着SOD水平升高，氧化水平降低，空腹血糖降低，胰岛素敏感性升高。③不同月龄长爪沙鼠骨骼肌质量、骨骼肌糖原储存比较，差异有统计学意义（P＜0.05）；相关性及多元线性分析均显示SOD水平与骨骼肌质量、骨骼肌糖原无相关性。结论 氧化应激与胰岛素抵抗存在关联，但与骨骼肌指标间的关联证据不足。
Abstract:
Objective To explore the relationship between oxidative stress indicators and blood glucose, insulin resistance, and skeletal muscle indicators in eriones unguiculatus, and to clarify the interaction between oxidative stress and diabetes.Methods A total of 145 eriones unguiculatus were selected and their weights were measured; the eyes were removed and blood was taken to detect fasting blood glucose (FPG), fasting insulin (FIN), and superoxide dismutase(SOD);The gastrocnemius muscle was taken to measure the weight of the gastrocnemius muscle and the glycogen storage in the gastrocnemius; the homeostasis model insulin resistance index (HOMA-IR) and the quantitative insulin sensitivity test index (QUICKI) were calculated, and the oxidative stress and blood glucose, insulin resistance indicators, and skeletal muscle were calculated. Spearman correlation analysis and multiple linear regression analysis were performed on the indicators.Results ①There was a statistically significant difference in the SOD activity of eriones unguiculatus between different months of age(P＜0.05).The SOD level of eriones unguiculatus gradually increased from 3 to 18 months of age, and the SOD level of gerbils from 18 to 24 months of age decreased. Spearman correlation analysis showed that month age and SOD activity levels were positively correlated(r=0.361, P＜0.05);Multiple linear regression analysis showed that there was a correlation between the age of the month and the level of SOD, that was, as the age of the month increased, the level of SOD increased.②Comparison of FPG, HOMA-IR, and QUICKI of Mongolian gerbils between different months of age, the difference was statistically significant(P<0.05);Spearman correlation analysis showed that month age was negatively correlated with insulin resistance index(r=-0.303,P＜0.05), and positively correlated with insulin sensitivity(r=0.303, P＜0.05).There was no correlation between month age and fasting blood glucose(r=-0.051, P>0.05);Multiple linear regression analysis showed that SOD is associated with FPG and insulin sensitivity, that was, as SOD levels increased, oxidation levels decreased, fasting blood glucose decreased, and insulin sensitivity increased.③Comparing the skeletal muscle mass and skeletal muscle glycogen storage of eriones unguiculatus at different months of age, the difference was statistically significant (P＜0.05);Correlation and multivariate linear analysis showed that there was no correlation between SOD level and skeletal muscle mass and skeletal muscle glycogen.Conclusion There is an association between oxidative stress and insulin resistance, but there is insufficient evidence for the association with skeletal muscle indicators.

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更新日期/Last Update: 1900-01-01