[1]刘俊秀.血清和肽素水平测定在心力衰竭患者诊断和预后评价中的价值[J].医学信息,2021,34(15):190-192.[doi:10.3969/j.issn.1006-1959.2021.15.054]
　LIU Jun-xiu.The Value of Serum and Copeptin Levels in the Diagnosis and Prognostic Evaluation of Patients with Heart Failure[J].Medical Information,2021,34(15):190-192.[doi:10.3969/j.issn.1006-1959.2021.15.054]
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血清和肽素水平测定在心力衰竭患者诊断和预后评价中的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年15期
页码:
190-192
栏目:
诊疗技术
出版日期:
2021-08-01

文章信息/Info

Title:
The Value of Serum and Copeptin Levels in the Diagnosis and Prognostic Evaluation of Patients with Heart Failure
文章编号:
1006-1959（2021）15-0190-03
作者:
刘俊秀
（天津市武清区人民医院健康体检科，天津 301700）
Author(s):
LIU Jun-xiu
(Department of Health Examination,Wuqing People’s Hospital,Tianjin 301700,China)
关键词:
心力衰竭; 血清和肽素; 血浆脑钠肽
Keywords:
Heart failure; Serum and copeptin; Plasma brain natriuretic peptide
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2021.15.054
文献标志码:
A
摘要:
目的 探讨血清和肽素水平测定在心力衰竭患者诊断和预后中的价值。方法 选取2018年7月~2020年7月我院诊治的190例心力衰竭患者设为观察组，另选取同期我院体检健康者190名作为对照组，比较两组血清CPT、BNP水平及不同心功能分级和不同预后心力衰竭患者CPT和BNP水平，并分析不同指标诊断心力衰竭的诊断效能及CPT与心功能分级的相关性。结果 观察组CPT、BNP水平均高于对照组，差异有统计学意义（P＜0.05）；心功能Ⅳ级心力衰竭者CPT、BNP均高于心功能Ⅱ级、Ⅲ级心力衰竭者，且Ⅲ级高于Ⅱ级，差异有统计学意义（P＜0.05）；治疗有效者CPT、BNP水平均低于无效者，差异有统计学意义（P＜0.05）；CPT诊断心力衰竭敏感度高于BNP、CPT联合BNP，特异度低于BNP、CPT联合BNP（P＜0.05）；CPT与心功能分级呈正相关（P＜0.05）。结论 血清和肽素水平测定可较好的预测心力衰竭患者病情严重程度，并且心功能分级与血清和肽素密切相关，可作为心力衰竭患者的早期诊断、预后评估的指标。
Abstract:
Objective To explore the value of serum and copeptin levels in the diagnosis and prognosis of patients with heart failure.Methods 190 patients with heart failure diagnosed and treated in our hospital from July 2018 to July 2020 were selected as the observation group.In addition, 190 healthy people in our hospital during the physical examination were selected as the control group to compare the serum CPT and BNP levels and the CPT and BNP levels of patients with heart failure with different cardiac function grades and different prognosis and analyze the diagnostic efficacy of different indicators in the diagnosis of heart failure and the correlation between CPT and cardiac function classification.Results The CPT and BNP levels of the observation group were higher than those of the control group,the difference was statistically significant (P＜0.05);CPT and BNP in patients with heart function grade Ⅳ heart failure were higher than those with heart function grade Ⅱ and grade Ⅲ heart failure, and grade Ⅲ was higher than grade Ⅱ, the difference was statistically significant (P<0.05);The CPT and BNP levels of the effective treatment were lower than those of the ineffective, the difference was statistically significant (P<0.05);The sensitivity of CPT to diagnose heart failure was higher than that of BNP, CPT combined with BNP, and the specificity was lower than that of BNP, CPT combined with BNP (P<0.05);CPT was positively correlated with cardiac function classification (P＜0.05).Conclusion The determination of serum and copeptin levels can better predict the severity of heart failure in patients with heart failure, and the classification of heart function is closely related to serum and copeptin, and can be used as an indicator for early diagnosis and prognostic evaluation of heart failure patients.

参考文献/References:

[1]马秋恩.环磷腺苷葡胺联合依那普利对慢性心衰患者BNP、RDW水平的影响[J].心血管康复医学杂志,2017,26(3):288-291. [2]可海霞,张金盈,刘瑾春,等.托拉塞米对重度顽固性心力衰竭患者BNP及胱抑素C的影响[J].重庆医学,2015,44(22):3134-3136. [3]周琦,孙刚.心舒宁合剂对舒张性心力衰竭患者BNP、CA125和CRP的影响分析[J].中国现代医学杂志,2017,27(19):116-119. [4]王喆.《中国心力衰竭诊断和治疗指南2014》解读[J].中国临床医生杂志,2016,44(5):14-16. [5]陈薇,胡汉宁,黎安玲,等.慢性心力衰竭患者血浆NGAL、GAL水平变化及与NT－proBNP相关性的研究[J].临床心血管病杂志,2015,31(8):864-867. [6]胡见英.血浆BNP、PDW与RDW联合测定诊断慢性心力衰竭的价值[J].医学信息,2021,34(2):174-176. [7]简立国,樊清波,丁同斌,等.慢性心力衰竭患者基质金属蛋白酶与Ｂ型脑钠肽的相关性[J].中华老年医学杂志,2017,36(7):739-741. [8]邹筱冬,崔进,何芸.慢性心力衰竭患者血清脑钠肽、瘦素和脂联素水平变化及意义[J].山东医药,2016,56(17):59-61. [9]吕远军，刘健培.血清和肽素对急性胰腺炎的诊断和预后判断作用[J].实用医学杂志,2015,31(16):2658-2660. [10]王星.血清和肽素,脂联素水平检测在慢性心力衰竭患者心功能分级中的应用价值[J].社区医学杂志,2018,3(16):73-74. [11]苏明,徐庆东,姜松青,等.终末期肾脏病患者和肽素水平及临床价值探讨[J].四川医学,2017(8):961-964. [12]Wasilewski MA,Myers VD,Recchia FA,et al.Arginine vasopressin receptor signaling and functional outcomes in heart failure[J].Cell Signal,2016,28(3):224-233. [13]赵玉清,袁桂莉,张进顺,等.和肽素联合N末端B型利钠肽原评估慢性心力衰竭患者预后的价值[J].中国循环杂志,2015,29(4):275-278. [14]傅永平,周玥.和肽素和NT－proBNP联合检测在慢性心力衰竭患者病情分级中的应用[J].中华急诊医学杂志,2016,25(4):509-511. [15]余俊,朱武军,杜燕,等.慢性心力衰竭患者血清和肽素、心钠素、脑钠肽水平变化及其临床意义[J].第三军医大学学报,2015,36(3):296-297. [16]蒋静,姚祥.血清BNP、PCT、TNF-α和CRP水平与AECOPD合并心力衰竭患者心功能的关系[J].河南医学研究,2018,27(17):3112-3113. [17]申岩,高瑞敏,康玲玲,等.不同程度CHF患者血浆BNP,和肽素水平变化及其与心功能分级的相关性[J].心血管康复医学杂志,2019,28(5):29-32. [18]曾磊,刘志红.老年慢性心力衰竭患者NT-proBNP,UA水平与心功能分级,预后的相关性分析[J].医学临床研究,2019,36(4):693-695.

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更新日期/Last Update: 1900-01-01