[1]郭志丽,刘改莲,贺 蓉.阿奇霉素、氨溴特罗联合肺力咳合剂对支原体感染患儿血常规及CRP水平的影响[J].医学信息,2023,36(09):124-127.[doi:10.3969/j.issn.1006-1959.2023.09.025]
　GUO Zhi-li,LIU Gai-lian,HE Rong.Effect of Azithromycin, Ambroxol Combined with Feilike Mixture on Blood Routine and CRP Level in Children with Mycoplasma Infection[J].Journal of Medical Information,2023,36(09):124-127.[doi:10.3969/j.issn.1006-1959.2023.09.025]
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阿奇霉素、氨溴特罗联合肺力咳合剂对支原体感染患儿血常规及CRP水平的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年09期
页码:
124-127
栏目:
论著
出版日期:
2023-05-01

文章信息/Info

Title:
Effect of Azithromycin, Ambroxol Combined with Feilike Mixture on Blood Routine and CRP Level in Children with Mycoplasma Infection
文章编号:
1006-1959（2023）09-0124-04
作者:
郭志丽; 刘改莲; 贺 蓉
（天津华兴医院儿科门诊，天津 300270）
Author(s):
GUO Zhi-li; LIU Gai-lian; HE Rong
(Pediatric Clinic of Tianjin Huaxing Hospital,Tianjin 300270,China)
关键词:
阿奇霉素; 氨溴特罗; 肺力咳合剂; 支原体感染; 血常规
Keywords:
Azithromycin; Ambroxol; Feilike mixture; Mycoplasma infection; Blood routine
分类号:
R563.15
DOI:
10.3969/j.issn.1006-1959.2023.09.025
文献标志码:
A
摘要:
目的 观察阿奇霉素、氨溴特罗联合肺力咳合剂对支原体感染患儿血常规及CRP水平的影响。方法 选取2019年2月-2020年2月我院诊治的76例支原体感染患儿为研究对象，采用随机数字表法分为对照组和观察组，各38例。对照组采用阿奇霉素联合氨溴特罗治疗，观察组在对照组基础上联合肺力咳合剂治疗，比较两组患儿临床症状消失时间、临床疗效、外周血白细胞和嗜酸性粒细胞计数、CRP水平、中医症状积分以及不良反应发生率。结果 观察组咳嗽、发热、气喘、肺部湿啰音消失时间均短于对照组，差异有统计学意义（P＜0.05）；观察组治疗总有效率为94.74%，高于对照组的81.58%，差异有统计学意义（P＜0.05）；两组治疗后外周血白细胞计数、嗜酸性粒细胞计数、CRP水平均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；两组治疗后中医症状积分低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）。结论 阿奇霉素、氨溴特罗联合肺力咳合剂治疗在支原体感染患儿中具有理想的治疗效果，可改善临床症状，减轻炎症反应，且不增加不良反应发生风险。
Abstract:
Objective To observe the effect of azithromycin and ambroxol combined with Feilike mixture on blood routine and CRP level in children with mycoplasma infection.Methods A total of 76 children with mycoplasma infection diagnosed and treated in our hospital from February 2019 to February 2020 were selected as the research objects. They were divided into control group and observation group by random number table method, with 38 cases in each group. The control group was treated with azithromycin combined with ambroxol, and the observation group was treated with Feilike mixture on the basis of the control group. The disappearance time of clinical symptoms, therapeutic effect, peripheral blood leukocyte and eosinophil count, CRP level, TCM symptom score and incidence of adverse reactions were compared between the two groups.Results The disappearance time of cough, fever, asthma and lung moist rale in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The total effective rate of treatment in the observation group was 94.74%, which was higher than 81.58% in the control group, and the difference was statistically significant (P<0.05). After treatment, the peripheral blood white blood cell count, eosinophil count and CRP level of the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The TCM symptom scores of the two groups after treatment were lower than those before treatment, and those in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).Conclusion Azithromycin, ambroxol combined with Feilike mixture has an ideal therapeutic effect in children with mycoplasma infection, which can improve clinical symptoms, reduce inflammatory reaction, and do not increase the risk of adverse reactions.

参考文献/References:

[1]蔡亲武,杨子江,王昌乐．阿奇霉素治疗小儿上呼吸道肺炎支原体感染临床效果观察[J].河北医学,2018,24(2):328-332．[2]Tsai TA,Tsai CK,Kuo KC,et al.Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children[J].J Microbiol Immunol Infect,2021,54(4):557-565.[3]刘阿玲,李红梅,李玲玲.麻杏石甘汤结合阿奇霉素治疗儿童支原体肺炎[J].国际中医中药杂志,2018,40(12):1125-1128.[4]许姜姜,舒林华.儿童难治性肺炎支原体肺炎临床特征分析[J].中国当代儿科杂志,2018,20(1):37-42.[5]王利玲,李春连,程申.宣氏小儿清肺糖浆联合阿奇霉素治疗小儿肺炎支原体肺炎痰热闭肺证60例临床观察[J].中医儿科杂志,2018,14(1):39-43.[6]李小容,唐川婷,高广川,等. MSCT联合血清MP-IgM、MP-Ab检测对小儿支原体感染肺炎有较高的诊断价值[J].分子影像学杂志,2022,45(3):378-381.[7]丁彩云,王梦瑾,孙立清.不同咽拭子取样肺炎支原体DNA检测对支原体肺炎诊断价值研究[J].安徽医药,2021,25(4):733-736.[8]陈桂民．阿奇霉素序贯疗法治疗小儿支原体肺炎的临床疗效和安全性分析[J].吉林医学,2018,39(3):425-427．[9]唐瑞琪,黄英.糖皮质激素在儿童难治性肺炎支原体肺炎中的应用[J].儿科药学杂志,2016,22(11):56-58．[10]黄欢欢,蔡成思,黄育丹,等.五虎汤合葶苈大枣泻肺汤联合阿奇霉素对小儿支原体肺炎炎症因子与免疫功能的影响[J].中国药物与临床,2018,18(6):144－146.[11]张美丽.氨溴特罗联合阿奇霉素对支原体肺炎患儿临床疗效观察[J].实用中西医结合临床,2018,8(5):34-36.[12]邓玉林,梁樑.小儿肺炎支原体感染临床检验的诊断价值探讨[J].质量安全与检验检测,2021,31(6):87-89,94.[13]朱海涛,刘哲豪.标准治疗联合生大黄灌肠对3种轻症急性胰腺炎的治疗效果[J].贵阳医学院学报,2017,42(11):1311-1314.[14]吴云锋,谯敏.布地奈德联合复方异丙托溴铵治疗小儿肺炎支原体感染后咳嗽临床效果观察[J].现代诊断与治疗,2016,27(1):75-77.[15]王江涛.肺力咳合剂联合复方异丙托溴铵治疗婴幼儿急性支气管肺炎的临床研究[J].现代药物与临床,2018,33(4):823-827[16]黄芳,唐林芬,司马燕.布地奈德联合复方异丙托溴铵雾化吸入治疗儿童支气管肺炎的疗效观察[J].实用临床医药杂志,2017,21(11):180-181,183.[17]舒菊娟,张炫化.清热化痰法联合阿奇霉素治疗小儿肺炎支原体感染的支气管炎临床疗效研究[J].世界中西医结合杂志,2017,12(2):226-229.[18]张根民.肺力咳合剂与氨溴特罗口服液对小儿急性支气管炎的效果对照研究[J].中医临床研究,2018,10(32):24-26.[19]王莲,赵腾飞.肺炎支原体感染引起毛细支气管炎与儿童哮喘相关因素分析[J].国际医药卫生导报,2018,24(7):991-994.

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更新日期/Last Update: 1900-01-01