[1]汤 旭,胡雪莉,邱德稳.江西地区女性不孕患者生殖道支原体感染特点及耐药性分析[J].医学信息,2021,34(12):159-161.[doi:10.3969/j.issn.1006-1959.2021.12.043]
　TANG Xu,HU Xue-li,QIU De-wen.Analysis of the Characteristics of Genital Mycoplasma Infection and Drug Resistance in Female Infertile Patients in Jiangxi[J].Medical Information,2021,34(12):159-161.[doi:10.3969/j.issn.1006-1959.2021.12.043]
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江西地区女性不孕患者生殖道支原体感染特点及耐药性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年12期
页码:
159-161
栏目:
调查分析
出版日期:
2021-06-15

文章信息/Info

Title:
Analysis of the Characteristics of Genital Mycoplasma Infection and Drug Resistance in Female Infertile Patients in Jiangxi
文章编号:
1006-1959（2021）12-0159-03
作者:
汤 旭; 胡雪莉; 邱德稳
（江西省妇幼保健院检验科，江西 南昌 330000）
Author(s):
TANG Xu; HU Xue-li; QIU De-wen
(Department of Laboratory Medicine,Jiangxi Maternal and Child Health Hospital,Nanchang 330000,Jiangxi,China)
关键词:
支原体感染; 不孕; 耐药性
Keywords:
Mycoplasma infection; Infertility; Drug resistance
分类号:
R969.4
DOI:
10.3969/j.issn.1006-1959.2021.12.043
文献标志码:
A
摘要:
目的 了解江西地区女性不孕患者生殖道支原体感染特点及药敏情况，为临床合理用药提供指导。方法 选取2016年1月~2019年12月就诊于我院的26411例不孕患者作为观察组，另选同期优生优育体检女性7718例作为对照组，取宫颈分泌物进行解脲脲原体（Uu）、人型支原体（Mh）鉴定及药敏试验。比较两组Uu单独感染、Mh单独感染和Uu+Mh混合感染阳性率及两组阳性标本对12种抗菌药物的耐药率。结果 不孕组支原体总阳性率、Uu+Mh混合感染率高于对照组，差异有统计学意义（P＜0.05）；两组Uu、Mh单独感染率比较，差异无统计学意义（P＞0.05）；生殖道支原体对环丙沙星耐药率最高，其次为红霉素和司巴沙星；对交沙霉素最为敏感，其次为美满霉素、强力霉素和四环素；除以上四种最敏感抗菌药物外，不孕组对各抗菌药物的耐药率均高于对照组，差异有统计学意义（P＜0.05）。结论 女性不孕患者生殖道支原体感染率较正常育龄妇女更高，主要表现为Uu+Mh混合感染率更高，且对于各抗菌药物耐药率更高。临床治疗时应根据药敏结果选择抗菌药物，其中交沙霉素、美满霉素、强力霉素可作为首选药物。
Abstract:
Objective To understand the characteristics of genital mycoplasma infection and drug sensitivity in female infertile patients in Jiangxi, and provide guidance for clinical rational use of drugs.Methods 26,411 infertile patients who were admitted to our hospital from January 2016 to December 2019 were selected as the observation group.In addition, 7718 women with prenatal and postnatal physical examination during the same period were selected as the control group, and the cervical secretions were taken for the identification of Ureaplasma Urealyticum (Uu) and Mycoplasma hominis (Mh) and drug sensitivity test.The positive rates of Uu alone infection, Mh alone infection and Uu+Mh mixed infection between the two groups were compared, and the resistance rates of the two groups of positive specimens to 12 antibacterial drugs were compared.Results The total positive rate of mycoplasma and the mixed infection rate of Uu+Mh in the infertility group were higher than those in the control group,the difference was statistically significant (P<0.05);There was no statistically significant difference in Uu and Mh infection rates between the two groups (P>0.05);Mycoplasma genitalium had the highest resistance rate to ciprofloxacin, followed by erythromycin and sparfloxacin; the most sensitive to josamycin, followed by minocycline, doxycycline and tetracycline;Except for the above four most sensitive antibacterial drugs, the resistance rate of each antibacterial drug in the infertility group was higher than that of the control group,the difference was statistically significant (P<0.05).Conclusion The infection rate of mycoplasma in the genital tract of female infertility patients is higher than that of normal women of childbearing age, mainly due to the higher rate of Uu+Mh mixed infection and higher rate of resistance to various antimicrobial drugs.In clinical treatment, antibacterial drugs should be selected according to the results of drug sensitivity, among which josamycin, minocycline, and doxycycline can be the first choice.

参考文献/References:

[1]Katie MM,Andrew B,Clare N,et al.Severe Mycoplasma pneumoniae Infection in Children Admitted to Pediatric Intensive Care[J].The Pediatric Infectious Disease Journal,2018,37(12):e336-e338. [2]Henthorn CR,Chris Minion F,Sahin O.Utilization of macrophage extracellular trap nucleotides by Mycoplasma hyopneumoniae[J].Microbiology,2018,164(11):1394-1404. [3]Leli C,Mencacci A,Latino MA,et al.Prevalence of cervical colonization by Ureaplasma parvum,Ureaplasma urealyticum,Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR:An Italian observational multicentre study[J].J Microbiol Immunol Infect,2018,51(2):220-225. [4]Dana MH,Sahnzi CM,Johanel C,et al.Characterization of unilateral conjunctival inoculation with Mycoplasma gallisepticum in house finches[J].Avian Pathology,2018,47(5):526-530. [5]中国医师协会生殖医学专业委员会.高龄女性不孕诊治指南[J].中华生殖与避孕杂志,2017,37(2):87-100. [6]尚红等.全国临床检验操作规程[M].北京:人民卫生出版社,2015:196-197. [7]程玲,颜晓红,李友筑,等.不孕患者生殖道支原体感染及药敏结果分析[J].中国妇幼保健,2020,35(8):1490-1492. [8]曹仁康,王露娟,杨靖,等.某生殖中心就诊不孕患者支原体感染及其药物敏感性研究[J].中华医院感染学杂志,2019,29(22):3469-3472. [9]王晓娜,丛桂敏,曹作伟,等.连续5年沈阳地区生殖道支原体感染监测及耐药性变迁[J].当代医学,2020,26(6):20-23. [10]贾双荣,胡萌,蒋琳华,等.重庆地区4414例泌尿生殖道支原体检测及药敏分析[J].重庆医学,2017,46(5):609-611. [11]杨葵,钟敏.解脲和人型支原体固体培养检测及抗生素研究[J].国际泌尿系统杂志,2019,39(2):274-277.

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